tetra(2-pentachloro-phenoxycarbonyl-ethoxymethyl)methane | 183370-86-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tetra(2-pentachloro-phenoxycarbonyl-ethoxymethyl)methane
• 英文别名: (2,3,4,5,6-Pentachlorophenyl) 3-[3-[3-oxo-3-(2,3,4,5,6-pentachlorophenoxy)propoxy]-2,2-bis[[3-oxo-3-(2,3,4,5,6-pentachlorophenoxy)propoxy]methyl]propoxy]propanoate
• CAS: 183370-86-7
• 化学式: C₄₁H₂₄Cl₂₀O₁₂
• 分子量: 1417.69
• InChiKey: HUELFHNRAOMLCL-UHFFFAOYSA-N

物化性质

• 沸点：
  1100.1±65.0 °C(Predicted)
• 密度：
  1.696±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  17.8
• 重原子数：
  73
• 可旋转键数：
  28
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  142
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  tetra(2-pentachloro-phenoxycarbonyl-ethoxymethyl)methane 在 N-羟基丁二酰亚胺 、 三乙胺 作用下， 以 氯仿 为溶剂， 生成 N-Hydroxy-N-methyl-3-[3-(2-octadecylcarbamoyl-ethoxy)-2,2-bis-(2-octadecylcarbamoyl-ethoxymethyl)-propoxy]-propionamide
  参考文献：
  名称：

  Moav, Tamar; Hatzor, Anat; Cohen, Hagai, Chemistry - A European Journal, 1998, vol. 4, # 3, p. 502 - 507

  摘要：

  DOI：
• 作为产物：
  描述：

  季戊四醇 在 盐酸 、 sodium hydroxide 、 氯化亚砜 、 三乙胺 作用下， 以 氯仿 为溶剂， 反应 4.0h， 生成 tetra(2-pentachloro-phenoxycarbonyl-ethoxymethyl)methane
  参考文献：
  名称：

  荧光标记的铁色素类似物作为受体介导的微生物铁摄取探针

  摘要：

  微生物铁载体（铁载体）铁色素的仿生类似物 1 在不干扰铁结合或受体识别的位点用荧光标记物标记，以提供铁 (III) 载体 5 和 10（图 1）。这些载体由作为锚的四面体碳构建而成，该锚由三个会聚的铁结合链和一个单一的外源性蒽基残基对称延伸。载体 5 的氨基酸性质不同（G = 甘氨酰，A = 丙氨酰和 L = 亮氨酰）将锚与铁结合异羟肟酸基团连接起来，而丙氨酰衍生物 10A 与 5A 的不同之处在于蒽基标记和锚。通过 1 H NMR 检查这些结合剂证实它们的构象与未标记的母体化合物的构象相似。

  DOI：

  10.1021/ja9610646

文献信息

• Antibodies that inhibit metalloproteins
  申请人：Yeda Research and Development Co. Ltd.

  公开号：US09217041B2

  公开（公告）日：2015-12-22

  An antibody is disclosed which comprises an antigen recognition region which comprises six CDR amino acid sequences selected from the group consisting of SEQ ID NOs: 4-15. Uses thereof are also disclosed.

  披露了一种抗体，其中包括一个包含从序列标识号为4-15的群组中选择的六个CDR氨基酸序列的抗原识别区域。同时也披露了其用途。
• WO2008/102359
  申请人：——

  公开号：——

  公开（公告）日：——
• Modular Fluorescent-Labeled Siderophore Analogues
  作者：Raphael Nudelman、Orly Ardon、Yitzhak Hadar、Yona Chen、Jacqueline Libman、Abraham Shanzer

  DOI：10.1021/jm970581b

  日期：1998.5.1

  Biomimetic analogues 1 of the microbial siderophore (iron carrier) ferrichrome were labeled via piperazine with various fluorescent markers at a site not interfering with iron binding or receptor recognition (compounds 10-12). These iron carriers were built from a tetrahedral carbon symmetrically extended with three strands, each containing an amino acid (G = glycyl, A = alanyl, L = leucyl and P = phenylalanyl) and terminated by a hydroxamic acid, which together define an octahedral iron-binding domain. A fourth exogenous strand provided the site for connecting various fluorescent markers via a short bifunctional linker. Iron(III) titrations, along with fluorescence spectroscopy, generated quenching of fluorescence emission of some of the probes used. The quenching process fits the Perrin model which reinforces the intramolecular quenching process, postulated previously.(1) All tested compounds, regardless of their probe size, polarity, or the linker binding them to the siderophore analogue, promote growth of Pseudomonas putida with the same efficacy as the nonlabeled analogues 1, with the added benefit of signaling microbial activity by fluorescence emission. All G derivatives of compounds 10-12 were found to parallel the behavior of natural ferrichrome, whereas A derivatives mediated only a modest iron(III) uptake by P. putida. Incubation of various Pseudomonas strains with iron(III)-loaded G derivatives resulted in the build-up of the labels' fluorescence in the culture medium to a much larger extent than from the corresponding A derivatives. The fluorescence buildup corresponds to iron utilization by the cells and the release of the fluorescent labeled desferrisiderophore from the cell to the media. The fact that the microbial activity of these compounds is not altered by attachment of various fluorescent markers via a bifunctional linker proposes their application as diagnostic tools for detecting and identifying pathogenic microorganisms.
• ANTIBODIES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME USEFUL FOR INHIBITING ACTIVITY OF METALLOPROTEINS
  申请人：Yeda Research And Development Co. Ltd.

  公开号：EP2155691A1

  公开（公告）日：2010-02-24
• ANTIBODIES AND PHARAMCETICAL COMPOSITIONS CONTAINING SAME USEFUL FOR INHIBITING ACTIVITY OF METALLOPROTEINS
  申请人：Sagi Irit

  公开号：US20100233188A1

  公开（公告）日：2010-09-16

  The present invention relates to a compound having the general Formula (I): wherein: m and n are each independently an integer from 1 to 6; X 1 -X 3 and Y 1 -Y 3 are each independently O or S; R 1 -R 3 are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl; and R is (CH 2 )x—C(═O)NR′—(CH 2 )y—NR′R″ whereas: x and y are each independently an integer from 1 to 6; and R′ and R″ are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl; and to an antibody comprising an antigen recognition region capable of specifically binding the above compound.