9-oxo-9H-fluorene-2,7-diyl diacetate | 53133-99-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9-oxo-9H-fluorene-2,7-diyl diacetate
• 英文别名: (7-Acetyloxy-9-oxofluoren-2-yl) acetate
• CAS: 53133-99-6
• 化学式: C₁₇H₁₂O₅
• mdl: MFCD00405584
• 分子量: 296.279
• InChiKey: VPDHHSTYXKYGKQ-UHFFFAOYSA-N

物化性质

• 熔点：
  224.5-226.5 °C(Solv: ethanol (64-17-5))
• 沸点：
  498.0±38.0 °C(Predicted)
• 密度：
  1.346±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  9-oxo-9H-fluorene-2,7-diyl diacetate 在 platinum(IV) oxide 氯仿 、 氢气 、 sodium hydride 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 20.0 ℃ 、344.74 kPa 条件下， 反应 0.25h， 生成
  参考文献：
  名称：

  Chronobiotic activity of N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]-propanamide. Synthesis and melatonergic pharmacology of fluoren-9-ylethyl amides

  摘要：

  A series of fluoren-9-yl ethyl amides (2) were synthesized and evaluated for human melatonin MT1 and MT2 receptor binding. N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]propanamide (2b) was selected and evaluated in functional assays measuring intrinsic activity at the human MT1 and MT2 receptors and demonstrated full agonism at both receptors. The chronobiotic properties of 2b were demonstrated in both acute and chronic rat models where 2b produced an acute phase advance of 32 min at 1 mg/kg and chronically entrained free-running rats with a mean effective dose of 0.23 mg/kg. Compound 2b is significantly less efficacious than melatonin in constricting human coronary artery. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.07.002
• 作为产物：
  描述：

  methyl 5-acetoxy-2-bromobenzoate 在 tris-(dibenzylideneacetone)dipalladium(0) sodium hydroxide 、 氯化亚砜 、 sodium carbonate 作用下， 以 乙二醇二甲醚 、 乙醇 、 水 为溶剂， 生成 9-oxo-9H-fluorene-2,7-diyl diacetate
  参考文献：
  名称：

  Chronobiotic activity of N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]-propanamide. Synthesis and melatonergic pharmacology of fluoren-9-ylethyl amides

  摘要：

  A series of fluoren-9-yl ethyl amides (2) were synthesized and evaluated for human melatonin MT1 and MT2 receptor binding. N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]propanamide (2b) was selected and evaluated in functional assays measuring intrinsic activity at the human MT1 and MT2 receptors and demonstrated full agonism at both receptors. The chronobiotic properties of 2b were demonstrated in both acute and chronic rat models where 2b produced an acute phase advance of 32 min at 1 mg/kg and chronically entrained free-running rats with a mean effective dose of 0.23 mg/kg. Compound 2b is significantly less efficacious than melatonin in constricting human coronary artery. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.07.002

文献信息

• [EN] COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING DERIVATIVES OF FLUORENE<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE PRODUCTION DE CELLULES SOUCHES HÉMATOPOÏÉTIQUES EXPANSÉES METTANT EN OEUVRE DES DÉRIVÉS DE FLUORÈNE
  申请人：TRANSFUSION HEALTH LLC

  公开号：WO2019084452A1

  公开（公告）日：2019-05-02

  This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CD34+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.

  这项发明涉及一些内容，包括用于维持、增强和扩展来源于一个或多个CD34+细胞源的造血干细胞的化合物、方法、系统和组合物。CD34+细胞的来源包括骨髓、脐带血、动员的外周血和非动员的外周血。本文还提供了一些Formula I的化合物，这些化合物在维持、增强和扩展造血干细胞方面是有用的。
• New synthetic routes to tilorone dihydrochloride and some of its analogs
  作者：Helen M. Burke、Madeleine M. Joullie

  DOI：10.1021/jm00208a016

  日期：1978.10

  New synthetic routes to the orally active, interferon-inducing antiviral agent tilorone dihydrochloride, 2,7-bis-[(diethylamino)ethoxy]fluoren-9-one dihydrochloride (1a), were developed. The routes involved the preparation and solvolysis of tetrazonium fluoroborate salts of 2,7-diaminofluoren-9-one. Nonplanar (1b), 9-sulfone (1c), and fluorene (1d) analogues of tilorone dihydrochloride were also prepared

  已开发出新的合成途径，以合成口服活性的，可诱导干扰素的抗病毒剂，盐酸替洛龙，2,7-双-[（（二乙基氨基）乙氧基]芴-9-二氢呋喃酮（1a）。路线涉及2,7-二氨基芴-9-one的氟硼酸四唑盐的制备和溶剂化。还制备了盐酸替洛龙的非平面（1b），9-砜（1c）和芴（1d）类似物。评价化合物1b和1c的干扰素诱导。
• METHODS OF MAKING OLIGOPOTENT AND UNIPOTENT PRECURSORS
  申请人：Transfusion Health, LLC

  公开号：US20220315895A1

  公开（公告）日：2022-10-06

  This disclosure is directed to, inter alia, methods and systems for preparing oligopotent and unipotent progenitor cells of defined lineages in culture from an expanded source of CD34+ cells, media for making the same, and therapeutic compounds and compositions comprising the same for treatment a variety of diseases included, but not limited to, hematologic disorders, immune diseases, cancers, and infectious diseases.

  本公开涉及的是从扩增的CD34+细胞来源中在培养中准备定义谱系的寡能和单能祖细胞的方法和系统，用于制备相应的培养基，以及包含相应的治疗化合物和组合物，用于治疗各种疾病，包括但不限于血液学疾病、免疫性疾病、癌症和传染性疾病。
• Burke,S.M.; Joullie,M.M., Synthetic Communications, 1976, vol. 6, p. 371 - 376
  作者：Burke,S.M.、Joullie,M.M.

  DOI：——

  日期：——
• A Side-Chain Dendronized Nonlinear Optical Polyimide with Large and Thermally Stable Electrooptic Activity
  作者：Jingdong Luo、Marnie Haller、Hongxiang Li、Hong-Zhi Tang、Alex K.-Y. Jen、Kavitha Jakka、Chia-Hung Chou、Ching-Fong Shu

  DOI：10.1021/ma0350009

  日期：2004.1.1