N-(3-(benzo[d]thiazol-2-yl)-4-hydroxyphenyl)benzamide | 2533-14-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-(benzo[d]thiazol-2-yl)-4-hydroxyphenyl)benzamide
• 英文别名: N-(3-benzothiazol-2-yl-4-hydroxy-phenyl)-benzamide；Cambridge id 5756873；N-[3-(1,3-benzothiazol-2-yl)-4-hydroxyphenyl]benzamide
• CAS: 2533-14-4
• 化学式: C₂₀H₁₄N₂O₂S
• mdl: MFCD01144168
• 分子量: 346.409
• InChiKey: MTSBQELQHVXFMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  90.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(3-(benzo[d]thiazol-2-yl)-4-hydroxyphenyl)benzamide 在 碘代三甲硅烷 、 potassium tert-butylate 、 N,O-双(三甲基硅烷基)三氟乙酰胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 5.5h， 生成 4-benzamio-2-(benzo[d]thiazol-2-yl)phenyl dihydrogen phosphate
  参考文献：
  名称：

  A ratiometric fluorescent probe for alkaline phosphatase with high sensitivity

  摘要：

  Alkaline phosphatase (ALP) is one of essential biomarkers in mammalian tissue. Here we report a ratiometric probe for ALP, which is rationally designed and synthesized by employing ESIPT fluorophore N-(3-(benzo[d]thiazol-2-yl)-4-hydroxyphenyl)benzamide (BTHPB). The enzymatic dephosphorylation converts the probe to BTHPB, which exhibits a large spectral red-shift (120 nm), allowing extremely high sensitivity of ALP sensing at 0.004 mU/mL. The probe also shows excellent biocompatibility and has been applied for monitoring the endogenic ALP in living cells. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.cclet.2019.04.037
• 作为产物：
  描述：

  5-氨基水杨酸 在 吡啶 、 三氯化磷 作用下， 以 甲苯 为溶剂， 反应 4.25h， 生成 N-(3-(benzo[d]thiazol-2-yl)-4-hydroxyphenyl)benzamide
  参考文献：
  名称：

  Anthony, Kevin; Brown, Robert G.; Hepworth, John D., Journal of the Chemical Society. Perkin transactions II, 1984, p. 2111 - 2118

  摘要：

  DOI：

文献信息

• A Rapid Aqueous Fluoride Ion Sensor with Dual Output Modes
  作者：Rui Hu、Jiao Feng、Dehui Hu、Shuangqing Wang、Shayu Li、Yi Li、Guoqiang Yang

  DOI：10.1002/anie.201000790

  日期：——

  The color purple: A siloxy‐functionalized benzamide (see picture) is a highly efficient fluoride ion sensor in water. The sensor, which is activated when the OSi bond is cleaved by fluoride ions, provides two independent modes for signal recognition. In colorimetric mode, the fluoride ion concentration is transformed into a fluorescence signal that can be observed directly with the naked eye.

  紫色：硅烷氧基官能化的苯甲酰胺（见图）是水中的高效氟离子传感器。当OSi键被氟离子裂解时激活的传感器提供了两种独立的信号识别模式。在比色模式下，氟离子浓度转换为荧光信号，可以用肉眼直接观察到。
• AUTHENTICATABLE ARTICLES AND METHODS THEREFOR
  申请人：Chauhan Yogendrasinh Bharatsinh

  公开号：US20080081210A1

  公开（公告）日：2008-04-03

  An article comprising the compound of Formula (I): wherein R 1 is selected from the group consisting of an aliphatic functionality having 1 to 12 carbons, an aromatic functionality having 3 to 20 carbons, and a cycloaliphatic functionality having 3 to 20 carbons; R 2 and R 3 are independently selected from the group consisting of a hydroxyl group, a halogen atom, an aliphatic functionality having 1 to 12 carbons, an aromatic functionality having 3 to 20 carbons, and a cycloaliphatic functionality having 3 to 20 carbons; Y is either an oxygen atom or a sulfur atom; “n” has a value of 0 to 4; and “m” has a value of 0 to 3.

  本文涉及一种化合物，其化学式为（I）：其中R1选自具有1到12个碳的脂肪基、具有3到20个碳的芳香基和具有3到20个碳的环烷基的群组之一；R2和R3独立地选自具有1到12个碳的脂肪基、具有3到20个碳的芳香基和具有3到20个碳的环烷基的群组之一，以及羟基、卤素原子；Y是氧原子或硫原子；“n”的值为0到4；“m”的值为0到3。
• A “Reactive” Ratiometric Fluorescent Probe for Mercury Species
  作者：Mithun Santra、Basab Roy、Kyo Han Ahn

  DOI：10.1021/ol2011693

  日期：2011.7.1

  A ratiometric fluorescent probe for mercury species is developed bused on the metal-promoted hydrolysis of a vinyl ether derivative of 2-(benzothiazol-2-yl)phenol in a buffer solution. The probe responds selectively to mercury species over various other metal ions with a marked fluorescence change from blue to cyan through the excited state intramolecular proton transfer (ESIPT) process. The fluorescence titration is complete with 0.5 equiv of HgCl2, which indicates that the probe also responds to organomercury species, RHgCl.
• EP1162936A4
  申请人：——

  公开号：EP1162936A4

  公开（公告）日：2006-01-04
• BODY COATING COMPOSITION
  申请人：Pyramid Productions Inc.

  公开号：EP1162936A1

  公开（公告）日：2001-12-19