DL-N-benzoylcysteine | 7218-05-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: DL-N-benzoylcysteine
• 英文别名: N-Benzoyl-DL-cystein；N-benzoylcysteine；N-Benzoyl-cystein；2-benzamido-3-sulfanylpropanoic acid
• CAS: 7218-05-5
• 化学式: C₁₀H₁₁NO₃S
• 分子量: 225.268
• InChiKey: LJWSDBHOEIBWJY-UHFFFAOYSA-N

物化性质

• 熔点：
  136-137 °C
• 沸点：
  486.7±40.0 °C(Predicted)
• 密度：
  1.310±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  67.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  DL-N-benzoylcysteine 、 mercury(II) iodide 在 NaOH 作用下， 以 水 为溶剂， 以100%的产率得到Hg(N-benzoylcysteinate)
  参考文献：
  名称：

  Neikovskii, S. I.; Zegzhda, G. D.; Avershina, O. I., Russian Journal of Inorganic Chemistry, 1977, vol. 22, p. 1306 - 1309

  摘要：

  DOI：
• 作为产物：
  描述：

  2-Phenyl-2-thiazolin-4-carbonsaeure-hydrochlorid 以 水 为溶剂， 以98%的产率得到DL-N-benzoylcysteine
  参考文献：
  名称：

  Effenberger, Franz; Beisswenger, Thomas; Dannenhauer, Fritz, Chemische Berichte, 1988, vol. 121, p. 2209 - 2224

  摘要：

  DOI：
• 作为试剂：
  描述：

  3-辛酮 在 锂硼氢 、 DL-N-benzoylcysteine 作用下， 以 四氢呋喃 、 叔丁醇 为溶剂， 生成 (R)-octan-3-ol
  参考文献：
  名称：

  Matsumori, Kunihiko; Izumi, Susumu; Watanabe, Hiroyasu, Agricultural and Biological Chemistry, 1989, vol. 53, # 7, p. 1777 - 1782

  摘要：

  DOI：

文献信息

• <i>S</i>-Aroylthiooximes: A Facile Route to Hydrogen Sulfide Releasing Compounds with Structure-Dependent Release Kinetics
  作者：Jeffrey C. Foster、Chadwick R. Powell、Scott C. Radzinski、John B. Matson

  DOI：10.1021/ol500385a

  日期：2014.3.21

  We report the facile preparation of a family of S-aroylthiooxime (SATO) H2S donors, which are synthesized via a click reaction analogous to oxime formation between S-aroylthiohydroxylamines (SATHAs) and aldehydes or ketones. Analysis of cysteine-triggered H2S release revealed structure-dependent release kinetics with half-lives from 8–82 min by substitution of the SATHA ring. The pseudo-first-order

  我们报告的家庭-S-芳香酰硫肟（SATO）H 2 S供体的简便制备，通过类似于在S-芳香酰硫羟胺（SATHAs）与醛或酮之间肟形成的点击反应合成。半胱氨酸触发的H 2 S释放分析表明，通过取代SATHA环，结构依赖的释放动力学具有8-82分钟的半衰期。取代的SATO的拟一阶速率常数符合标准线性自由能关系（ρ= 1.05），表明对电子效应具有显着的敏感性。
• Compound embodiments that release H2S by reaction with a reactive compound and methods of making and using the same
  申请人：University of Oregon

  公开号：US11078157B1

  公开（公告）日：2021-08-03

  Disclosed herein are embodiments of a donor compound that releases H2S by reacting with a reactive compound. The donor compound embodiments described herein can be used to deliver H2S to a subject or a sample and further can be used to administer therapeutic agents. The donor compound embodiments also can facilitate bioconjugation. Methods of making and using the donor compound embodiments also are disclosed.

  本文揭示了一种供体化合物的实施例，通过与反应性化合物发生反应释放H2S。本文描述的供体化合物实施例可用于向受试者或样品释放H2S，并且进一步可用于给药治疗剂。供体化合物实施例还可以促进生物共轭。还公开了制备和使用供体化合物实施例的方法。
• NOVEL ANTIOXIDANTS AND METHODS OF TREATMENT
  申请人：Weiner Carl P.

  公开号：US20090318454A1

  公开（公告）日：2009-12-24

  Formula 1 is an antioxidant compound, wherein R, R1, or D is an antioxidant substituent; R and D are each independently selected from hydrogen or groups containing cysteine, thiols, disulfides, amino acids, amines, amides, or carboxylic acids; when one of R or D is hydrogen, the other includes a thiol, disulfide, or carboxylic acid; A is CO, SO, SO 2 , or C═S; E is one or more ring groups which are aromatic, carbocyclic, and/or heterocyclic 5, 6 and 7 membered rings being mono, bi, tri, tetra, penta, hexa, hepta or octa cyclic fused rings that are substituted or unsubstituted, each heterocyclic ring can include hetero atoms chosen from to O, S, N, Se, or P; each R1 is at a para, meta, and/or ortho position; n is 1, 2, 3, 4, or 5 for each ring; and each R1 is hydrogen or an antioxidant substituent.

  Formula 1是一种抗氧化化合物，其中R，R1或D是抗氧化剂取代基；R和D分别独立选择自氢或含有半胱氨酸，巯基，二硫键，氨基酸，胺，酰胺或羧酸的基团；当R或D中的一个是氢时，另一个包括巯基，二硫键或羧酸；A是CO，SO，SO2或C═S；E是一个或多个芳香族，碳环或杂环的环基团，其中5, 6和7个成员环可以是单环，双环，三环，四环，五环，六环，七环或八环的融合环，可以是取代或未取代的，每个杂环可以包含从O，S，N，Se或P选择的杂原子；每个R1位于对位，间位和/或邻位；n对于每个环是1, 2, 3, 4或5；每个R1是氢或抗氧化剂取代基。
• Delivery of a substance to a pre-determined site
  申请人：Friesen Heinz Edward Robert

  公开号：US20050272677A1

  公开（公告）日：2005-12-08

  The invention is directed to delivery vehicles for delivering a substance of interest to a predetermined site. The delivery vehicle includes a substance and means for inducing availability of at least one compartment of the delivery vehicle toward the exterior, thus, allowing access of the substance to the exterior of the delivery vehicle at the predetermined site. The invention is further directed to uses of the delivery vehicle and methods for preparing the delivery vehicle.

  本发明涉及用于将所需物质传递至预定地点的传递车辆。该传递车辆包括物质和诱导至少一个传递车辆隔室向外部可用的手段，从而允许在预定地点将物质访问到传递车辆的外部。本发明还涉及传递车辆的用途和制备传递车辆的方法。
• Conjugate having cytotoxicity and process for the preparation thereof
  申请人：TEIJIN LIMITED

  公开号：EP0112720A2

  公开（公告）日：1984-07-04

  A conjugate having cytotoxicity prepared by covalently binding a polymer which has cytotoxic substances linked to its side chains and a reactive group at its terminal to an immunoglobulin, or its fragment, which is capable of selectively binding to a particular antigen possessed by cells to be killed.

  一种具有细胞毒性的共轭物，其制备方法是将一种聚合物与免疫球蛋白或其片段共价结合，免疫球蛋白或其片段的侧链上连接有细胞毒性物质，末端连接有活性基团，而免疫球蛋白或其片段能够选择性地与要杀死的细胞所具有的特定抗原结合。