6-oxo-3,6-diphenylhexanoic acid | 1257544-68-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-oxo-3,6-diphenylhexanoic acid
• 英文别名: 6-Oxo-3,6-diphenylhexanoic acid
• CAS: 1257544-68-5
• 化学式: C₁₈H₁₈O₃
• 分子量: 282.339
• InChiKey: MECPAKSBCKCZOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (4-苯基环己烯-1-基)苯 在 potassium peroxymonosulfate 、 碘苯 作用下， 以 水 、 乙腈 为溶剂， 反应 3.0h， 以65%的产率得到6-oxo-3,6-diphenylhexanoic acid
  参考文献：
  名称：

  Oxidative Cleavage of Alkenes Using an In Situ Generated Iodonium Ion with Oxone as a Terminal Oxidant

  摘要：

  A facile and operationally convenient catalytic procedure for oxidative cleavage of alkenes is described. In situ formed [hydroxy(4-carboxyphenyl)iodonium]ion, 2, from the oxidation of 4-iodobenzoic acid, 1, has been shown to facilitate the cleavage of a variety of alkenes in presence of Ozone as a co-oxidant. Optimization of the reaction conditions using 1-phenyl-1-cyclohexene, 3, and the competitive oxidative cleavage of different substrates using the optimized conditions has uncovered important mechanistic details of the reaction.

  DOI：

  10.1021/ol1023807

文献信息

• Oxidative Cleavage of Alkenes Using an In Situ Generated Iodonium Ion with Oxone as a Terminal Oxidant
  作者：Prem P. Thottumkara、Thottumkara K. Vinod

  DOI：10.1021/ol1023807

  日期：2010.12.17

  A facile and operationally convenient catalytic procedure for oxidative cleavage of alkenes is described. In situ formed [hydroxy(4-carboxyphenyl)iodonium]ion, 2, from the oxidation of 4-iodobenzoic acid, 1, has been shown to facilitate the cleavage of a variety of alkenes in presence of Ozone as a co-oxidant. Optimization of the reaction conditions using 1-phenyl-1-cyclohexene, 3, and the competitive oxidative cleavage of different substrates using the optimized conditions has uncovered important mechanistic details of the reaction.