1,5-dimethyl-2-phenyl-4-[2-(piperazin-2ylidene)hydrazinyl]-1,2-dihydropyrazol-3-one | 1240472-07-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,5-dimethyl-2-phenyl-4-[2-(piperazin-2ylidene)hydrazinyl]-1,2-dihydropyrazol-3-one
• 英文别名: 1,5-Dimethyl-2-phenyl-4-[2-(piperazin-2-ylidene)hydrazinyl]-1,2-dihydropyrazol-3-one；1,5-dimethyl-2-phenyl-4-[2-(1,2,3,6-tetrahydropyrazin-5-yl)hydrazinyl]pyrazol-3-one
• CAS: 1240472-07-4
• 化学式: C₁₅H₂₀N₆O
• 分子量: 300.363
• InChiKey: JGWLFUBABRIAJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  哌嗪 、 4-氨基安替比林 在 盐酸 、 sodium acetate 、 sodium nitrite 作用下， 以 乙醇 、 水 为溶剂， 以65%的产率得到1,5-dimethyl-2-phenyl-4-[2-(piperazin-2ylidene)hydrazinyl]-1,2-dihydropyrazol-3-one
  参考文献：
  名称：

  Synthesis and anti-hbv activity of 4-aminoanti- pyrine derivatives

  摘要：

  The reactions of 4-aminoantipyrine with acetylacetone, ethyl acetoacetate, morpholine, piperazine, and ethyl cyanoacetate were studied. All structures were determined by (1)H NMR and mass spectroscopy techniques.

  DOI：

  10.1007/s10593-010-0472-7

文献信息

• Synthesis and anti-hbv activity of 4-aminoanti- pyrine derivatives
  作者：A. A.-H. Abdel-Rahman、A. H. A. Ahmed、M. M. M. Ramiz

  DOI：10.1007/s10593-010-0472-7

  日期：2010.5

  The reactions of 4-aminoantipyrine with acetylacetone, ethyl acetoacetate, morpholine, piperazine, and ethyl cyanoacetate were studied. All structures were determined by (1)H NMR and mass spectroscopy techniques.