methyl 4-{4-[(tert-butyldimethylsilyl)oxy]-3-methoxyphenyl}butanoate | 1266674-91-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: methyl 4-{4-[(tert-butyldimethylsilyl)oxy]-3-methoxyphenyl}butanoate
• 英文别名: Methyl 4-[4-[tert-butyl(dimethyl)silyl]oxy-3-methoxyphenyl]butanoate；methyl 4-[4-[tert-butyl(dimethyl)silyl]oxy-3-methoxyphenyl]butanoate
• CAS: 1266674-91-2
• 化学式: C₁₈H₃₀O₄Si
• 分子量: 338.519
• InChiKey: WLGIPSFPEFKIJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.57
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丁香酚 在 咪唑 、 1,10-菲罗啉 、 potassium tert-butylate 、 copper (I) acetate 作用下， 以 甲醇 、 乙醚 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 100.0 ℃ 、101.33 kPa 条件下， 反应 16.0h， 生成 methyl 4-{4-[(tert-butyldimethylsilyl)oxy]-3-methoxyphenyl}butanoate
  参考文献：
  名称：

  Copper-Catalyzed Carboxylation of Alkylboranes with Carbon Dioxide: Formal Reductive Carboxylation of Terminal Alkenes

  摘要：

  Carboxylation of alkylboron compounds (alkyl-9-BBN) with CO2 proceeded in the presence of catalytic amounts of CuOAc/1,10-phenanthroline and a stoichiometric amount of (KOBu)-Bu-t. The alkylboranes are easily and widely available through the alkene hydroboration, and thus the overall process represents a reductive carboxylation of alkenes with CO2. The broad functional group compatibility and the inexpensiveness of the Cu/1,10-phenathoroline catalyst system are attractive features of this protocol.

  DOI：

  10.1021/ol103128x

文献信息

• Copper-Catalyzed Carboxylation of Alkylboranes with Carbon Dioxide: Formal Reductive Carboxylation of Terminal Alkenes
  作者：Hirohisa Ohmiya、Masahito Tanabe、Masaya Sawamura

  DOI：10.1021/ol103128x

  日期：2011.3.4

  Carboxylation of alkylboron compounds (alkyl-9-BBN) with CO2 proceeded in the presence of catalytic amounts of CuOAc/1,10-phenanthroline and a stoichiometric amount of (KOBu)-Bu-t. The alkylboranes are easily and widely available through the alkene hydroboration, and thus the overall process represents a reductive carboxylation of alkenes with CO2. The broad functional group compatibility and the inexpensiveness of the Cu/1,10-phenathoroline catalyst system are attractive features of this protocol.