Ethylidene bis-16-hydroxyhexadecanoate | 162582-23-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Ethylidene bis-16-hydroxyhexadecanoate
• 英文别名: Ethylidene bis(16-hydroxyhexadecanoate)；1-(16-hydroxyhexadecanoyloxy)ethyl 16-hydroxyhexadecanoate
• CAS: 162582-23-2
• 化学式: C₃₄H₆₆O₆
• 分子量: 570.894
• InChiKey: CROLNSXOPSNSFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12
• 重原子数：
  40
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-二甲氨基吡啶 、 Ethylidene bis-16-hydroxyhexadecanoate 在 乙酸酐 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以1.07 g (94%)的产率得到Ethylidene bis(16-acetoxyhexadecanoate)
  参考文献：
  名称：

  Dry microparticles for use as a contrast agent

  摘要：

  微粒对比剂包括气体或气体前体被非聚合物和不可聚合的壁材料封装，是易于表征的材料，具有令人惊讶的结构完整性和稳定性。

  公开号：

  US06274120B1

文献信息

• Contrast agents
  申请人：Ostensen Jonny

  公开号：US20050118104A1

  公开（公告）日：2005-06-02

  Ultrasonic visualisation of a suject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.

  使用新型气体含量对比剂制剂进行超声可视化检查，特别是对心肌和其他组织的灌注进行检查，这些制剂可以促进在体内可控和暂时的气相生长，并因此可以作为沉积的灌注示踪剂。这些制剂包括一种可共同给予的组合物，其中包括一种可向分散的气相内部扩散的可扩散成分，以促进其暂时生长。在心脏灌注成像中，这些制剂可以有利地与血管扩张药物（如腺苷）共同给予，以增强正常和低灌注心肌组织的回波信号强度差异。
• Use of particulate contrast agents in diagnostic imaging for studying physiological paramaters
  申请人：Fossheim Lise Sigrid

  公开号：US20050136002A1

  公开（公告）日：2005-06-23

  The present invention relates to a method of imaging of an animate human or non-human animal body, which method comprises: administering parenterally to said body a particulate material comprising a matrix or membrane material and at least one contrast generating species, which matrix or membrane material is responsive to a pre-selected physiological parameter whereby to alter the contrast efficacy of said species in response to a change in the value of said parameter; generating image data of at least part of said body in which said species is present; and generating therefrom a signal indicative of the value or variation of said parameter in said part of said body. The invention also relates to contrast media for imaging a physioloogical parameter.

  本发明涉及一种用于成像活体人类或非人类动物体的方法，该方法包括：将包含基质或膜材料和至少一种对比产生物的颗粒材料经肠外途径注入到该体内，其中所述基质或膜材料对预选生理参数具有响应性，以便在所述参数值发生变化时改变所述物种的对比效能；在存在所述物种的至少一部分体内生成图像数据；并从中生成一个信号，该信号指示所述部位体内所述参数的值或变化。本发明还涉及用于成像生理参数的对比介质。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Contrast agents comprising gas-containing or gas-generating polymer
  申请人：Nycomed Imaging AS

  公开号：US05674468A1

  公开（公告）日：1997-10-07

  Contrast agents comprising gas-containing or gas-generating polymer microparticles and/or microballoons, in which the polymer is a biodegradable polymer containing units of formula --(O).sub.m --CO--O--C(R.sup.1 R.sup.2)--O--CO--(O).sub.n -- (wherein R.sup.1 and R.sup.2 each represent hydrogen or a carbon-attached monovalent organic group or together form a carbon-attached divalent organic group, and m and n are each independently zero or one) may be used in diagnostic applications such as ultrasound and MR imaging.

  对比剂包括含气或产生气体的聚合物微粒和/或微气泡，其中聚合物是含有公式--（O）.sub.m--CO--O--C（R.sup.1R.sup.2）--O--CO--（O）.sub.n--（其中R.sup.1和R.sup.2分别表示氢或碳连接的一价有机基团或一起形成碳连接的二价有机基团，m和n分别独立地为零或一）的可生物降解聚合物，可用于诊断应用，如超声和MR成像。
• Separation processes
  申请人：NYCOMED IMAGING AS

  公开号：US20030104359A1

  公开（公告）日：2003-06-05

  Separation of target material from a liquid sample is achieved by coupling the target to targetable encapsulated gas microbubbles, allowing the microbubbles and coupled target to float to the surface of the sample to form a floating microbubble/target layer, and separating this layer from the sample. In a positive separation process the microbubbles are then removed from the target, e.g. by bursting. In a negative separation process target-free sample material is recovered following separation of the floating layer. The method may also be used diagnostically to detect the presence of a disease marker in a sample. Novel separation apparatus is also described.

  将目标物质从液体样品中分离的方法是将目标物质与可靶向的封装气体微泡耦合，使微泡和耦合的目标物质浮到样品表面形成浮动的微泡/目标物质层，并将该层与样品分离。在正分离过程中，微泡随后从目标物质中移除，例如通过爆裂。在负分离过程中，在分离浮动层后，可以回收无目标物质的样品材料。该方法还可用于诊断性地检测样品中疾病标志物的存在。还描述了新颖的分离装置。