4-(2'-Hydroxyethoxy)-2,11-endo-dimethyl-2,4-ethanoadamantane | 132156-59-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2'-Hydroxyethoxy)-2,11-endo-dimethyl-2,4-ethanoadamantane
• CAS: 132156-59-3
• 化学式: C₁₆H₂₆O₂
• 分子量: 250.381
• InChiKey: RWOHMVVMXMBTQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.85
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  2^e-tert-Butyl-2^a-hydroxyadamantane-4-one-4-(ethyleneacetal) 在 三乙基硅烷 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以37%的产率得到2,11,11-trimethyl-15-oxa-2,4-ethanoadamantane
  参考文献：
  名称：

  Reactions of substituted 2-tert-butyladamantan-2-ols

  摘要：

  The reaction of substituted 2-tert-butyladamantan-2-ols with triethylsilane and/or hydriodic acid is described. In addition to the expected hydrocarbons, interesting rearrangement products were observed in many cases. Reaction mechanisms are presented to rationalize the experimental results.

  DOI：

  10.1021/jo00005a012

文献信息

• Reactions of substituted 2-tert-butyladamantan-2-ols
  作者：Helmut Duddeck、Doris Rosenbaum

  DOI：10.1021/jo00005a012

  日期：1991.3

  The reaction of substituted 2-tert-butyladamantan-2-ols with triethylsilane and/or hydriodic acid is described. In addition to the expected hydrocarbons, interesting rearrangement products were observed in many cases. Reaction mechanisms are presented to rationalize the experimental results.