N-(4-methylphenyl)-L-alanine | 693803-84-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(4-methylphenyl)-L-alanine
• 英文别名: 4-Methylphenyl-L-alanine；(2S)-2-(4-methylanilino)propanoic acid
• CAS: 693803-84-8
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: KZUIVFOYFVOBAR-QMMMGPOBSA-N

物化性质

• 熔点：
  142 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
• 沸点：
  359.7±25.0 °C(Predicted)
• 密度：
  1.169±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(4-methylphenyl)-L-alanine 、 2-溴苯乙酮 在 三乙胺 作用下， 以 乙酸乙酯 为溶剂， 生成 2-oxo-2-phenylethyl (S)-2-(p-tolylamino)propanoate
  参考文献：
  名称：

  通过两个CuI催化的交叉偶联反应合成1，5-苯并噻氮杂二肽模拟物

  摘要：

  CuI催化的4-甲基苯基溴化物与氨基酸的偶合生成N-芳基氨基酸，其通过碘化和与1-半胱氨酸衍生的酰氯缩合而转化为线性二肽。通过CuI / N，N，N-二甲基甘氨酸催化的芳基碘化物与释放的硫醇的分子内偶联来实现环化，从而提供1，5-苯并噻氮杂二肽模拟物。

  DOI：

  10.1021/ol900943b
• 作为产物：
  描述：

  L-丙氨酸 、 对溴甲苯 在 copper(l) iodide 、 2-(2-甲基-1-氧代丙烷)环己酮 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 14.0h， 以81%的产率得到N-(4-methylphenyl)-L-alanine
  参考文献：
  名称：

  使用铜（i）和β-二酮对氨基酸和肽进行室温N-芳基化†

  摘要：

  描述了一种用于两性离子氨基酸，氨基酸酯和肽的N-芳基化的温和且有效的方法。该方法提供了第一个室温下使用CuI作为催化剂，二酮作为配体，芳基碘化物作为偶联伴侣的N-芳基化氨基酸和多肽的室温合成方法。该方法同样适用于在80°C下使用相对便宜的芳基溴化物作为偶联伙伴。使用该程序，可以有效地以良好至优异的产率偶联含有反应性官能团的电子和空间上不同的芳基卤化物。

  DOI：

  10.1039/c5ob00288e

文献信息

• [EN] MACROCYCLIC PEPTIDES USEFUL AS IMMUNOMODULATORS<br/>[FR] PEPTIDES MACROCYCLIQUES UTILES COMME IMMUNOMOLDULATEURS
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2016077518A1

  公开（公告）日：2016-05-19

  The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

  本公开提供了一些免疫调节剂化合物，因此对于改善各种疾病，包括癌症和传染病，具有用处。
• Racemic Drug Resolution Using Polymer Supported Chiral Selector
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEAECH

  公开号：US20160208088A1

  公开（公告）日：2016-07-21

  The present invention relates to a process for the separation of enantiomers or resolution of racemic mixtures using high surface area core-shell polymer beads. The present invention further relates to a core-shell functionalized polymer comprising a core which comprises copolymer made from monomers selected from non-aromatic acrylate, ethylene dimethacrylate and divinyl-benzene, a shell which comprises monomers selected from glycidyl ethers of methacrylate and a chiral selector selected from tartaric acid derivatives and amino acids.

  本发明涉及使用高表面积核壳聚合物珠子分离对映体或分离混合物的过程。本发明还涉及一种核壳功能化聚合物，包括一个核，该核由从非芳香族丙烯酸酯、乙二醇二甲基丙烯酸酯和二乙烯基苯中选择的单体共聚而成，一个壳，该壳由从甲基丙烯酸醋酸酯的环氧乙醚和酒石酸衍生物和氨基酸中选择的单体组成的手性选择剂。
• Method for producing tropane alkaloid
  申请人：SEITAIKINOU RIYOU KAGAKUHIN SHINSEIZOUGIJUTSU KENKYU KUMIAI

  公开号：EP0331404A2

  公开（公告）日：1989-09-06

  Methods for producing tropane alkaloids, such as scopolamine and/or hyoscyamine, by the tissue culture of tissues or cells of plants; tropane alkaloid-hyperproducing cells suitable for the production of tropane alkaloids, and a method for obtaining such cells; and a method for separating and purifying a tropane alkaloid from tropane alkaloid-containing cells are disclosed.

  本发明公开了通过植物组织或细胞的组织培养生产东莨菪碱和/或玻尿酸等滋补生物碱的方法；适用于生产滋补生物碱的滋补生物碱高产细胞和获得这种细胞的方法；以及从含有滋补生物碱的细胞中分离和纯化滋补生物碱的方法。
• Sustained-release preparation
  申请人：——

  公开号：US20020058622A1

  公开（公告）日：2002-05-16

  According to a first embodiment, there is provided a sustained-release preparation comprising a water-insoluble or slightly water-soluble polyvalent metal salt of a water-soluble physiologically active substance which is not an endothelin antagonist, and a biodegradable polymer. The sustained-release preparation of the first embodiment is highly efficient in incorporating the water-soluble physiologically active substance and suppresses the initial burst of the water-soluble physiologically active substance. The sustained-release preparation of the present invention is capable of releasing the water-soluble physiologically active substance while retaining its bioactivity after administration in vivo. Furthermore, the water-soluble physiologically active substance in the sustained-release preparation is kept stable for a long period of time, with little loss of bioactivity. According to a second embodiment, there is provided a sustained-release preparation comprising an anti-endothelin substance and a biodegradable polymer. The sustained-release preparation of the present invention sustainedly releases an anti-endothelin substance, serving well in the treatment of endothelin-associated diseases.

  根据第一个实施方案，提供了一种缓释制剂，该制剂包含一种不溶于水或微溶于水的水溶性生理活性物质的多价金属盐，该生理活性物质不是内皮素拮抗剂，还包含一种可生物降解的聚合物。第一实施方案中的缓释制剂能高效地掺入水溶性生理活性物质，并抑制水溶性生理活性物质的初始迸发。本发明的缓释制剂能够释放水溶性生理活性物质，同时在体内给药后保持其生物活性。此外，本发明的缓释制剂中的水溶性生理活性物质可保持长期稳定，生物活性损失小。 根据第二个实施方案，本发明提供了一种由抗内皮素物质和生物可降解聚合物组成的缓释制剂。本发明的缓释制剂可持续释放抗内皮素物质，在治疗内皮素相关疾病中发挥良好作用。
• Non-toxic corrosion-protection pigments based on manganese
  申请人：——

  公开号：US20040011252A1

  公开（公告）日：2004-01-22

  Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

  以锰为基础的缓蚀颜料含有三价或四价锰/价稳定剂复合物。一种无机或有机材料可用于稳定三价或四价锰离子，从而形成一种可少量溶解、溶解度低或不溶于水的化合物，具体取决于预期用途。选择特定的稳定剂是为了控制三价锰或四价锰在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。锰/价稳定剂组合的选择是基于锰配位化学的基本原理。文中介绍了许多锰价稳定剂组合，其性能与传统的六价铬或四价铅体系相当。需要强调的是，提供本摘要是为了符合要求提供摘要的规则，以便检索者或其他读者快速确定技术公开的主题。提交本摘要的前提是，本摘要不用于解释或限制权利要求的范围或含义。