turtschamide | 1367102-83-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: turtschamide
• 英文别名: 4-hydroxy-N-[(3S,5R)-3-[(4-hydroxyphenyl)methyl]-2-oxo-1,4-diazocan-5-yl]benzamide
• CAS: 1367102-83-7
• 化学式: C₂₀H₂₃N₃O₄
• 分子量: 369.42
• InChiKey: ZKWVAKMBYOHWJH-ZWKOTPCHSA-N

物化性质

• 沸点：
  723.7±60.0 °C(Predicted)
• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  111
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  turtschamide 、 N-A-(2,4-二硝基-5-氟苯基)-L-丙氨酸 在 sodium cyanoborohydride 、 溶剂黄146 、 盐酸 、 水 、 碳酸氢钠 作用下， 以 乙腈 、 水 、 丙酮 为溶剂， 反应 28.0h， 生成 DAA-L-Tyr-OH
  参考文献：
  名称：

  Turtschamide, a cytotoxic putrescine bisamide from Corydalis turtschaninovii

  摘要：

  A putrescine bisamide with a unique cyclic structure derived from L-tyrosine, turtschamide (1), was isolated from the tubers of Corydalis turtschaninovii. The structure of 1 was established by extensive spectroscopic study, and its absolute configuration was determined by a combination of NOE experiment and application of the Marfey's method. Turtschamide (1) exhibited cytotoxicity against the A549, SK-OV-3, SK-MEL-2, and HCT-15 cells. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.01.043

文献信息

• Turtschamide, a cytotoxic putrescine bisamide from Corydalis turtschaninovii
  作者：Ki Hyun Kim、Sang Un Choi、Kang Ro Lee

  DOI：10.1016/j.tetlet.2012.01.043

  日期：2012.3

  A putrescine bisamide with a unique cyclic structure derived from L-tyrosine, turtschamide (1), was isolated from the tubers of Corydalis turtschaninovii. The structure of 1 was established by extensive spectroscopic study, and its absolute configuration was determined by a combination of NOE experiment and application of the Marfey's method. Turtschamide (1) exhibited cytotoxicity against the A549, SK-OV-3, SK-MEL-2, and HCT-15 cells. (C) 2012 Elsevier Ltd. All rights reserved.