methionine allyl ester | 128402-71-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methionine allyl ester
• 英文别名: (S)-Methionine allyl ester；NH₂-Met-OAll；prop-2-enyl (2S)-2-amino-4-methylsulfanylbutanoate
• CAS: 128402-71-1
• 化学式: C₈H₁₅NO₂S
• 分子量: 189.279
• InChiKey: LYFIDLJDRXPGEI-ZETCQYMHSA-N

物化性质

• 沸点：
  285.3±35.0 °C(Predicted)
• 密度：
  1.068±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  77.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methionine allyl ester 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  拟肽蛋白法尼基转移酶抑制剂的体外和体内抗疟活性具有改善的膜通透性。

  摘要：

  合成了一系列FTI-2148蛋白法呢基转移酶抑制剂酯前药，以评估酯结构修饰对抗疟活性的影响，并进一步开发具有体内活性的法呢基转移酶抑制剂。对红细胞中恶性疟原虫的评估表明，所有研究的酯均表现出显着的抗疟活性，苄基酯16表现出最佳的抑制作用（ED50 = 150 nM）。此外，化合物16在小鼠体内表现出体内活性，并在50 mg kg（-1）day（-1）剂量下对伯氏疟原虫的寄生虫血症抑制了46.1％。与游离酸相比，酯的增强的抑制能力与改善的细胞膜通透性相一致。

  DOI：

  10.1016/j.bmc.2004.09.020
• 作为产物：
  描述：

  Boc-Met-OAllyl 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 methionine allyl ester
  参考文献：
  名称：

  具有三个不同配位臂的立体三脚架配体：合成和锌（II），铜（I）络合研究

  摘要：

  设计并合成了一个包含手性中心和三个不同配位臂的四齿三脚架配体。与Zn II和Cu I的络合特性通过NMR和光谱学研究。NMR实验表明形成了两个非对映异构体，表明通过金属配位稳定了中央叔胺构型。发现配体的中央叔胺的锥体反应的反转高度依赖于金属离子，溶剂和温度。动态NMR测量用于估计氮原子转化所需的活化能。最后，吸收和圆二色性测量结果证实了对配体的金属络合物会产生圆二色性的期望，但与先前描述的含有两个具有强发色团的相同臂的配体相反，这种光谱的特征不是激子耦合。手性2011。©2010 Wiley-Liss，Inc.。

  DOI：

  10.1002/chir.20833

文献信息

• POLYMER COATINGS ON MEDICAL DEVICES
  申请人：Pickett Christopher John

  公开号：US20100312331A1

  公开（公告）日：2010-12-09

  A medical device, for example a stent, has a surface which in use contacts body tissue, wherein said surface has on it a biocompatible coating layer comprising a polymer having covalently bound allyl-terminated pendent groups, said pendent groups comprising a moiety selected from -0-CH 2 —CH═CH 2 —S—CH 2 —CH═CH 2 —S(=0)-CH 2 —CH═CH 2 —Se—CH 2 —CH═CH 2 and —Se (=0 J-CH 2 —CH═CH 2 . This surface has good biocompatibility and can bind strongly to a metallic surface. The polymer may be made from an electropolymerisable monomer, e.g. a pyrrole.

  一种医疗器械，例如支架，具有与体组织接触的表面，其中该表面具有生物相容性涂层层，该涂层层包括具有共价结合的烯丙基末端侧基的聚合物，所述侧基包括从-O-CH2-CH═ -S- -CH═ -S（=0）- -CH═ -Se- -CH═ 和-Se（=0 J- -CH═ 中选择的基团。该表面具有良好的生物相容性，并可以强烈地结合到金属表面上。该聚合物可以由电聚合单体制成，例如吡咯。
• Asymmetric induction reactions. V. The palladium-catalyzed asymmetric .alpha.-allylation of carbonyl compounds with chiral allyl esters via enamines and imines
  作者：Kunio Hiroi、Jun Abe、Kyoko Suya、Shuko Sato、Toshihiro Koyama

  DOI：10.1021/jo00080a033

  日期：1994.1

  A novel and excellent method for asymmetric alpha-allylation of carbonyl compounds via their chiral enamines or imines bearing allyl eaters has been developed. Readily available chiral allyl eaters having chirality at the alpha-position of the eater carbonyl group, such as (S)-proline and other (S)-alpha-amino acid allyl esters, have been found to serve as good asymmetric allylating reagents in palladium-catalyzed reactions of the chiral enamines and imines derived from them. The use of (S)-proline or (S)-valine allyl esters as the amino parts in the enamines or imines provided the highest optical yields of the corresponding alpha-allyl carbonyl compounds. A mechanism for asymmetric induction is proposed based on the stereochemical results obtained.
• Development of Powerful Auxiliary-Mediated Ligation To Facilitate Rapid Protein Assembly
  作者：Hongli Yin、Dan Lu、Siyao Wang、Ping Wang

  DOI：10.1021/acs.orglett.9b01737

  日期：2019.7.5

  Here, we describe an Se-auxiliary mediated ligation protocol capable of rapid native chemical ligations at sterically hindered junctions, followed by in situ auxiliary cleavage under neutral conditions without affecting unprotected Cys residues. This auxiliary, which is prepared from phenyl acetaldehyde in one step, can be conveniently attached to the N-terminal region of a peptide via a reductive amination or coupling reaction. We demonstrated this methodology by synthesizing two protein samples.
• HIROI, KUNIO;KOYAMA, TOSHIHIRO;ANZAI, KAORI, CHEM. LETT.,(1990) N, C. 235-238
  作者：HIROI, KUNIO、KOYAMA, TOSHIHIRO、ANZAI, KAORI

  DOI：——

  日期：——
• Food supplement for animals, comprising an olfactory additive
  申请人：Geraert Pierre-Andre

  公开号：US20070166356A1

  公开（公告）日：2007-07-19

  The present invention generally relates to the feeding of animals, and in particular to the complementation of this feeding with an active compound, i.e., an amino acid, or an amino acid derivative, for example methionine. The present invention in particular relates to a feed complement for animals comprising at least one amino acid or amino acid derivative and at least one olfactory additive.