N-maleoyl-DL-3-amino-2-methylpropionic acid | 676362-50-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-maleoyl-DL-3-amino-2-methylpropionic acid
• 英文别名: (Z)-4-(2-carboxypropylamino)-4-oxobut-2-enoic acid
• CAS: 676362-50-8
• 化学式: C₈H₁₁NO₅
• 分子量: 201.179
• InChiKey: ICWQYFHHCZYFBW-IHWYPQMZSA-N

物化性质

• 沸点：
  524.7±50.0 °C(Predicted)
• 密度：
  1.343±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-maleoyl-DL-3-amino-2-methylpropionic acid 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 3'-O-(N-maleimido-DL-3-amino-2-methylpropionyl)fluorescein
  参考文献：
  名称：

  General strategy for the preparation of membrane permeable fluorogenic peptide ester conjugates for in vivo studies of ester prodrug stability

  摘要：

  To study ester prodrug stability properties in living cells we have conjugated fluorogenic esters to the cell membrane permeable peptide Arg(9). The desired conjugates are prepared by coupling N-maleoyl amino acid esters of monoalkylated fluoresceins or fluorescein to TyrArg(9)Cys. The photophysical properties of the monoalkylated fluorescein derivatives are described. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.11.016
• 作为产物：
  描述：

  马来酸酐 、 3-氨基异丁酸 以 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 N-maleoyl-DL-3-amino-2-methylpropionic acid
  参考文献：
  名称：

  General strategy for the preparation of membrane permeable fluorogenic peptide ester conjugates for in vivo studies of ester prodrug stability

  摘要：

  To study ester prodrug stability properties in living cells we have conjugated fluorogenic esters to the cell membrane permeable peptide Arg(9). The desired conjugates are prepared by coupling N-maleoyl amino acid esters of monoalkylated fluoresceins or fluorescein to TyrArg(9)Cys. The photophysical properties of the monoalkylated fluorescein derivatives are described. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.11.016

文献信息

• US4320173A
  申请人：——

  公开号：US4320173A

  公开（公告）日：1982-03-16
• US4350740A
  申请人：——

  公开号：US4350740A

  公开（公告）日：1982-09-21
• US4374956A
  申请人：——

  公开号：US4374956A

  公开（公告）日：1983-02-22
• General strategy for the preparation of membrane permeable fluorogenic peptide ester conjugates for in vivo studies of ester prodrug stability
  作者：Xiaoxu Li、John Stephen Taylor

  DOI：10.1016/j.bmc.2003.11.016

  日期：2004.2

  To study ester prodrug stability properties in living cells we have conjugated fluorogenic esters to the cell membrane permeable peptide Arg(9). The desired conjugates are prepared by coupling N-maleoyl amino acid esters of monoalkylated fluoresceins or fluorescein to TyrArg(9)Cys. The photophysical properties of the monoalkylated fluorescein derivatives are described. (C) 2003 Elsevier Ltd. All rights reserved.