N-Acetyl-neuraminsaeure | 489-46-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-Acetyl-neuraminsaeure
• 英文别名: 5-acetamido-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
• CAS: 489-46-3；6813-81-6；14120-72-0；19342-33-7；21646-00-4；82349-00-6；99395-98-9；99395-99-0；99396-00-6；102734-10-1；140671-47-2；140850-42-6；140850-43-7；140850-44-8；145375-13-9
• 化学式: C₁₁H₁₉NO₉
• 分子量: 309.273
• InChiKey: SQVRNKJHWKZAKO-NTZLIZPOSA-N

物化性质

• 沸点：
  805.0±65.0 °C(Predicted)
• 密度：
  1?+-.0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  177
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• 6'-SIALYLLACTOSE SALTS AND PROCESS FOR THEIR SYNTHESIS AND FOR THE SYNTHESIS OF OTHER ALPHA-SIALYLOLIGOSACCHARIDES
  申请人：Tamerlani Giancarlo

  公开号：US20120071441A1

  公开（公告）日：2012-03-22

  The present invention relates to a process of synthesis of α-sialyl oligosaccharides and in particular of 6′-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.

  本发明涉及一种合成α-唾液酸寡糖的方法，特别是6'-唾液酸乳糖及其盐的合成方法，包括通过Koenigs-Knorr反应耦合的步骤，在条件允许其在工业规模上使用的情况下进行。
• Heterobifunctional pan-selectin inhibitors
  申请人：GlycoMimetics, Inc.

  公开号：EP2264043A1

  公开（公告）日：2010-12-22

  Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).

  本文提供了用于调节由选择素结合介导的体外和体内过程的化合物和方法。更具体地说，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂包括单独的或与称为 BASAs（苄基氨基磺酸）的一类化合物的成员或称为 BACAs（苄基氨基羧酸）的一类化合物的成员相连的特定拟糖体。
• Compositions and products for infectious or inflammatory diseases or conditions
  申请人：Wang Huiru

  公开号：US11246878B2

  公开（公告）日：2022-02-15

  Composition and methods for treating infectious and inflammatory diseases using saccharide based products and therapies. Products can be implemented as a nutritional supplement, a food, a feed, a food additive, a feed additive, a therapeutic product, a rehydration salt, or a rehydration solution. The present disclosure relates generally to the fields of compositions and products containing the compositions, and the use of the compositions or the products for preventing and/or treating infectious or inflammatory diseases or conditions in particular gastrointestinal and respiratory diseases (diarrhea and influenza infections) or inflammatory.

  利用基于糖的产品和疗法治疗感染性和炎症性疾病的组合物和方法。产品可作为营养补充剂、食品、饲料、食品添加剂、饲料添加剂、治疗产品、补液盐或补液溶液使用。本公开一般涉及组合物和含有组合物的产品领域，以及使用组合物或产品预防和/或治疗感染性或炎症性疾病或病症，特别是胃肠道和呼吸道疾病（腹泻和流感感染）或炎症。
• Erythropoietin: remodeling and glycoconjugation of erythropoietin
  申请人：DeFrees Shawn

  公开号：US20070027068A1

  公开（公告）日：2007-02-01

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
  申请人：DeFrees Shawn

  公开号：US20080050772A1

  公开（公告）日：2008-02-28

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.