4-chloro-3-carboxy-flav-3-ene | 99943-58-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 4-chloro-3-carboxy-flav-3-ene
• 英文别名: 4-chloro-2-phenyl-2H-chromene-3-carboxylic acid
• CAS: 99943-58-5
• 化学式: C₁₆H₁₁ClO₃
• 分子量: 286.715
• InChiKey: JMWXOMKRMBYZGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-chloro-2-phenyl-2H-chromene-3-carbaldehyde 、 sodium hypochlorite 生成 4-chloro-3-carboxy-flav-3-ene
  参考文献：
  名称：

  RIMBAULT, CH. G.;NARBEL, PH. M.

  摘要：

  DOI：

文献信息

• Flavene and thioflavene derivatives
  申请人：Zyma SA

  公开号：US04665202A1

  公开（公告）日：1987-05-12

  The invention relates to pharmaceutical preparations containing compounds of formula I ##STR1## in which X.sub.1 and X.sub.2, independently of each other, represent hydrogen, halogen, unsubstituted or substituted amino or a quaternary ammonium salt; etherified or esterified hydroxy; free, etherified, esterified or oxidized mercapto; nitro; functionally modified formyl; free or functionally modified carboxyl; acyl; an unsubstituted or substituted hydrocarbon radical, or an unsubstituted or substituted heterocyclic radical; with the proviso that at least one of the radicals X.sub.1 and X.sub.2 is bonded by a carbon atom to the ring system and with the proviso that X.sub.1 and X.sub.2 cannot be together halogen and formyl; in which Y represents oxygen, sulfur, sulfinyl or sulfonyl but must be sulfur, sulfinyl or sulfonyl, if X.sub.1 is hydrogen and X.sub.2 is formyl, and the rings A and B are each unsubstituted or substituted; or pharmaceutically acceptable salts of such compounds that contain a salt-forming group, and to novel compounds of formula I. The compounds are useful e.g. for the treatment of diseases of the respiratory tract and of liver diseases. The are prepared by methods known per se.

  本发明涉及含有式I的化合物的制药制剂：##STR1## 其中X.sub.1和X.sub.2独立地表示氢、卤素、未取代或取代的氨基或季铵盐；醚化或酯化的羟基；自由、醚化、酯化或氧化的巯基；硝基；功能修饰的甲酰基；自由或功能修饰的羧基；酰基；未取代或取代的烃基或未取代或取代的杂环基；但必须至少有一个基团X.sub.1和X.sub.2由碳原子与环系相连，并且必须满足X.sub.1和X.sub.2不能同时为卤素和甲酰基；其中Y表示氧、硫、亚砜或磺酰基，但如果X.sub.1为氢且X.sub.2为甲酰基，则必须为硫、亚砜或磺酰基，环A和B均未取代或取代；或者其药学上可接受的含有成盐基团的化合物的盐，以及式I的新化合物。这些化合物可用于治疗呼吸道疾病和肝病等疾病。它们是通过已知的方法制备的。
• Pharmaceutical preparations containing flavene or thioflavene derivatives, the use thereof, novel flavenes and thioflavenes, and processes for their manufacture
  申请人：Zyma SA

  公开号：EP0140830B1

  公开（公告）日：1989-08-30
• US4665202A
  申请人：——

  公开号：US4665202A

  公开（公告）日：1987-05-12
• RIMBAULT, CH. G.;NARBEL, PH. M.
  作者：RIMBAULT, CH. G.、NARBEL, PH. M.

  DOI：——

  日期：——