sorbitol phosphate | 67670-70-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: sorbitol phosphate
• 英文别名: D-Glucitmonophosphat；d-Glucitol, phosphate；[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl] dihydrogen phosphate
• CAS: 67670-70-6
• 化学式: C₆H₁₅O₉P
• 分子量: 262.153
• InChiKey: GACTWZZMVMUKNG-JGWLITMVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.7
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  168
• 氢给体数：
  7
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  山梨醇 在 disodium pyrophoshate 、 acid phosphatase from Shigella flexneri (class A₁ enzyme) 作用下， 以 acetate buffer 为溶剂， 生成 山梨糖醇 6-磷酸酯 、 sorbitol phosphate
  参考文献：
  名称：

  细菌磷酸酶对碳水化合物和多种醇进行区域选择性磷酸化；探索弗氏志贺氏菌酶的底物特异性

  摘要：

  细菌非特异性酸性磷酸酶通常催化多种底物的去磷酸化。如前所述，来自弗氏志贺氏菌和肠炎沙门氏菌的酶也能够使用廉价的焦磷酸盐作为磷酸盐供体，催化将肌苷磷酸化为肌苷单磷酸和将D-葡萄糖磷酸化为D-葡萄糖6-磷酸（D-G6P）。经过优化后，在后一反应中可实现高收率（95％），我们在此表明​​可以以制备方式使用这些酶。这促使我们使用31P NMR和HPLC还可以使多种碳水化合物和醇类进行磷酸化。许多环状碳水化合物以区域选择性方式被磷酸化。非环状碳水化合物也被磷酸化。直链醇，环状和芳族醇的磷酸化也是可能的。在所有情况下，志贺氏菌的酸性磷酸酶都比伯醇更喜欢伯醇功能。我们得出结论，在广泛范围的化合物磷酸化中，这些酶是现有化学和酶促方法的一种有吸引力的替代物。

  DOI：

  10.1002/adsc.200505072

文献信息

• Mammalian promotors useful in yeast expression
  申请人：CETUS CORPORATION

  公开号：EP0165759A2

  公开（公告）日：1985-12-27

  Expression vectors containing coding sequences under the control of mammalian promoters are disclosed as useful in producing proteins in yeasts. Construction of such vectors, and their use in yeast transformations are described.

  本发明公开了含有哺乳动物启动子控制下的编码序列的表达载体，用于在酵母中生产蛋白质。 本发明描述了此类载体的构建及其在酵母转化中的应用。
• Novel phosphobetaine and detergent and cosmetic containing the same
  申请人：Kao Corporation

  公开号：EP0514588A2

  公开（公告）日：1992-11-25

  A novel phosphobetaine is disclosed. This compound is very excellence in that it exerts a conditioning effect of imparting a good feel to the skin or hair, is excellent in humidifying properties, is available at a low price, and thus it is highly usable in detergents, cosmetics, a bathing preparation and the like. A detergent composition, a cosmetic, and a bathing preparation each containing the phosphobetaine are also disclosed.

  本研究公开了一种新型磷脂酰基化合物。这种化合物非常出色，它具有调理作用，能给皮肤或头发带来良好的触感，具有极佳的加湿性能，而且价格低廉，因此在洗涤剂、化妆品、沐浴剂等方面具有很高的实用性。此外，还公开了一种洗涤剂组合物、一种化妆品和一种沐浴剂，它们都含有磷脂质。
• Nutrient-supplying preparation
  申请人：THE GREEN CROSS CORPORATION

  公开号：EP0671166A2

  公开（公告）日：1995-09-13

  Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes. An infusion preparation containing a sugar, amino acids, electrolytes and a fat emulsion can be obtained easily and aseptically upon use, by simply removing a separation means attached to the container and mixing the two infusion liquids.

  本发明公开了一种用于营养供应的输液制剂。它由糖、氨基酸、电解质和脂肪乳液组成。尽管这些成分同时存在，但它具有极佳的保质期，不会引起沉淀、变性等现象。本发明还公开了一种装有输液的容器，该容器包括通过分离装置相互隔开的第一和第二隔室，其中第一隔室中装有一种含有脂肪乳液和糖的输液，第二隔室中装有另一种含有氨基酸和电解质的输液。进一步公开了一种包含脂肪乳液和糖的输液制剂，以及一种包含氨基酸和电解质的输液制剂。使用时，只需取下附在容器上的分离装置，将两种输液混合，即可方便无菌地获得含有糖、氨基酸、电解质和脂肪乳液的输液制剂。
• NUTRITIONAL TRANSFUSION FOR PERIPHERAL VEIN ADMINISTRATION
  申请人：THE GREEN CROSS CORPORATION

  公开号：EP0700681A1

  公开（公告）日：1996-03-13

  A nutritional transfusion that can be administered via peripheral veins and is improved in stability and conservability. It contains a saccharide, an amino acid, an electrolyte and a fat emulsion each in a specified proportion and has specified pH value and titratable acidity. It has a good conservability because it is free from precipitation and denaturation in spite of its composition comprising the above various components. Further it is free from the problem of angialgia or the like even when administered via peripheral veins, since it has a specified pH value and a low titratable acidity.

  一种可通过外周静脉输注的营养输液，其稳定性和保存性均有所提高。它包含一种糖、一种氨基酸、一种电解质和一种脂肪乳液，每种物质都有规定的比例，并有规定的 pH 值和可滴定酸度。它具有良好的保存性，因为尽管其成分包括上述各种成分，但它不会发生沉淀和变性。此外，由于它具有特定的 pH 值和较低的可滴定酸度，因此即使通过外周静脉给药，也不会出现血管痛等问题。
• TRANSFUSION CONTAINER, TRANSFUSION PREPARATION, AND COMPREHENSIVE VITAMIN-CONTAINING HIGH-CALORIE TRANSFUSION PREPARATION
  申请人：THE GREEN CROSS CORPORATION

  公开号：EP0704199A1

  公开（公告）日：1996-04-03

  A transfusion container useful for preparing a transfusion containing saccharide, amino acid, electrolyte, fat emulsion and vitamin. The container is composed of two compartments with a partitioning means provided therebetween, and a first compartment contains a transfusion containing fat emulsion, saccharide and specified vitamin, while a second compartment contains a transfusion containing amino acid, electrolyte and other specified vitamin. A transfusion preparation containing saccharide, amino acid, electrolyte, fat emulsion and vitamin can be readily and aseptically prepared by removing the partitioning means prior to use and mixing the transfusions contained in the two compartments together.

  一种输液容器，用于配制含有糖、氨基酸、电解质、脂肪乳液和维生素的输液。该容器由两个隔室组成，隔室之间设有分隔装置，第一隔室装有含脂肪乳剂、糖和特定维生素的输液，第二隔室装有含氨基酸、电解质和其他特定维生素的输液。在使用前移除分隔装置并将两个隔室中的输液混合在一起，就可以方便无菌地制备含有糖、氨基酸、电解质、脂肪乳液和维生素的输液制剂。