N-[N-[3-(4-hydroxy-3-methoxyphenyl) propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester | 329326-75-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[N-[3-(4-hydroxy-3-methoxyphenyl) propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester
• 英文别名: (S)-3-(3-(4-hydroxy-3-methoxyphenyl)propylamino)-4-((S)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino)-4-oxobutanoic acid；(3S)-3-[3-(4-hydroxy-3-methoxyphenyl)propylamino]-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
• CAS: 329326-75-2
• 化学式: C₂₄H₃₀N₂O₇
• 分子量: 458.511
• InChiKey: YCONIUDAZOIBGP-OALUTQOASA-N

物化性质

• 沸点：
  705.2±60.0 °C(Predicted)
• 密度：
  1.247±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  33
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-羟基-3-甲氧基肉桂醛 、 阿斯巴甜 在 钯 sodium hydroxide 、 溶剂黄146 作用下， 以 甲醇 、 水 为溶剂， 生成 N-[N-[3-(4-hydroxy-3-methoxyphenyl) propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester
  参考文献：
  名称：

  PROCESS FOR PRODUCING ASPARTYL DIPEPTIDE ESTER DERIVATIVES

  摘要：

  提供了一种便捷地在工业规模上高产率地生产N-[N-[3-(苯环上具有各种取代基团的苯基)丙基]-L-α-天冬氨酰]-L-苯丙氨酸1-甲酯衍生物的方法，该方法预计将作为一种甜味剂，通过在催化剂和碱的存在下，用3-(苯环上具有指定取代基团的)丙烯醛对天冬氨酸甲酰胺进行还原烷基化反应。

  公开号：

  EP1283213A1

文献信息

• High-Potency Sweetener Composition With Phytoestrogen and Compositions Sweetened Therewith
  申请人：Prakash Indra

  公开号：US20080107776A1

  公开（公告）日：2008-05-08

  The present invention relates generally to functional sweetener compositions comprising non-caloric or low-caloric natural and/or synthetic, high-potency sweeteners and methods for making and using them. In particular, the present invention relates to different functional sweetener compositions comprising at least one non-caloric or low-caloric natural and/or synthetic, high-potency sweetener, at least one sweet taste improving composition, and at least one functional ingredient, such as phytoestrogens. The present invention also relates to functional sweetener compositions and methods that can improve the tastes of non-caloric or low-caloric high-potency sweeteners by imparting a more sugar-like taste or characteristic. In particular, the functional sweetener compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and/or a more sugar-like flavor profile.

  本发明涉及一般性的功能性甜味剂组合物，包括非卡路里或低卡路里的天然和/或合成高效甜味剂，以及制备和使用它们的方法。特别地，本发明涉及不同的功能性甜味剂组合物，包括至少一个非卡路里或低卡路里的天然和/或合成高效甜味剂、至少一个甜味改善组合物和至少一个功能性成分，例如植物雌激素。本发明还涉及功能性甜味剂组合物和方法，可以通过赋予更类似于糖的味道或特性来改善非卡路里或低卡路里高效甜味剂的口感。特别地，功能性甜味剂组合物和方法提供更类似于糖的时间特征，包括甜味的开始和持续时间，以及/或更类似于糖的风味特征。
• TISSUE DEGENERATION PROTECTION
  申请人：Geuns Joannes

  公开号：US20100099640A1

  公开（公告）日：2010-04-22

  The present invention provides isolated or essentially pure diterpenoic tetrahydropyran, such as steviol-19-glucuronide, steviol, stevioside and rebaudioside processes for obtaining the same and methods for obtaining stable pharmaceutically acceptable salts of the same for use of such compounds or compositions in a treatment of cardiovascular disorders or vascular disease or for the manufacture of medicaments to treat a condition of a cardiovascular disorder or vascular disease.

  本发明提供了分离或基本纯的二萜四氢吡喃类化合物，例如甜菊糖苷-19-葡萄糖醛酸酯，甜菊糖，甜菊糖苷和葛根糖苷，以及获得它们的方法和获得这些化合物的稳定的药学上可接受的盐的方法，用于治疗心血管疾病或血管疾病或用于制造治疗心血管疾病或血管疾病症状的药物。
• Process for producing aspartame derivatives, process for purifying aspartame derivatives, production intermediates, and process for producing production intermediates
  申请人：AJINOMOTO CO., INC.

  公开号：US20020127320A1

  公开（公告）日：2002-09-12

  N-[N-[3-(2-hydroxy-substituted phenyl)propyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester derivatives, which are useful as sweeteners, may be conveniently produced by subjecting a 2-hydroxychroman derivative having various substituents on the benzene ring and aspartame to a reductive alkylation reaction. These compounds may be purified by subjecting such a derivative containing one or more impurities to a crystallization step to crystallize the same. Further, there are provided a process for producing dialkoxychroman derivatives useful as intermediates for the production of such aspartame derivatives in the above process, and novel dialkoxychroman derivatives thus produced, which are excellent as the production intermediate.

  这段文字的含义是： N-[N-3-(2-羟基取代苯基)丙基]-L-α-天冬氨酸-L-苯丙氨酸1-甲基酯衍生物可用作甜味剂，可通过将具有苯环上不同取代基的2-羟基色酮衍生物和阿斯巴甜进行还原烷基化反应来方便地制备。这些化合物可以通过将含有一种或多种杂质的衍生物经过结晶步骤结晶来纯化。此外，还提供了一种用于生产上述过程中的阿斯巴甜衍生物的中间体的二烷氧基色酮衍生物的生产过程，以及由此产生的新型二烷氧基色酮衍生物，其作为生产中间体非常优秀。
• High-Potency Sweetener Composition with Glucosamine and Compositions Sweetened Therewith
  申请人：Prakash Indra

  公开号：US20070116827A1

  公开（公告）日：2007-05-24

  The present invention relates generally to functional sweetener compositions comprising non-caloric or low-caloric natural and/or synthetic high-potency sweeteners and methods for making and using them. In particular, the present invention relates to different functional sweetener compositions comprising at least one non-caloric or low-caloric natural and/or synthetic high potency sweetener, at least one sweet taste improving composition, and at least one functional ingredient, such as glucosamine. The present invention also relates to functional sweetener compositions and methods that can improve the tastes of non-caloric or low-caloric high-potency sweeteners by imparting a more sugar-like taste or characteristic. In particular, the functional sweetener compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and/or a more sugar-like flavor profile.

  本发明涉及一般性的功能性甜味剂组合物，包括无热量或低热量的天然和/或合成高强度甜味剂以及制备和使用它们的方法。特别地，本发明涉及不同的功能性甜味剂组合物，包括至少一种无热量或低热量的天然和/或合成高强度甜味剂，至少一种增甜剂组合物和至少一种功能性成分，如葡萄糖胺。本发明还涉及功能性甜味剂组合物和方法，可以通过赋予更像糖的味道或特性来改善无热量或低热量高强度甜味剂的味道。特别地，功能性甜味剂组合物和方法提供更像糖的时间特性，包括甜味的开始和持续时间，和/或更像糖的口味特性。
• High-Potency Sweetener Composition with Mineral and Compositions Sweetened Therewith
  申请人：Prakash Indra

  公开号：US20070116832A1

  公开（公告）日：2007-05-24

  The present invention relates generally to functional sweetener compositions comprising non-caloric or low-caloric natural and/or synthetic high-potency sweeteners and methods for making and using them. In particular, the present invention relates to different functional sweetener compositions comprising at least one non-caloric or low-caloric natural and/or synthetic high-potency sweetener, at least one sweet taste improving composition, and at least one functional ingredient, such as a mineral. The present invention also relates to functional sweetener compositions and methods that can improve the tastes of non-caloric or low-caloric high-potency sweeteners by imparting a more sugar-like taste or characteristic. In particular, the functional sweetener compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and/or a more sugar-like favor profile.

  本发明涉及一般性的功能性甜味剂组合物，包括非热量或低热量的天然和/或合成高效甜味剂，以及制备和使用它们的方法。具体而言，本发明涉及不同的功能性甜味剂组合物，包括至少一种非热量或低热量的天然和/或合成高效甜味剂，至少一种甜味改善组合物和至少一种功能性成分，例如矿物质。本发明还涉及功能性甜味剂组合物和方法，可以通过赋予更像糖的味道或特征来改善非热量或低热量高效甜味剂的口感。具体而言，功能性甜味剂组合物和方法提供更像糖的时间特征，包括甜味的开始和持续时间，和/或更像糖的口感特征。