(3S,4R,5R)-2,2-difluoro-3,4,5,6-tetrahydroxyhexanal | 38440-80-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3S,4R,5R)-2,2-difluoro-3,4,5,6-tetrahydroxyhexanal
• CAS: 38440-80-1
• 化学式: C₆H₁₀F₂O₅
• 分子量: 200.14
• InChiKey: AQOQCRQQDZHTMX-WDCZJNDASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Inhibitors of Glycolysis Useful In the Treatment of Brain Tumors
  申请人：Priebe Waldemar

  公开号：US20110003758A1

  公开（公告）日：2011-01-06

  Provided herein are methods of treating brain tumors by administering a therapeutically effective amount of a compound of the Formulas I or II to a patient in need thereof.

  本文提供了一种通过向需要治疗的患者给予公式I或II的化合物的治疗性有效量来治疗脑肿瘤的方法。
• Hedgehog signaling pathway involved in energy metabolism
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP2620142A1

  公开（公告）日：2013-07-31

  The present invention relates to a modulator of the Smoothened (Smo) receptor capable of altering cellular glucose uptake for use in the treatment of a disease, wherein (a) the modulator is an activator of the Smoothened (Smo) receptor capable of increasing cellular glucose uptake and is for use in the treatment of diabetes, glucose intolerance, hyperglycemia, obesity, overweight, sepsis and diseases associated therewith; or (b) wherein the modulator is an inhibitor of the Smoothened (Smo) receptor capable of decreasing cellular glucose uptake and is for use in the treatment of hypoglycaemia. Further, the invention relates to a method of altering the glucose uptake, the lactate level, the NAD+/NADH ratio and/or the NADP+/NADPH ratio of a cell and a method of identifying a modulator of the Smoothened (Smo) receptor capable of altering the glucose uptake, the lactate level, the NAD+/NADH ratio and/or the NADP+/NADPH ratio of a cell. Also, the invention relates to a method of increasing uptake of glucose or a glucose analogue labelled with a detectable moiety.

  本发明涉及一种能够改变细胞葡萄糖摄取的 Smoothened (Smo) 受体的调节剂，用于治疗疾病，其中(a)调节剂是能够增加细胞葡萄糖摄取的 Smoothened (Smo) 受体的激活剂，用于治疗糖尿病、葡萄糖不耐受症、高血糖症、肥胖症、超重、败血症和与之相关的疾病；或 (b) 其中的调节剂是能够减少细胞葡萄糖摄取的 Smoothened（Smo）受体抑制剂，用于治疗低血糖症。此外，本发明还涉及一种改变细胞葡萄糖摄取、乳酸盐水平、NAD+/NADH 比率和/或 NADP+/NADPH 比率的方法，以及一种鉴定能够改变细胞葡萄糖摄取、乳酸盐水平、NAD+/NADH 比率和/或 NADP+/NADPH 比率的 Smoothened (Smo) 受体调节剂的方法。此外，本发明还涉及一种增加葡萄糖或标记有可检测分子的葡萄糖类似物摄取量的方法。
• PHARMACEUTICAL COMPOSITION AND TUMOR IMMUNOACTIVITY PROMOTER
  申请人：Sentan Pharma Inc.

  公开号：EP3646875A1

  公开（公告）日：2020-05-06

  The present disclosure provides a pharmaceutical composition including biocompatible particles containing a sugar derivative, wherein the biocompatible particles contain a lactic acid-glycolic acid copolymer. The pharmaceutical composition may be used in combination with an anticancer drug.

  本公开提供了一种药物组合物，包括含有糖衍生物的生物相容性颗粒，其中生物相容性颗粒含有乳酸-乙醇酸共聚物。该药物组合物可与抗癌药物结合使用。
• Reprogramming of cells to a new fate
  申请人：The Scripps Research Institute

  公开号：US10308912B2

  公开（公告）日：2019-06-04

  The present invention generally provides methods and compositions for transdifferentiation of an animal cell from a first non-pluripotent cell fate to a second non-pluripotent cell fate. Also provided are methods and compositions for the transdifferentiation of an animal cell from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.

  本发明一般提供动物细胞从第一种非全能细胞命运向第二种非全能细胞命运转分化的方法和组合物。本发明还提供了将动物细胞从非多能中胚层、内胚层或外胚层细胞命运转分化为不同的非多能中胚层、内胚层或外胚层细胞命运的方法和组合物。
• Glucose conjugated gold nanoparticle
  申请人：Bar-Ilan University

  公开号：US10478132B2

  公开（公告）日：2019-11-19

  Composition methods and kits for diagnosing and treating tumors within a subject. The compositions disclosed comprise: a gold nanoparticle; PEG or derivatives thereof, wherein said PEG or derivatives thereof have a molecular weight of 400 to 1500 Dalton; and a 2-Deoxy-D-glucose, wherein the PEG or derivatives thereof are linked to the gold nanoparticle and to said 2-Deoxy-D-Glucose, and wherein the 2-Deoxy-D-Glucose is linked to the PEG or derivatives thereof at the 2-Carbon position of the 2-Deoxy-D-Glucose.

  用于诊断和治疗受试者体内肿瘤的组合物方法和试剂盒。所公开的组合物包括：金纳米粒子；PEG 或其衍生物，其中所述 PEG 或其衍生物的分子量为 400 至 1500 道尔顿；以及 2-脱氧-D-葡萄糖，其中所述 PEG 或其衍生物与金纳米粒子和所述 2-脱氧-D-葡萄糖相连，并且所述 2-脱氧-D-葡萄糖在 2-脱氧-D-葡萄糖的 2 碳位置与 PEG 或其衍生物相连。