2-Iod-1-phenylpropanol | 1190884-30-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Iod-1-phenylpropanol
• 英文别名: 2-Iod-1-phenylpropan-1-ol；2-iodo-1-phenyl-propan-1-ol；β-Jod-α-oxy-α-phenyl-propan；2-Jod-1-phenyl-propan-1-ol；1²-Jod-1¹-oxy-1-propyl-benzol；2-Iodo-1-phenylpropan-1-ol
• CAS: 1190884-30-0
• 化学式: C₉H₁₁IO
• 分子量: 262.09
• InChiKey: DDIRVGKIQBDTGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Iod-1-phenylpropanol 在 sodium bromate 、 硫酸 、 sodium bromide 作用下， 以 甲醇 、 1,2-二氯乙烷 为溶剂， 反应 3.0h， 生成 2-苯基丙醛
  参考文献：
  名称：

  Halonium Ion-Assisted Deiodination of Styrene-Based Vicinal Iodohydrins Followed by Rearrangement through Phenyl Migration

  摘要：

  Acid activation of bromate/bromide couple at 0-10 degrees C was found to trigger the deiodination of styrene-based vicinal iodohydrins. Violet coloration of the organic layer was ascribed to formation of IBr. Deiodination was followed by phenyl migration and deprotonation leading to formation of phenyl acetone and 2-phenylpropanal in good yields from 1-iodo-2-phenylpropan-2-ol and 2-iodo-1-phenylpropan-1-ol, respectively. Phenyl acetaldehyde-which was obtained in 92% GC yield from styrene iodohydrin-was also presumably formed in analogous manner. NBS and HOCl too were effective for transformation of styrene iodohydrin into phenyl acetaldehyde,

  DOI：

  10.1021/jo9013707
• 作为产物：
  描述：

  甲基苯乙烯 在 碘 作用下， 以 环丁砜 、 氯仿 为溶剂， 生成 2-Iod-1-phenylpropanol
  参考文献：
  名称：

  Cambie,R.C. et al., Journal of the Chemical Society. Perkin transactions I, 1977, p. 226 - 230

  摘要：

  DOI：

文献信息

• Cambie,R.C. et al., Journal of the Chemical Society. Perkin transactions I, 1976, p. 1961 - 1966
  作者：Cambie,R.C. et al.

  DOI：——

  日期：——
• Involvement of neighboring chlorine in the exchange reactions of iodine monochloride and vicinal organic iodochlorides
  作者：George H. Schmid、James W. Gordon

  DOI：10.1021/jo00170a026

  日期：1983.11
• Development of Antigen Detection ELISA for the Diagnosis of Brugian and Bancroftian Filariasis Using Antibodies to Recombinant Filarial Antigens Bm-SXP-1 and Wb-SXP-1
  作者：Pattabhiraman Lalitha、Devarajan Eswaran、Muniratnam Gnanasekar、Kakuturu Venkata Nagaraja Rao、Rangarajan Badri Narayanan、Alan Scott、Thomas Nutman、Perumal Kaliraj

  DOI：10.1111/j.1348-0421.2002.tb02703.x

  日期：2002.5

  AbstractAntibodies specific to recombinant filarial antigens Wb‐SXP‐1 and Bm‐SXP‐1 have been used to develop a sandwich ELISA for the detection of circulating filarial antigen (CFA) in sera from patients with lymphatic filariasis caused by Wuchereria bancrofti of Brugia malayi. In patients with W. bancrofti infections, a high proportion of microfilaria (mf) positive (MF) and low proportions of patients with chronic pathology (CP) and endemic normals (EN) showed the presence of CFA. Similarly in patients with brugian infections a high proportion of mf positive individuals contained CFA while none of the patients with chronic pathology or endemic normals showed the presence of CFA. Sera from patients with other parasitic infections (OPI) like O. volvulus, Loa loa, Ascaris lumbricoides and from individuals residing in areas non‐endemic to filariasis did not exhibit any reactivity. This assay shows promise for the detection of microfilaremic infections in lymphatic filariasis and its usefulness as a diagnostic tool especially in B. malayi infections, needs to be further evaluated.
• A Novel Mechanism of Fluconazole Resistance Associated with Fluconazole Sequestration in<i>Candida albicans</i>Isolates from a Myelofibrosis Patient
  作者：Kazunori Maebashi、Michinari Kudoh、Yayoi Nishiyama、Koichi Makimura、Katsuhisa Uchida、Takeshi Mori、Hideyo Yamaguchi

  DOI：10.1111/j.1348-0421.2002.tb02702.x

  日期：2002.5

  AbstractA series of 10 strains of Candida albicans, from TIMM 3309 to TIMM 3318, were repeatedly isolated in one myelofibrosis‐complicated patient with recurrent candidemia. The latter five isolates, from TIMM 3314 to TIMM 3318, became suddenly resistant to fluconazole during the 10 to 16 weeks after antimycotic therapy. We investigated the resistant mechanism of fluconazole using one susceptible isolate and two of the five resistant isolates in the series. The ergosterol synthesis by cell‐free extracts from the two resistant isolates was less susceptible to fluconazole partly as a result of a decreased affinity of cytochrome P‐450. Unexpectedly, these two resistant isolates showed higher levels of an intracellular accumulation of [3H]fluconazole than the susceptible isolate and the control strain of C. albicans ATCC 10231. In the resistant isolate, TIMM 3318, most intracellular incorporated fluconazole was distributed in the 12,000 × g pellet (P‐120) fraction by centrifugation unlike the two susceptible strains. An observation of the ultrastructure of TIMM 3318 showed the most notable alteration to be the characteristic appearance of numerous vesicular vacuoles (diameter, 150 to 400 nm); these vacuoles were not observed, however, in either of the susceptible strains. A direct observation of the subcellular fraction prepared from TIMM 3318 by the electron microscopy negative‐staining method suggests that most of the vesicular vacuoles were recovered in the P‐120 fraction. These results suggest that fluconazole sequestration caused by vesicular vacuoles of the resistant isolate might act as a novel mechanism of fluconazole resistance besides the decreased affinity of cytochrome P‐450.
• Fourneau; Tiffeneau, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1905, vol. 140, p. 1597
  作者：Fourneau、Tiffeneau

  DOI：——

  日期：——