cystine dimethyl ester | 1069-29-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cystine dimethyl ester
• 英文别名: Cystin-dimethylester；Methyl 2-amino-3-[(2-amino-3-methoxy-3-oxopropyl)disulfanyl]propanoate
• CAS: 1069-29-0
• 化学式: C₈H₁₆N₂O₄S₂
• mdl: MFCD30479362
• 分子量: 268.358
• InChiKey: NXPNPYNCKSWEHA-UHFFFAOYSA-N

物化性质

• 沸点：
  375.5±42.0 °C(Predicted)
• 密度：
  1.318±0.06 g/cm3(Predicted)
• LogP：
  1.610 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  155
• 氢给体数：
  2
• 氢受体数：
  8

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  cystine dimethyl ester 以 二氯甲烷 为溶剂， 反应 19.0h， 生成 (E)-2,2'-Dithio(<1-(methoxycarbonyl)-2,1-ethanediyl>-di-4,5-dihydro-1H-tetrazol-1-yl-5-yliden)bis(cyanessigsaeure-methylester), Bis(triethylammonium)-Salz
  参考文献：
  名称：

  Saalfrank, Rolf W.; Lurz, Claus-Juergen; Hassa, Juergen, Chemische Berichte, 1991, vol. 124, # 3, p. 595 - 608

  摘要：

  DOI：
• 作为产物：
  描述：

  美司坦 生成 cystine dimethyl ester
  参考文献：
  名称：

  SHINKAI, SEIJI;YAMAGUCHI, TOSHIRO;KAWASE, AKITO;KITAMURA, AKIYO;MANADE, O+, J. CHEM. SOC. CHEM. COMMUN.,(1987) N 19, 1506-1508

  摘要：

  DOI：

文献信息

• PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME
  申请人：Mikoshiba Katsuhiko

  公开号：US20120277423A1

  公开（公告）日：2012-11-01

  The present invention relates to: a ketone compound having transglutaminase-inhibiting activity, which is represented by the following Formula 1, 2, or 3: wherein R 1 is a substituted or unsubstituted aryl or heterocyclyl group, R 2 , R 3 , and R 4 are hydrogen atoms, n is 2, X is halogen, R 5 and R 6 independently represent a hydrogen atom or a substituted or unsubstituted C1-C10 alkyl, aryl, or aralkyl group, wherein R 5 and R 6 are not hydrogen atoms at the same time, or R 5 and R 6 may be taken together to form a saturated or unsaturated and substituted or unsubstituted heterocyclyl group containing a nitrogen atom (N); an inhibitor of protein crosslinking comprising the compound; and a composition for preventing or treating a protein-crosslinking causative disease, which comprises the compound or the protein crosslinking inhibitor.

  本发明涉及：一种具有转谷氨酰胺酶抑制活性的酮化合物，由下式1、2或3表示： 其中R1是取代或未取代的芳基或杂环基团，R2、R3和R4是氢原子，n是2，X是卤素，R5和R6独立地表示氢原子或取代或未取代的C1-C10烷基、芳基或芳烷基团，其中R5和R6不同时为氢原子，或者R5和R6可以共同形成含氮原子（N）的饱和或未饱和的、取代或未取代的杂环基团；包含该化合物的蛋白质交联抑制剂；以及包含该化合物或蛋白质交联抑制剂的用于预防或治疗由蛋白质交联引起的疾病的组合物。
• Cycloalkylcarbonylamino Acid Ester Derivative and Process for Producing The Same
  申请人：Kobayashi Nobuo

  公开号：US20090137799A1

  公开（公告）日：2009-05-28

  Cycloalkylcarbonylamino acid ester derivatives, which are raw material intermediates for a novel cycloalkane carboxamide derivative having an action that selectively inhibits cathepsin K, and a production process thereof, are provided. A cycloalkylcarbonylamino acid ester derivative represented by formula (I), or a pharmaceutically acceptable salt thereof: (wherein, R 1 and R 2 represent alkyl groups, alkenyl groups, alkynyl groups, aromatic hydrocarbon groups, heterocyclic groups, etc., R 8 represents an alkyl group having 1 to 6 carbon atoms, and ring A represents a cyclic alkylidene group having 5, 6 or 7 carbon atoms).

  环烷基羰基氨基酸酯衍生物是一种新型环烷烃羧酰胺衍生物的原料中间体，具有选择性抑制卡特普辛K的作用，提供其生产工艺。 表示为式（I）的环烷基羰基氨基酸酯衍生物，或其药学上可接受的盐： （其中，R1和R2代表烷基、烯基、炔基、芳香烃基、杂环基等，R8代表具有1至6个碳原子的烷基，环A代表具有5、6或7个碳原子的环烷基亚基）。
• [EN] COMPOUNDS AS L-CYSTINE CRYSTALLIZATION INHIBITORS AND USES THEREOF<br/>[FR] COMPOSÉS COMME INHIBITEURS DE LA CRISTALLISATION DE LA L-CYSTINE ET UTILISATIONS ASSOCIÉES
  申请人：UNIV NEW YORK

  公开号：WO2011062640A1

  公开（公告）日：2011-05-26

  A method of preventing or inhibiting L-cystine crystallization using the compounds of formula (I) is disclosed, wherein A, L, R1a, R1b, and m are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to L-cystine crystallization, such as comprising (but not limited to) kidney stones.

  揭示了一种使用式(I)化合物预防或抑制L-半胱氨酸结晶的方法，其中A、L、R1a、R1b和m如本文所述。这些化合物可以制备为药物组合物，并可用于预防和治疗与L-半胱氨酸结晶有因果关系的病症，例如包括（但不限于）肾结石。
• 1-[4-(<i>N</i>-Chlorocarbonyl-<i>N</i>-methylamino)phenyl]-2-(phenylsulfonyl)diazene, a Bifunctional Reagent with a Protected Diazonium Function
  作者：Pascal Kessler、Benoît Chatrenet、Maurice Goeldner、Christian Hirth

  DOI：10.1055/s-1990-27095

  日期：——

  1-[4-(N-Chlorocarbonyl-N-methylamino)phenyl]-2-(phenylsulfonyl) diazene is the first bifunctional reagent containing a potential photoactivatable arenediazonium function. The synthesis and the chemical properties of the reagent are described, in particular coupling reactions with series of nucleophiles (primary and secondary amines and a phenolate derivative) and the subsequent deprotection reaction to the corresponding diazonium salt.

  1-[4-(N-氯羧酰基-N-甲基氨基)苯基]-2-(苯磺酰基)偶氮化合物是第一种具有潜在光激活芳基重氮功能的双功能试剂。本文描述了该试剂的合成及其化学性质，特别是与一系列亲核试剂的偶联反应（包括初级和次级胺以及一个酚酸盐衍生物）及随后去保护反应生成相应的重氮盐。
• [EN] FATTY ACID AMIDES WITH A CYSTEAMINE OR AN ACETYLATED CYSTEAMINE GROUP AND USES THEREOF<br/>[FR] AMIDES D'ACIDES GRAS COMPORTANT UN GROUPE CYSTÉAMINE OU UN GROUPE CYSTÉAMINE ACÉTYLÉ ET LEURS UTILISATIONS
  申请人：KRISANI BIOSCIENCE P LTD

  公开号：WO2014045293A1

  公开（公告）日：2014-03-27

  The disclosure herein provides a compound of formula 1, 2 and 3 or its pharmaceutical acceptable salts, as well as polymorphs, solvates, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, transdermal administration, or injection. Such compositions may be used to treatment of metabolic condition, cystinosis, non-alcoholic Steatohepatitis, hypertriglyceridemia or neurodegenerative disorders or its associated complications.

  本公开提供了化合物1、2和3的化学式或其药用可接受的盐，以及其多晶型、溶剂合物和水合物。这些盐可以制备为药物组合物。药物组合物可以制备用于口服、经皮给药或注射。这种组合物可以用于治疗代谢状况、半胱氨酸症、非酒精性脂肪肝、高三酰甘油血症或神经退行性疾病或其相关并发症。