4-anilino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one | 60473-50-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-anilino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
• 英文别名: 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-2-phenyl-4-(phenylamino)-；4-anilino-1,5-dimethyl-2-phenylpyrazol-3-one
• CAS: 60473-50-9
• 化学式: C₁₇H₁₇N₃O
• 分子量: 279.341
• InChiKey: IBZAPCYRYUEHCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-anilino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one 在 sodium hydroxide 作用下， 以 xylene 为溶剂， 反应 5.0h， 以42%的产率得到5-anilino-6-methyl-3-phenyl-4(3H)-pyrimidone
  参考文献：
  名称：

  Udea, Taisei; Oda, Noriichi; Ito, Isoo, Chemical and pharmaceutical bulletin, 1980, vol. 28, # 7, p. 2144 - 2147

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(N-Acetyl-N-phenyl)amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on 以89%的产率得到
  参考文献：
  名称：

  UEDA TAISEI; ODA NORIICHI; ITO ISOO, YAKUGAKU DZASSI, YAKUGAKU ZASSNI, J. PHARM. SOS. JAR. , 1976, 96+

  摘要：

  DOI：

文献信息

• L-glutamic acid oxidase, its production, and its use
  申请人：Yamasa Shoyu Kabushiki Kaisha

  公开号：EP0097949A2

  公开（公告）日：1984-01-11

  The present invention consists of the L-glutamic acid oxidase which is an L-amino acid oxidase catalyzing the oxidative deamination of the a-amino group of L-glutamic acid in the presence of water and oxygen to form a-ketoglutaric acid, ammonia and hydrogen peroxide, and having a very high substrate specificity for L-glutamic acid substantially without acting on L-glutamine and L-histidine and also a high stability, a microbiological method of production thereof, an analytical method for assay of L-glutamic acid in a sample to be analyzed by the use of this enzyme, a reagent for analysis to practice the analytical method, a kit for analysis comprising said reagent, and a biosensor employing said enzyme.

  本发明包括L-谷氨酸氧化酶，它是一种L-氨基酸氧化酶，在水和氧的存在下催化L-谷氨酸的a-氨基氧化脱氨，生成a-酮戊二酸、氨和过氧化氢，对L-谷氨酸具有很高的底物特异性，基本上不作用于L-谷氨酰胺和L-组氨酸，而且具有很高的稳定性、一种生产该酶的微生物学方法、一种利用该酶分析样品中 L-谷氨酸的分析方法、一种用于实施该分析方法的分析试剂、一种包含上述试剂的分析试剂盒以及一种利用上述酶的生物传感器。
• Ligand-free CuTC-catalyzed <i>N</i> -arylation of amides, anilines and 4-aminoantipyrine: synthesis of <i>N</i> -arylacrylamides, 4-amido-<i>N</i> -phenylbenzamides and 4-amino(<i>N</i> -phenyl)antipyrenes
  作者：Zheng-Jun Quan、Hai-Dong Xia、Zhang Zhang、Yu-Xia Da、Xi-Cun Wang

  DOI：10.1002/aoc.3080

  日期：2014.2

  N‐Arylation of amides and anilines with aryl iodides was efficiently catalyzed by copper thiophenecarboxylate under ligand‐free conditions with good to excellent yields. A variety of substituted aryl iodides, amides, anilines and 4‐aminoantipyrine were found to be applicable to the simple catalytic system. Furthermore, some practical, unique secondary amides, such as N‐arylacrylamides and 4‐amido‐N‐phenylbenzamides, and 4‐amino(N‐phenyl)antipyrenes, which are difficult to obtain by the classical methods, were prepared. Copyright © 2013 John Wiley & Sons, Ltd.
• Ueda, Taisei; Nagai, Shin-Ichi; Oda, Noriichi, Chemical and pharmaceutical bulletin, 1984, vol. 32, # 4, p. 1604 - 1607
  作者：Ueda, Taisei、Nagai, Shin-Ichi、Oda, Noriichi、Sakakibara, Jinsaku

  DOI：——

  日期：——
• UEDA TAISEI; ODA NORIICHI; ITO ISOO, CHEM. AND PHARM. BULL., 1980, 28, NO 7, 2144-2147
  作者：UEDA TAISEI、 ODA NORIICHI、 ITO ISOO

  DOI：——

  日期：——
• UEDA, TAISEI;NAGAI, SHIN-ICHI;ODA, NORIICHI;SAKAKIBARA, JINSAKU, CHEM. AND PHARM. BULL., 1984, 32, N 4, 1604-1607
  作者：UEDA, TAISEI、NAGAI, SHIN-ICHI、ODA, NORIICHI、SAKAKIBARA, JINSAKU

  DOI：——

  日期：——