o-butoxyallylbenzene | 28456-81-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: o-butoxyallylbenzene
• 英文别名: (2-allyl-phenyl)-butyl ether；(2-Allyl-phenyl)-butyl-aether；3-(2-n-Butoxyphenyl)-1-propene；1-butoxy-2-prop-2-enylbenzene
• CAS: 28456-81-7
• 化学式: C₁₃H₁₈O
• mdl: MFCD14582747
• 分子量: 190.285
• InChiKey: VIWFIIRXLSASOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.384
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  o-butoxyallylbenzene 在 吡啶 、 sodium tetrahydroborate 、 正丁基锂 、 氧气 、 三溴化磷 、 臭氧 、 三乙胺 作用下， 以 甲醇 、 乙醚 、 水 、 乙腈 为溶剂， 反应 148.75h， 生成 (+/-)-16-oxa-14,15-dinor-13,16-inter-o-phenyleneleucotriene E4 dimethyl ester
  参考文献：
  名称：

  Tolstikov, G. A.; Tolstikov, A. G.; Miftakhov, M. S., Journal of Organic Chemistry USSR (English Translation), 1986, vol. 22, # 8, p. 1457 - 1463

  摘要：

  DOI：
• 作为产物：
  描述：

  正溴丁烷 、 o-allylphenolate 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以70%的产率得到o-butoxyallylbenzene
  参考文献：
  名称：

  Tolstikov, G. A.; Tolstikov, A. G.; Miftakhov, M. S., Journal of Organic Chemistry USSR (English Translation), 1986, vol. 22, # 8, p. 1457 - 1463

  摘要：

  DOI：

文献信息

• Process for preparing 1-bromoalkylbenzene derivatives and intermediates thereof
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP0637580A1

  公开（公告）日：1995-02-08

  A 1-bromoalkylbenzene derivative is prepared by reacting a phenylalkene derivative with hydrogen bromide in the presence of a non-polar solvent. The phenylalkene derivative is prepared by reacting an alkenyl halide with metal magnesium to form a Grignard reagent, and then reacting the Grignard reagent with a benzyl halide derivative. An allyl Grignard reagent is prepared by reacting continuously an allyl halide derivative with metal magnesium in an organic solvent, in which the allyl halide derivative and metal magnesium are continuously added to the reaction system and the allyl Grignard reagent formed is continuously removed from the reaction system. The processes provide the intended compounds in high yields, high selectivities and high purities.

  1-bromoalkylbenzene derivative is prepared by reacting a phenylalkene derivative with hydrogen bromide in the presence of a non-polar solvent.苯基烷烃衍生物的制备方法是先使烯基卤化物与金属镁反应生成格氏试剂，然后使格氏试剂与苄基卤化物衍生物反应。烯丙基格氏试剂是通过烯丙基卤化物衍生物与金属镁在有机溶剂中连续反应制备的，其中烯丙基卤化物衍生物和金属镁被连续加入反应体系，形成的烯丙基格氏试剂被连续从反应体系中移除。这些工艺可提供高产率、高选择性和高纯度的预期化合物。
• [EN] SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING PAIN<br/>[FR] COMPOSÉS DÉRIVÉS DE SULFAMATE DESTINÉS À ÊTRE UTILISÉS POUR LE TRAITEMENT OU LE SOULAGEMENT DE LA DOULEUR
  申请人：BIO PHARM SOLUTIONS CO LTD

  公开号：WO2015088272A9

  公开（公告）日：2015-10-01
• JPH10279509A
  申请人：——

  公开号：JPH10279509A

  公开（公告）日：1998-10-20
• Sulfamate Derivative Compounds for Use in Treating or Alleviating Pain
  申请人：BIO-PHARM SOLUTIONS CO., LTD.

  公开号：US20160311792A1

  公开（公告）日：2016-10-27

  The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative compounds or a pharmaceutically acceptable salt thereof as an active ingredient. More specifically the present invention relates to a pharmaceutical composition for treating or alleviating pain containing a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or alleviation of pain comprising administering a sulfamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or alleviation of pain.
• US5637736A
  申请人：——

  公开号：US5637736A

  公开（公告）日：1997-06-10