Butane, 1,1'-oxybis[2-chloro- | 21835-61-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Butane, 1,1'-oxybis[2-chloro-
• 英文别名: 2-chloro-1-(2-chlorobutoxy)butane
• CAS: 21835-61-0
• 化学式: C₈H₁₆Cl₂O
• 分子量: 199.11
• InChiKey: PKUIMEDORBCCTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF<br/>[FR] COMPOSÉS COMPRENANT UN LIEUR CLIVABLE ET LEURS UTILISATIONS
  申请人：INTOCELL INC

  公开号：WO2019008441A1

  公开（公告）日：2019-01-10

  Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a SO2 functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.

  提供了一种包括可切割连接物的化合物，其用途，以及用于制备该化合物的中间体化合物，更具体地，本发明的包括可切割连接物的化合物可能包括具有特定功能或活性的活性剂（例如，药物，毒素，配体，用于检测的探针等），能够选择性释放活性剂的SO2官能团，以及通过外部刺激触发化学反应，物理化学反应和/或生物反应的官能团，并且还可以包括具有与所需靶受体结合特异性的配体（例如，寡肽，多肽，抗体等）。
• METHOD FOR PREPARATION OF ARYL POLY(OXALKYL) QUATERNARY AMMONIUM COMPOUND
  申请人：Cheng Che Jim

  公开号：US20140187819A1

  公开（公告）日：2014-07-03

  A method for preparation of an aryl poly(oxalkyl) quaternary ammonium compound is provided, said method comprising steps of: 1) reacting a phenol with a dihalopolyalkylene ether under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) halide; 2) reacting said arylpoly(oxalkyl) halide with an amination reagent under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) amine; 3) reacting said arylpoly(oxalkyl) amine with an alkylation reagent, to obtain an aryl poly(oxalkyl) quaternary ammonium compound; wherein R 1 is H or a C 1 to C 16 alkyl group, located in the ortho, meta or para position; n is an integer of 2 to 6; R 2 is H or a C 1 to C 16 alkyl group; R 3 is H or a C 1 to C 16 alkyl group; R 4 is a C 1 to C 16 alkyl group; X 1 is Br or Cl; X is Cl, Br, or I. The preparation method according to the present invention requires low temperature and low pressure, the reaction time is short, and an overall yield can reach 75%. The operation is simple, the cost is low, and the product can be separated easily and have a purity of pharmaceutical grade, thereby facilitating the large-scale production.

  提供一种制备芳基聚（氧烷基）季铵化合物的方法，该方法包括以下步骤：1）在相转移催化剂的作用下，将酚与二卤代聚烯醚反应，得到芳基聚（氧烷基）卤化物；2）在相转移催化剂的作用下，将所述芳基聚（氧烷基）卤化物与胺化试剂反应，得到芳基聚（氧烷基）胺；3）将所述芳基聚（氧烷基）胺与烷基化试剂反应，得到芳基聚（氧烷基）季铵化合物；其中R1为H或C1至C16烷基，位于邻位、间位或对位；n为2至6的整数；R2为H或C1至C16烷基；R3为H或C1至C16烷基；R4为C1至C16烷基；X1为Br或Cl；X为Cl、Br或I。根据本发明的制备方法需要低温低压，反应时间短，总产率可达75%。操作简单，成本低，产品易于分离，具有药品级纯度，有利于大规模生产。
• METHOD FOR PREPARING ARYL POLYOXY ALKYL QUATERNARY AMMONIUM COMPOUND
  申请人：Beijing Sunpu Biochem. Tech. Co., Ltd.

  公开号：EP2703382A1

  公开（公告）日：2014-03-05

  A method for preparation of an aryl poly(oxalkyl) quaternary ammonium compound is provided, said method comprising steps of: 1) reacting a phenol with a dihalopolyalkylene ether under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) halide; 2) reacting said arylpoly(oxalkyl) halide with an amination reagent under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) amine; 3) reacting said arylpoly(oxalkyl) amine with an alkylation reagent, to obtain an aryl poly(oxalkyl) quaternary ammonium compound; wherein R1 is H or a C1 to C16 alkyl group, located in the ortho, meta or para position; n is an integer of 2 to 6; R2 is H or a C1 to C16 alkyl group; R3 is H or a C1 to C16 alkyl group; R4 is a C1 to C16 alkyl group; X1 is Br or Cl; X is Cl, Br, or I. The preparation method according to the present invention requires low temperature and low pressure, the reaction time is short, and an overall yield can reach 75%. The operation is simple, the cost is low, and the product can be separated easily and have a purity of pharmaceutical grade, thereby facilitating the large-scale production.

  本发明提供了一种制备芳基聚（氧烷基）季铵化合物的方法，所述方法包括以下步骤：1) 在相转移催化剂的作用下，使苯酚与二卤代聚烷基醚反应，得到芳基聚（氧烷基）卤化物； 2) 在相转移催化剂的作用下，使所述芳基聚（氧烷基）卤化物与胺化试剂反应，得到芳基聚（氧烷基）胺；3) 将所述芳基聚(氧烷基)胺与烷基化试剂反应，得到芳基聚(氧烷基)季铵盐化合物； 其中 R1 是 H 或位于正、偏或对位的 C1 至 C16 烷基；n 是 2 至 6 的整数；R2 是 H 或 C1 至 C16 烷基；R3 是 H 或 C1 至 C16 烷基；R4 是 C1 至 C16 烷基；X1 是 Br 或 Cl；X 是 Cl、Br 或 I。本发明的制备方法需要低温低压，反应时间短，总收率可达 75%。操作简单，成本低，产品易于分离，纯度达到医药级，便于大规模生产。
• Benzodiazepine derivatives and uses thereof
  申请人：IntoCell, Inc.

  公开号：US11084801B2

  公开（公告）日：2021-08-10

  The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

  本公开提供了能够延长寿命的化合物和组合物及其使用方法。
• COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF
  申请人：Intocell, Inc.

  公开号：EP3649142A1

  公开（公告）日：2020-05-13