ethyl 3,6,9,12-tetraoxatridecanoate | 66664-66-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 3,6,9,12-tetraoxatridecanoate
• 英文别名: Ethyl 2,5,8,11-tetraoxatridecan-13-oate；ethyl 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]acetate
• CAS: 66664-66-2
• 化学式: C₁₁H₂₂O₆
• 分子量: 250.292
• InChiKey: QRCMBDCVJKWHOA-UHFFFAOYSA-N

物化性质

• 沸点：
  310.3±27.0 °C(Predicted)
• 密度：
  1.047±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  17
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  ethyl 3,6,9,12-tetraoxatridecanoate 在 sodium hydroxide 、 氯化亚砜 、 硫酸 作用下， 以 吡啶 、 水 为溶剂， 反应 32.0h， 生成 1,2-O-isopropylidene-3,5,6-tri-O-(3,6,9,12-tetraoxatridecanoyl)-α-D-glucofuranose
  参考文献：
  名称：

  Synthesis of some polyethers from carbohydrates derivatives and related compounds, and their interaction with sodium and pottasium cations

  摘要：

  DOI：

  10.1016/s0008-6215(00)83674-5
• 作为产物：
  描述：

  三甘醇单甲醚 、 溴乙酸乙酯 在 四丁基溴化铵 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以78.74%的产率得到ethyl 3,6,9,12-tetraoxatridecanoate
  参考文献：
  名称：

  [EN] NOVEL TRITERPENE DERIVATIVES AS HIV INHIBITORS
  [FR] NOUVEAUX DÉRIVÉS DE TRITERPÈNE EN TANT QU'INHIBITEURS DU VIH

  摘要：

  本发明涉及公式（I）的新型三萜衍生物；及其药学上可接受的盐，其中R1、R2、R3、R4和环如本文所定义。该发明还涉及新型三萜衍生物、相关化合物和药物组合物，用于治疗病毒性疾病，特别是HIV介导的疾病。

  公开号：

  WO2020165741A1

文献信息

• Novel alkanoic acid derivaties
  申请人：——

  公开号：US20040067202A1

  公开（公告）日：2004-04-08

  There are provided according to the invention compounds of the formula (I) or a salt or solvate thereof, wherein: n represents an integer 1 to 6; N represents an integer 1 to 15; R 1 represents (CO) x C 1-9 alkyl or (CO) x C 1-9 fluoroalkyl, which fluoroalkyl moiety contains at least 1 fluorine atom and not more than 3 consecutive perfluorocarbon atoms wherein x represents 0 or 1; and R 2 and R 3 independently represent C 1-3 alkyl or hydrogen. There are also provided pharmaceutical aerosol formulations employing said compounds as suspension stabilising agents.

  本发明提供了化合物(I)或其盐或溶剂，其中：n表示1至6的整数；N表示1至15的整数；R1表示(CO)xC1-9烷基或(CO)xC1-9氟烷基，其中氟烷基含有至少1个氟原子，但不超过3个连续的全氟碳原子，其中x表示0或1；R2和R3独立地表示C1-3烷基或氢。本发明还提供了以所述化合物作为悬浮稳定剂的制药气雾剂配方。
• Etherified triazolobenzodiazepine derivatives
  申请人：Ciba-Geigy Corporation

  公开号：US04178378A1

  公开（公告）日：1979-12-11

  Etherified diazepine derivatives of the formula ##STR1## in which R.sub.1 represents hydrogen or alkyl having up to 3 carbon atoms, R.sub.2 and R.sub.3 independently of one another each represent hydrogen or alkyl having up to 7 carbon atoms, or represent the partial formula R.sub.4 --(OCH.sub.2 --CH.sub.2).sub.m, in which R.sub.4 represents hydrogen or alkyl having up to 7 carbon atoms and m represents the number 1 to 3, A.sub.1 represents alkylidene or alkylene having up to 3 carbon atoms, A.sub.2, depending on the meaning of n, represents alkylene or alkanetriyl having up to 5 carbon atoms, no carbon atom in the radical A.sub.2 being bonded to more than one oxygen atom, n represents the number 0 or 1, Ph represents substituted or unsubstituted 1,2-phenylene and Ar represents an aromatic radical, and their addition salts are manufactured according to methods known per se. They are useful in the treatment of states of epilepsy, stress and agitation.

  公式为##STR1##的醚化二氮杂环衍生物，其中R.sub.1代表氢或具有至多3个碳原子的烷基，R.sub.2和R.sub.3各自独立地代表具有至多7个碳原子的氢或烷基，或代表部分式R.sub.4--(OCH.sub.2--CH.sub.2).sub.m，其中R.sub.4代表具有至多7个碳原子的氢或烷基，m代表1到3的数字，A.sub.1代表具有至多3个碳原子的烷基或亚烷基，A.sub.2根据n的含义而定，代表具有至多5个碳原子的亚烷基或烷基三基，A.sub.2中的任何碳原子都不与多于一个氧原子结合，n代表数字0或1，Ph代表取代或未取代的1,2-苯基，Ar代表芳基基团。它们的加成盐是按照已知方法制造的。它们在治疗癫痫、压力和不安状态方面是有用的。
• Alkanoic acid derivatives
  申请人：SmithKline Beecham Corporation

  公开号：US07217409B2

  公开（公告）日：2007-05-15

  A method for treating respiratory disorders comprises administering to a patient a pharmaceutical aerosol formulation comprising: (i) a compound of formula (I) or a salt or solvate thereof, wherein: n represents an integer 1 to 6; N represents an integer 1 to 15; R1 represents —(CO)xC1-9 alkyl or —(CO)xC1-9 fluoroalkyl, which fluoroalkyl moiety contains at least 1 fluorine atom and not more than 3 consecutive perfluorocarbon atoms wherein x represents 0 or 1; and R2 and R3 independently represent C1-3alkyl or hydrogen, (ii) at least one medicament, and (iii) at least one propellant.

  一种治疗呼吸系统疾病的方法包括向患者给予一种药物气雾剂制剂，该制剂包括：（i）式（I）的化合物或其盐或溶剂化物，其中：n代表1至6的整数；N代表1至15的整数；R1代表—（CO）xC1-9烷基或—（CO）xC1-9氟烷基，其中所述氟烷基官能团含有至少1个氟原子且不超过3个连续的全氟碳原子，其中x代表0或1；R2和R3分别代表C1-3烷基或氢，（ii）至少一种药物，和（iii）至少一种推进剂。
• Regulatory effect of hydroquinone–tetraethylene glycol conjugates on zebrafish pigmentation
  作者：Hoa Thi Le、Bin Na Hong、Yeong Ro Lee、Ji Hyun Cheon、Tong Ho Kang、Tae Woo Kim

  DOI：10.1016/j.bmcl.2015.09.059

  日期：2016.1

  We synthesized two hydroquinone-tetraethylene glycol conjugates (HQ-TGs) and investigated their logP, photophysical stability, and redox chemical stability. HQ-TGs are a little more hydrophilic than hydroquinone (HQ) and show an enhanced photophysical and redox chemical stability compared with HQ. In addition we studied the effect of HQ-TGs on cell viability and on zebrafish pigmentation. MTT assay in HF-16 cells showed HQ-TGs are less cytotoxic than HQ. The phenotype-based image analysis of zebrafish larvae suggests that HQ-TGs suppress the pigmentation of zebrafish in a dose-dependent manner. The comparative experiments on stability, cytotoxicity, and zebrafish pigmentation between HQ and HQ-TGs suggest that mono tetraethylene glycol-functionalization of HQ is an alternative solution to overcome the adverse effect of HQ. (C) 2015 Elsevier Ltd. All rights reserved.
• JP5717138
  申请人：——

  公开号：——

  公开（公告）日：——