1-(4-(pyridin-2-yl)thiazol-2-yl)ethanone | 1180844-62-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-(pyridin-2-yl)thiazol-2-yl)ethanone
• 英文别名: 1-(4-Pyridin-2-yl-1,3-thiazol-2-yl)ethanone
• CAS: 1180844-62-5
• 化学式: C₁₀H₈N₂OS
• 分子量: 204.252
• InChiKey: OICASCYVFUUHIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯吡啶 、 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazol-2-yl]ethanone 在 potassium phosphate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 12.0h， 以84%的产率得到1-(4-(pyridin-2-yl)thiazol-2-yl)ethanone
  参考文献：
  名称：

  Highly Efficient Borylation Suzuki Coupling Process for 4-Bromo-2-ketothiazoles: Straightforward Access to Micrococcinate and Saramycetate Esters

  摘要：

  The first palladium-catalyzed borylation of 4-bromo-2-ketothiazoles followed by a Suzuki cross-coupling reaction with haloheteroaromatics using Buchwaid's Cy-JohnPhos and XPhos ligands is reported. The methodology has allowed the fast preparation of highly valuable 4-pyridinyl- and 4-thiazolyl-2-ketothiazoles as common subunits of thiopeptide antibiotics. As direct applications, novel concise syntheses of a sulfomycinamate thio-analogue as well as micrococcinate and saramycetate esters are described.

  DOI：

  10.1021/ol901525t

文献信息

• CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
  申请人：Carter Percy H.

  公开号：US20090124668A1

  公开（公告）日：2009-05-14

  The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.

  本申请描述了 MCP-1 的调节剂，其化学式为 (I) 或其药学上可接受的盐形式，适用于治疗类风湿性关节炎、多发性硬化症、动脉粥样硬化和哮喘。
• US7829571B2
  申请人：——

  公开号：US7829571B2

  公开（公告）日：2010-11-09
• Highly Efficient Borylation Suzuki Coupling Process for 4-Bromo-2-ketothiazoles: Straightforward Access to Micrococcinate and Saramycetate Esters
  作者：Thibaut Martin、Claire Laguerre、Christophe Hoarau、Francis Marsais

  DOI：10.1021/ol901525t

  日期：2009.8.20

  The first palladium-catalyzed borylation of 4-bromo-2-ketothiazoles followed by a Suzuki cross-coupling reaction with haloheteroaromatics using Buchwaid's Cy-JohnPhos and XPhos ligands is reported. The methodology has allowed the fast preparation of highly valuable 4-pyridinyl- and 4-thiazolyl-2-ketothiazoles as common subunits of thiopeptide antibiotics. As direct applications, novel concise syntheses of a sulfomycinamate thio-analogue as well as micrococcinate and saramycetate esters are described.