2,3-di(furan-2-yl)pyrazine | 87891-40-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,3-di(furan-2-yl)pyrazine
• 英文别名: 2,3-Bis(furan-2-yl)pyrazine；2,3-bis(furan-2-yl)pyrazine
• CAS: 87891-40-5
• 化学式: C₁₂H₈N₂O₂
• 分子量: 212.208
• InChiKey: SIYAVNPNIIMKOJ-UHFFFAOYSA-N

物化性质

• 熔点：
  81 °C(Solv: ethanol (64-17-5))
• 沸点：
  278.3±35.0 °C(Predicted)
• 密度：
  1.233±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙二胺 、 2,2'-联糠醛 在 silica sulfuric acid 、 PEG-400 作用下， 反应 6.0h， 以76%的产率得到2,3-di(furan-2-yl)pyrazine
  参考文献：
  名称：

  Silica Sulfuric Acid (SSA)/Polyethylene Glycol (PEG) as a Recyclable System for the Synthesis of Quinoxalines and Pyrazines

  摘要：

  An efficient and facile method has been developed for the condensation of 1,2-diamines with alpha-hydroxyketones in polyethylene glycol (PEG) to quinoxalines and pyrazines with good yields in the presence of silica sulfuric acid (SSA). The important features of the methodology are simple operations, environmentally friendliness, and no requirement for metal catalysts. Additionally, the catalyst system (SSA/PEG) could be recovered easily and reused.

  DOI：

  10.1080/00397911.2010.517894

文献信息

• Electrochemical oxidation synergizing with Brønsted-acid catalysis leads to [4 + 2] annulation for the synthesis of pyrazines
  作者：Kun Liu、Chunlan Song、Jiarong Wu、Yuqi Deng、Shan Tang、Aiwen Lei

  DOI：10.1039/c8gc03786h

  日期：——

  Electrochemical oxidative [4 + 2] annulation for the synthesis of pyrazines.

  电化学氧化[4 + 2]环化合成吡嗪。
• Catalyst-Free Protocol for the Synthesis of Quinoxalines and Pyrazines in PEG
  作者：Tie-Qiang Huang、Wen-Yan Qu、Jin-Chang Ding、Miao-Chang Liu、Hua-Yue Wu、Jiu-Xi Chen

  DOI：10.1002/jhet.1043

  日期：2013.3

  developed for the condensation of 1,2‐diketones with aromatic 1,2‐diamines in polyethylene glycol (PEG), providing quinoxaline derivatives in good yields. The important features of the methodology are broad substrates scope, simple workup, catalyst free, environmentally benign, and no requirement for metal catalysts. It is noteworthy that the cyclization reaction of 1,2‐diketones with aliphatic 1,2‐diamines

  已开发出一种简便且无催化剂的方案，用于将1,2-二酮与芳族1,2-二胺在聚乙二醇（PEG）中缩合，从而以高收率提供喹喔啉衍生物。该方法的重要特征是广泛的底物范围，简单的后处理，无催化剂，对环境无害，并且不需要金属催化剂。值得注意的是，在标准条件下，1,2-二酮与脂肪族1,2-二胺的环化反应也能顺利进行，从而以高收率获得吡嗪。此外，PEG可以轻松回收并重新使用，而活性没有明显损失
• N-heterocycles as corrosion inhibitors for mild steel in acid medium
  作者：Jagadeesan Saranya、Murugaiyan Sowmiya、Palanisamy Sounthari、Kandhasamy Parameswari、Subramanian Chitra、Kittusamy Senthilkumar

  DOI：10.1016/j.molliq.2015.12.096

  日期：2016.4

  showed that the three inhibitors possess excellent inhibition effect toward mild steel corrosion. The inhibitor molecules are adsorbed on the mild steel surface, blocking the reactive sites available for acid attack. Adsorption of the inhibitor was found to obey Langmuir isotherm. Electronic structure calculations were used to study the inhibition efficiency of the inhibitor molecules on Fe (100) surface

  低碳钢在1 MH 2 SO 4中的腐蚀行为使用2,3-二苯基吡嗪（DP），2,3-二（呋喃-2-基）吡嗪（FP）和2,3-二（呋喃-2-基）喹喔啉（FQ）作为抑制剂，研究了减肥方法，电位动力学极化和电化学阻抗谱（EIS）研究。扫描电子显微镜（SEM）和原子力显微镜（AFM）方法用于表面表征。结果表明，三种缓蚀剂对低碳钢腐蚀均具有优异的缓蚀作用。抑制剂分子吸附在低碳钢表面上，从而阻断了可用于酸侵蚀的反应位点。发现抑制剂的吸附遵守朗缪尔等温线。电子结构计算被用来研究抑制剂分子对Fe（100）表面的抑制效率。计算结果与实验结果相符。
• Silica Sulfuric Acid (SSA)/Polyethylene Glycol (PEG) as a Recyclable System for the Synthesis of Quinoxalines and Pyrazines
  作者：Tieqiang Huang、Danna Jiang、Jiuxi Chen、Wenxia Gao、Jinchang Ding、Huayue Wu

  DOI：10.1080/00397911.2010.517894

  日期：2011.11.15

  An efficient and facile method has been developed for the condensation of 1,2-diamines with alpha-hydroxyketones in polyethylene glycol (PEG) to quinoxalines and pyrazines with good yields in the presence of silica sulfuric acid (SSA). The important features of the methodology are simple operations, environmentally friendliness, and no requirement for metal catalysts. Additionally, the catalyst system (SSA/PEG) could be recovered easily and reused.