6-bromo-7,8-dimethoxy-3-methyl-1-m-tolyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine | 496769-47-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 6-bromo-7,8-dimethoxy-3-methyl-1-m-tolyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine
• 英文别名: 9-Bromo-7,8-dimethoxy-3-methyl-5-(3-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepine
• CAS: 496769-47-2
• 化学式: C₂₀H₂₄BrNO₂
• 分子量: 390.32
• InChiKey: NFTCTVHSUIBMII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-bromo-7,8-dimethoxy-3-methyl-1-m-tolyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine 、 3-甲基苯硼酸 在 potassium phosphate 、 palladium diacetate 、 三(邻甲基苯基)磷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D1 receptor activities

  摘要：

  A series of racemic 6-aryl substituted 1-phenylbenzazepines 7a-e, and 17a,b were prepared. All these compounds showed binding potencies compatible to or much higher than that of the prototypic (+/-)-SKF- 38393 ((+/-)-1) and (+/-)-SKF-83959 (3) for the D(1) receptor. Among analogs of (+/-)-SKF-38393, compounds 7b, 7c and 7e possess 10-, 2- and 7-fold enhancement in binding for the D(1) receptor, respectively. Lower but compatible potency to that of (+/-)-1 was observed for compounds 7a and 7d. The optimal 6-substituents (m-tolyl, and 2 '-naphthyl) were applied to the skeleton of (+/-)-SKF-83959 (3). The resulting compounds 17a, b displayed high affinity at the D(1) receptor, only slightly lower than that of (3). These two compounds also showed good binding at the D(2) receptor. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.09.049
• 作为产物：
  描述：

  7,8-dimethoxy-1-(o-tolyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine 、 三聚乙醛 在 盐酸 、 溴 、 溶剂黄146 、 甲酸 作用下， 以 水 为溶剂， 以51.5%的产率得到6-bromo-7,8-dimethoxy-3-methyl-1-m-tolyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine
  参考文献：
  名称：

  Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D1 receptor activities

  摘要：

  A series of racemic 6-aryl substituted 1-phenylbenzazepines 7a-e, and 17a,b were prepared. All these compounds showed binding potencies compatible to or much higher than that of the prototypic (+/-)-SKF- 38393 ((+/-)-1) and (+/-)-SKF-83959 (3) for the D(1) receptor. Among analogs of (+/-)-SKF-38393, compounds 7b, 7c and 7e possess 10-, 2- and 7-fold enhancement in binding for the D(1) receptor, respectively. Lower but compatible potency to that of (+/-)-1 was observed for compounds 7a and 7d. The optimal 6-substituents (m-tolyl, and 2 '-naphthyl) were applied to the skeleton of (+/-)-SKF-83959 (3). The resulting compounds 17a, b displayed high affinity at the D(1) receptor, only slightly lower than that of (3). These two compounds also showed good binding at the D(2) receptor. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.09.049

文献信息

• Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D1 receptor activities
  作者：Jing Zhang、Xuetao Chen、Leiping Yu、Xuechu Zhen、Ao Zhang

  DOI：10.1016/j.bmc.2008.09.049

  日期：2008.11

  A series of racemic 6-aryl substituted 1-phenylbenzazepines 7a-e, and 17a,b were prepared. All these compounds showed binding potencies compatible to or much higher than that of the prototypic (+/-)-SKF- 38393 ((+/-)-1) and (+/-)-SKF-83959 (3) for the D(1) receptor. Among analogs of (+/-)-SKF-38393, compounds 7b, 7c and 7e possess 10-, 2- and 7-fold enhancement in binding for the D(1) receptor, respectively. Lower but compatible potency to that of (+/-)-1 was observed for compounds 7a and 7d. The optimal 6-substituents (m-tolyl, and 2 '-naphthyl) were applied to the skeleton of (+/-)-SKF-83959 (3). The resulting compounds 17a, b displayed high affinity at the D(1) receptor, only slightly lower than that of (3). These two compounds also showed good binding at the D(2) receptor. (C) 2008 Elsevier Ltd. All rights reserved.