2-ethyl-3-propylindole | 204206-21-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-ethyl-3-propylindole
• 英文别名: 2-ethyl-3-propyl-1H-indole
• CAS: 204206-21-3
• 化学式: C₁₃H₁₇N
• 分子量: 187.285
• InChiKey: JHZBMACTRVXOOB-UHFFFAOYSA-N

物化性质

• 沸点：
  319.2±11.0 °C(Predicted)
• 密度：
  1.017±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  正丁基锂 、 苯肼,盐酸盐 、 丙腈 在 溶剂黄146 作用下， 以 乙醚 为溶剂， 以23%的产率得到2-ethyl-3-propylindole
  参考文献：
  名称：

  Multiple component Fischer indole reactions

  摘要：

  New 3-component variations of the Fischer synthesis of substituted indoles have been developed based on the reaction of organometallic reagents with nitriles or carboxylic acids. The new variations expand the scope and synthetic utility of the method. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.08.062

文献信息

• Fischer Indole Synthesis over Hydrous Zirconia-Supported Niobium Oxide
  作者：Liang Zhong、Gaik-Khuan Chuah

  DOI：10.1071/ch09237

  日期：——

  Supported niobium oxides are investigated as green catalysts for Fischer indole reaction. By means of wet impregnation, 10–40 wt-% Nb2O5 were loaded onto hydrous zirconia as a support. Pore size distribution curves showed that the niobium oxide overlayer was uniformly dispersed onto the mesoporous support. Samples with close to a monolayer coverage of niobium oxide had the highest activity in the Fischer indole reaction of phenylhydrazine with both 3-heptanone and cyclohexanone. A coverage higher than a monolayer led to lower activity. In comparison, the supported catalysts were more active than bulk niobium oxide or a sample prepared by co-precipitation of hydrous zirconia and niobium oxide.

  研究了作为费舍尔吲哚反应绿色催化剂的负载铌氧化物。通过湿法浸渍，10-40 wt-% 的氧化铌被负载到作为载体的无水氧化锆上。孔径分布曲线显示，氧化铌覆盖层均匀地分散在介孔支持物上。在苯肼与 3- 庚酮和环己酮的费舍尔吲哚反应中，氧化铌单层覆盖率接近的样品活性最高。覆盖率高于单层时，活性较低。相比之下，支撑催化剂的活性高于块状氧化铌或通过水合氧化锆和氧化铌共沉淀制备的样品。
• BETA-CARBOLINE, DIHYDRO-BETA-CARBOLINE AND TETRAHYDRO-BETA-CARBOLINE ALKALOID DERIVATIVES, METHOD FOR PREPARING THE SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, AS FUNGICIDES AND INSECTICIDES
  申请人：Nankai University

  公开号：EP3459950A1

  公开（公告）日：2019-03-27

  The present invention relates to β-carboline, dihydro-β-carboline and tetrahydro-β-carboline alkaloid derivatives (I), a method for preparing the same and their use as fungicide, insecticide and in preventing and treating plant virus infections. For the meaning of each group in formula (I) see the description. The β-carboline, dihydro-β-carboline and tetrahydro-β-carboline alkaloid derivatives of the present invention show a particularly pronounced anti-plant virus activity, and also have fungicidal and insecticidal activities.

  本发明涉及β-咔啉、二氢-β-咔啉和四氢-β-咔啉生物碱衍生物(I)、其制备方法及其作为杀真菌剂、杀虫剂以及预防和治疗植物病毒感染的用途。式（I）中各基团的含义见说明。本发明的β-咔啉、二氢-β-咔啉和四氢-β-咔啉生物碱衍生物具有特别明显的抗植物病毒活性，同时还具有杀真菌和杀虫活性。
• METHOD OF TREATING ELEVATED PLASMA CHOLESTEROL
  申请人：Institut de Cardiologie de Montréal

  公开号：EP4011877A2

  公开（公告）日：2022-06-15

  The present invention relates to compounds of Table 1, which are encompassed by Formula I and/or Formula II, III, IV, V, or VI, and pharmaceutically acceptable salts, solvates or compositions thereof. Compounds of Table 1 are PCSK9 interacting small molecules that modulate PCSK9 activity and significantly increase low density lipoprotein receptor expression and activity, lower total circulating cholesterol and are useful for treating and delaying the onset of diseases that are associated with elevated cholesterol.

  本发明涉及由式I和/或式II、III、IV、V或VI所包含的表1化合物及其药学上可接受的盐、溶液或组合物。表 1 的化合物是 PCSK9 相互作用的小分子，可调节 PCSK9 活性，显著增加低密度脂蛋白受体的表达和活性，降低循环中的总胆固醇，并可用于治疗和延缓与胆固醇升高相关的疾病的发生。
• Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity
  申请人：Northwestern University

  公开号：US10934270B2

  公开（公告）日：2021-03-02

  Disclosed are new small molecules having a substituted quinazoline core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules or activated glucocerebrosidase conjugated to the small molecules, which compositions may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease.

  公开了具有取代的喹唑啉核心结构的新小分子及其在调节葡萄糖脑苷脂酶活性方面的用途。还公开了包含这些小分子或与这些小分子共轭的活化葡萄糖脑苷脂的药物组合物，这些组合物可用于治疗与葡萄糖脑苷脂活性有关的疾病或紊乱，包括神经系统疾病和紊乱，如戈谢病和帕金森病。
• US9040506B2
  申请人：——

  公开号：US9040506B2

  公开（公告）日：2015-05-26