allyl dichloroacetate | 30895-77-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: allyl dichloroacetate
• 英文别名: Dichlor-essigsaeure-allylester；prop-2-enyl 2,2-dichloroacetate
• CAS: 30895-77-3
• 化学式: C₅H₆Cl₂O₂
• 分子量: 169.007
• InChiKey: UJUPTENXDPFFDP-UHFFFAOYSA-N

物化性质

• 保留指数：
  946;946

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  allyl dichloroacetate 在 RhCl(PPh₃)3 作用下， 以 1,4-二氧六环 为溶剂， 以15%的产率得到2-methylene-4-pentenyl dichloroacetate
  参考文献：
  名称：

  Miyamo, Sotaro; Mori, Atsuo; Kato, Katsumi, Chemistry Letters, 1982, p. 1379 - 1382

  摘要：

  DOI：
• 作为产物：
  描述：

  trichloro-acetic acid allyl ester 在 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 苯 为溶剂， 反应 4.0h， 生成 allyl dichloroacetate
  参考文献：
  名称：

  Cyclization of allyl α-halocarboxylates in the presence of metallocomplex initiators

  摘要：

  Allyl trichloroacetate and allyl 2,2-dichloropropionate, unlike allyl bromoacetate and allyl 2-bromopropionate, undergo cyclization into gamma-lactones in the presence of a Fe(CO)(5)-amide system. All these esters undergo reductive dehalogenation under the action of the Bu(n)(3)SnH-AIBN system.

  DOI：

  10.1007/bf02495209

文献信息

• Bis(π-allylnickel haloacetates)
  作者：F. Dawans、J.C. Marechal、Ph. Teyssie

  DOI：10.1016/s0022-328x(00)90619-3

  日期：1970.1

  The synthesis and the physico-chemical properties of a series of bis(π-allyl-nickel haloacetates), which were found to be very efficient catalysts for the 1,4-stereo- specific polymerization of 1,3-butadiene, are reported.

  报道了一系列双（π-烯丙基-卤代乙酸镍）的合成和理化性质，发现它们是1,3-丁二烯1,4-立体特异性聚合的非常有效的催化剂。
• METHOD FOR PRODUCING CARBOXYLIC ACID COMPOUND
  申请人：Kowa Company, Ltd.

  公开号：EP2003112A1

  公开（公告）日：2008-12-17

  A method for conveniently preparing 2,2-dichloro-12-(4-chlorophenyl)-10-hydroxydodecanoic acid useful as an active ingredient of therapeutic agents for diseases such as diabetes at a high yield, which comprises the step of reacting a compound represented by the following general formula (A): wherein X represents a halogen atom, and a compound represented by the following general formula (B): CHCl2COOR1 wherein R1 represents hydrogen atom or a protective group of carboxyl group, to prepare a compound represented by the following general formula (C): wherein R1 has the same meaning as that defined above.

  一种方便地制备2,2-二氯-12-(4-氯苯基)-10-羟基十二烷酸的方法，该方法可用于治疗糖尿病等疾病的治疗剂，且产率高，包括以下步骤：将下列通式(A)所表示的化合物与下列通式(B)所表示的化合物反应，其中X代表卤素原子，R1代表氢原子或羧基的保护基，以制备下列通式(C)所表示的化合物，其中R1的含义与上述相同。
• Process for preparing acids via alpha-chloroepoxy esters
  申请人：SmithKline Beecham Corporation

  公开号：US20040220424A1

  公开（公告）日：2004-11-04

  This invention relates to a method for preparing certain acids of formula (I) via a chloroepoxy ester, which are useful as phosphodiesterase 4 inhibitors. 1

  本发明涉及一种通过氯氧环酯制备式(I)某些酸的方法，其作为磷酸二酯酶4抑制剂具有用途。
• METHOD FOR PREPARING CARBOXYLIC ACID COMPOUND
  申请人：Katsurada Manabu

  公开号：US20100261933A1

  公开（公告）日：2010-10-14

  A method for conveniently preparing 2,2-dichloro-12-(4-chlorophenyl)-10-hydroxydodecanoic acid useful as an active ingredient of therapeutic agents for diseases such as diabetes at a high yield, which comprises the step of reacting a compound represented by the following general formula (A): wherein X represents a halogen atom, and a compound represented by the following general formula (B): CHCl 2 COOR 1 wherein R 1 represents hydrogen atom or a protective group of carboxyl group, to prepare a compound represented by the following general formula (C): wherein R 1 has the same meaning as that defined above.

  一种制备2,2-二氯-12-(4-氯苯基)-10-羟基十二酸的方法，该化合物可用作治疗糖尿病等疾病的活性成分，且得率高。该方法包括将下述通式（A）所代表的化合物（其中X代表卤素原子）与下述通式（B）所代表的化合物（其中R1代表氢原子或羧基的保护基）反应，以制备下述通式（C）所代表的化合物（其中R1具有与上述定义相同的含义）。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Ni: Org.Verb.2, 2.3.1, page 271 - 289
  作者：

  DOI：——

  日期：——

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