H-Asn-Phe-OH | 22849-01-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Asn-Phe-OH
• 英文别名: Asp-Phe；NF；Asn-Phe；L-Asparaginyl-L-phenylalanine；(2S)-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]-3-phenylpropanoic acid
• CAS: 22849-01-0
• 化学式: C₁₃H₁₇N₃O₄
• 分子量: 279.296
• InChiKey: OMSMPWHEGLNQOD-UWVGGRQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  H-Asn-Phe-OH 在 mercury(II) diacetate 、 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 半胱氨酰-赖氨酰-天冬氨酰胺酰-苯丙氨酸
  参考文献：
  名称：

  Pavo; Penke; Varga, Acta Chimica Hungarica, 1986, vol. 122, # 3-4, p. 261 - 272

  摘要：

  DOI：
• 作为产物：
  描述：

  3-苯基-L-丙氨酸苄酯 在 钯 氢气 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 H-Asn-Phe-OH
  参考文献：
  名称：

  一些二肽的结构-味道关系。

  摘要：

  DOI：

  10.1021/ja01038a046

文献信息

• Carbonic anhydrase activators for enhancig learning and memory
  申请人：Blanchette Rockefeller Neurosciences Institute

  公开号：EP1935414A2

  公开（公告）日：2008-06-25

  The invention provides activator compounds for improving attentive cognition comprising administering a compound that potentiates intraneuronal carbonic anhydrase activity thereby improving establishment of a theta rhythm.

  本发明提供了用于改善注意力认知的激活剂化合物，包括施用一种能增强神经元内碳酸酐酶活性的化合物，从而改善θ节律的建立。
• Carbonic anhydrase activator for enhancing learning and memory
  申请人：——

  公开号：US20040235889A1

  公开（公告）日：2004-11-25

  The invention provides a method for improving attentive cognition comprising administering a compound that potentiates intraneuronal carbonic anhydrase activity thereby improving establishment of a theta rhythm.

  本发明提供了一种改善注意力认知的方法，包括施用一种能增强神经元内碳酸酐酶活性的化合物，从而改善θ节律的建立。
• Catalytic Hydrolysis of Peptides by Cerium(IV)
  作者：Tohru Takarada、Morio Yashiro、Makoto Komiyama

  DOI：10.1002/1521-3765(20001103)6:21<3906::aid-chem3906>3.3.co;2-a

  日期：2000.11.3

  Oligopeptides are efficiently hydrolyzed by Ce-IV to the corresponding amino acids under mild conditions. The pseudo first-order rate constants for the hydrolysis of H-Gly-Phe-OH and H-Gly-Gly-OH at pH 7.0 and 50 degreesC are 3.5 x 10(-1) and 2.8 x 10(-1) h(-1), with [Ce(NH4)(2)(NO3)(6)](0) 10mM (the half-lives are 2.0 and 2.5 h). The catalytic activity of the Ce-IV is far greater than those of other lanthanide ions and non-lanthanide ions. No oxidative cleavage was observed under the reaction conditions. Catalytic turnover of the Ce-IV was also evidenced. The hydrolysis is fast especially when the substrates have no metal-coordinating side chains. Tripeptides and tetrapeptides are hydrolyzed at the similar rates as the dipeptides. In the hydrolysis of tripeptides, the amide linkage near the N-terminus is preferentially hydrolyzed. Neither the N-carbobenzploxy derivative nor the amide of H-Gly-Phe-OH is hydrolyzed to a measurable extent, showing that both the terminal amino group and the carboxylate are coordinated to the Ce-IV ion. This complexation is further confirmed by H-1 NR-IR spectroscopy. The Ce-IV ion is therefore one of the most active catalysts for peptide hydrolysis.
• Method for reductive elimination of protecting groups and preparative process using such method
  申请人：AJINOMOTO CO., INC.

  公开号：EP0027319B1

  公开（公告）日：1982-08-11
• EP1383497A4
  申请人：——

  公开号：EP1383497A4

  公开（公告）日：2005-12-14