20-OTES-5-OH-camptothecin | 1122498-28-5

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 喜树碱
• 英文名称: 20-OTES-5-OH-camptothecin
• 英文别名: (19S)-19-ethyl-12-hydroxy-19-triethylsilyloxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• CAS: 1122498-28-5
• 化学式: C₂₆H₃₀N₂O₅Si
• 分子量: 478.62
• InChiKey: SEDNCAVRHZQGDI-NASUQTAISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  89
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  20-OTES-5-OH-camptothecin 在 triethylamine tris(hydrogen fluoride) 作用下， 以 四氢呋喃 为溶剂， 生成 5-hydroxycamptothecin
  参考文献：
  名称：

  Semisynthesis, Biological Activity, and Molecular Modeling Studies of C-Ring-Modified Camptothecins

  摘要：

  The synthesis, biological activity, and molecular modeling studies of C-ring-rnodified camptothecins are reported. A general synthetic protocol, based on "C-5 camptothecin (C-5-CPT) enolate chemistry", allows one to obtain various C5-substituted analogues. All new Compounds, obtained as 1:1 epimeric mixtures, were tested for their antiproliferative activity. Experimental data showed that all novel derivatives are less active than the reference compounds and that one of the two epimers; is more active than the other. Molecular docking simulations were performed to achieve more insight into the interactions between the new C5-modified CPTs and Topo I. A good correlation was observed when the data of cytotoxicity and the values calculated for the free binding energy were combined.

  DOI：

  10.1021/jm801153y
• 作为产物：
  描述：

  20(S)-O-triethylsilylcamptothecin 在 lithium hexamethyldisilazane 、 2-(Phenylsulfonyl)-3-phenyloxaziridin 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以95%的产率得到20-OTES-5-OH-camptothecin
  参考文献：
  名称：

  Semisynthesis, Biological Activity, and Molecular Modeling Studies of C-Ring-Modified Camptothecins

  摘要：

  The synthesis, biological activity, and molecular modeling studies of C-ring-rnodified camptothecins are reported. A general synthetic protocol, based on "C-5 camptothecin (C-5-CPT) enolate chemistry", allows one to obtain various C5-substituted analogues. All new Compounds, obtained as 1:1 epimeric mixtures, were tested for their antiproliferative activity. Experimental data showed that all novel derivatives are less active than the reference compounds and that one of the two epimers; is more active than the other. Molecular docking simulations were performed to achieve more insight into the interactions between the new C5-modified CPTs and Topo I. A good correlation was observed when the data of cytotoxicity and the values calculated for the free binding energy were combined.

  DOI：

  10.1021/jm801153y

文献信息

• Semisynthesis, Biological Activity, and Molecular Modeling Studies of C-Ring-Modified Camptothecins
  作者：Cristian Samorì、Andrea Guerrini、Greta Varchi、Gabriele Fontana、Ezio Bombardelli、Stella Tinelli、Giovanni Luca Beretta、Serena Basili、Stefano Moro、Franco Zunino、Arturo Battaglia

  DOI：10.1021/jm801153y

  日期：2009.2.26

  The synthesis, biological activity, and molecular modeling studies of C-ring-rnodified camptothecins are reported. A general synthetic protocol, based on "C-5 camptothecin (C-5-CPT) enolate chemistry", allows one to obtain various C5-substituted analogues. All new Compounds, obtained as 1:1 epimeric mixtures, were tested for their antiproliferative activity. Experimental data showed that all novel derivatives are less active than the reference compounds and that one of the two epimers; is more active than the other. Molecular docking simulations were performed to achieve more insight into the interactions between the new C5-modified CPTs and Topo I. A good correlation was observed when the data of cytotoxicity and the values calculated for the free binding energy were combined.