Butofilolol maleate | 88606-96-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Butofilolol maleate
• 英文别名: (Z)-but-2-enedioic acid;1-[2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-fluorophenyl]butan-1-one
• CAS: 88606-96-6
• 化学式: C21H30FNO7
• 分子量: 427.5
• InChiKey: XAFHIGHFTQNWCF-BTJKTKAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.65
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  133
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• EPOXY-STEROIDAL ALDOSTERONE ANTAGONIST AND BETA-ADRENERGIC ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF CONGESTIVE HEART FAILURE
  申请人：Pharmacia Corporation

  公开号：EP1303306B1

  公开（公告）日：2006-06-21
• Epoxy-steroidal aldosterone antagonist and beta-adrenergic antagonist combination therapy for treatment of congestive heart failure
  申请人：Alexander C. John

  公开号：US20050215537A1

  公开（公告）日：2005-09-29

  A combination therapy comprising a therapeutically-effective amount of an epoxy-steroidal aldosterone receptor antagonist and a therapeutically-effective amount of a beta-adrenergic antagonist is described for treatment of circulatory disorders, including cardiovascular disorders such as hypertension, congestive heart failure, cirrhosis and ascites. Preferred beta-adrenergic antagonists are those compounds having high potency and bioavailability. Preferred epoxy-steroidal aldosterone receptor antagonists are 20-spiroxane steroidal compounds characterized by the presence of a 9α,11α-substituted epoxy moiety. A preferred combination therapy includes the beta-adrenergic antagonist metoprolol ((±)1-(isopropylamino)-3-[p-(2-methoxyethyl)phenoxyl]-2-propanolol succinate) and the aldosterone receptor antagonist epoxymexrenone.
• [EN] PHARMACEUTICAL PRODUCT COMPRISING A SALICYLATE OF AN ESTERIFIABLE BETA-BLOCKER<br/>[FR] PRODUIT PHARMACEUTIQUE COMPORTANT UN SALICYLATE D'UN AGENT BETA-BLOQUANT ESTERIFIABLE
  申请人：CAL INTERNATIONAL LIMITED

  公开号：WO1995020568A1

  公开（公告）日：1995-08-03

  (EN) Salicylates of esterifiable $g(b)-blockers, especially Atenolol-O-Aspirinate, Metoprolol-O-Aspirinate, Pindolol-O-Aspirinate and processes for their preparation are described.(FR) Salicylates d'agents bêta-bloquants estérifiables, notamment l'Aténolol-O-aspirinate, le Métoprolol-O-aspirinate et le Pindolol-O-aspirinate, et leurs procédés de préparation.