β-L-idopyranose | 12773-33-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: β-L-idopyranose
• 英文别名: α-L-glucose；α-D-Mannopyranose；α-Mannopyranose；α-D-Mannose；(2S,3R,4S,5S,6S)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
• CAS: 12773-33-0
• 化学式: C₆H₁₂O₆
• 分子量: 180.158
• InChiKey: WQZGKKKJIJFFOK-ZSNZIGRDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  110
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  β-L-idopyranose 、 甲醇 、 盐酸 生成 (2S,3S,4S,5R,6S)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol
  参考文献：
  名称：

  KONIG, WILFRIED A.;MISCHNICK-LUBBECKE, PETRA;BRASSAT, BARBEL;LUTZ, SABINE+, CARBOHYDR. RES., 183,(1988) N 1, C. 11-17

  摘要：

  DOI：

文献信息

• Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors
  申请人：Academisch Ziekenhuis bij de Universiteit van Amsterdam

  公开号：EP1528056A1

  公开（公告）日：2005-05-04

  The invention provides a new class of deoxynojirimycin analogues, or pharmaceutically acceptable salts thereof which can suitably be used for the treatment of a disease selected from the group consisting of insulin resistance, Gauger disease, inflammatory diseases, hyperpigmentation and/or inflammatory skin conditions, overweight and obesity, lysosomal storage disorders, fungal diseases, melanoma and other tumors, and microbacterial infections. The invention further provides a pharmaceutical composition comprising said deoxynojirimycon analogue, or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

  该发明提供了一类新的脱氧诺吉霉素类似物，或其药学上可接受的盐，可用于治疗从胰岛素抵抗、高格氏病、炎症性疾病、多种病变和/或炎症性皮肤病变、超重和肥胖、溶酶体贮积疾病、真菌病、黑色素瘤和其他肿瘤，以及微生物感染等疾病中选择的疾病。该发明还提供了一种含有所述脱氧诺吉霉素类似物或其药学上可接受的盐以及药学上可接受的载体的药物组合物。
• [EN] DEOXYNOJIRIMYCIN ANALOGUES AND THEIR USES AS GLUCOSYLCERAMIDASE INHIBITORS<br/>[FR] ANALOGUES DE LA DESOXYNOJIRIMYCINE ET LEURS UTILISATIONS COMME INHIBITEURS DE LA GLUCOSYLCERAMIDASE
  申请人：AZ UNIV AMSTERDAM

  公开号：WO2005040118A1

  公开（公告）日：2005-05-06

  The invention provides a new class of deoxynojirimycin analogues, or pharmaceutically acceptable salts thereof which can suitably be used for the treatment of a disease selected from the group consisting of insulin resistance, Gauger disease, inflammatory diseases, hyperpigmentation and/or inflammatory skin conditions, overweight and obesity, lysosomal storage disorders, fungal diseases, melanoma and other tumors, and microbacterial infections. The invention further provides a pharmaceutical composition comprising said deoxynojirimycon analogue, or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

  本发明提供了一类新型的脱氧诺吉霉素类似物，或其药学上可接受的盐，可适用于治疗选自胰岛素抵抗、高加病、炎症性疾病、色素沉着和/或炎症性皮肤状况、超重和肥胖、溶酶体贮积症、真菌病、黑色素瘤和其他肿瘤、微生物感染的疾病。本发明还提供了一种包含所述脱氧诺吉霉素类似物或其药学上可接受的盐以及药学上可接受的载体的制药组合物。
• COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
  申请人：Janetka James W.

  公开号：US20120309701A1

  公开（公告）日：2012-12-06

  The present invention encompasses compounds and methods for treating urinary tract infections.

  本发明涵盖了治疗尿路感染的化合物和方法。
• DEVICE FOR AUTOMATED SYNTHESIS OF OLIGO- AND POLYSACCHARIDES
  申请人：Max-Planck-Gesellschat zu rFérderung der Wissenschaften e.V.

  公开号：US20220395800A1

  公开（公告）日：2022-12-15

  The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.

  本发明通常涉及自动合成技术，更具体地，涉及一种用于在固体支持上自动合成寡糖和多糖的装置和方法。特别是，本发明涉及一种用于在固体支持上自动合成寡糖和多糖的装置，包括反应容器、试剂储存组件、试剂输送系统、冷却装置用于冷却反应容器和预冷装置用于预冷待供应试剂的组成部分。
• METHOD AND DEVICE FOR PRODUCING SACCHARIDES AND SACCHARIDE ARRAYS
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3670521A1

  公开（公告）日：2020-06-24

  The present invention relates to a method and a device for producing saccharides and saccharide arrays. Said method is particularly useful for the synthesis of saccharides in parallel and of high-density saccharide arrays, such as microarrays, which are required for high-throughput screenings.

  本发明涉及一种生产糖和糖阵列的方法和装置。该方法特别适用于平行合成糖类和高密度糖类阵列，如高通量筛选所需的微阵列。