trimethylsilyl (Z)-7-[(1R,2R,3R,5S)-3,5-bis(trimethylsilyloxy)-2-[(E,3S)-3-trimethylsilyloxyoct-1-enyl]cyclopentyl]hept-5-enoate | 50669-95-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: trimethylsilyl (Z)-7-[(1R,2R,3R,5S)-3,5-bis(trimethylsilyloxy)-2-[(E,3S)-3-trimethylsilyloxyoct-1-enyl]cyclopentyl]hept-5-enoate
• CAS: 50669-95-9
• 化学式: C₃₂H₆₆O₅Si₄
• 分子量: 643.215
• InChiKey: ZWRMXRMPDPQJCB-SEARXOTLSA-N

物化性质

• 沸点：
  557.8±50.0 °C(Predicted)
• 密度：
  0.93±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.91
• 重原子数：
  41
• 可旋转键数：
  20
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  trimethylsilyl (Z)-7-[(1R,2R,3R,5S)-3,5-bis(trimethylsilyloxy)-2-[(E,3S)-3-trimethylsilyloxyoct-1-enyl]cyclopentyl]hept-5-enoate 在 N-(三甲基硅基)吗啉 、 三氟化硫吗啉 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Prostaglandin fluorides in synthesis of natural prostaglandin derivatives at carboxyl group

  摘要：

  Methods of synthesis of prostaglandin fluorides were developed and their properties were investigated. These compounds were shown to be convenient synthetic precursors for obtaining esters and amides of natural prostaglandins and their fluorodeoxy analogues.

  DOI：

  10.1134/s1068162009010142
• 作为产物：
  描述：

  三甲基氯硅烷 、 地诺前列素 、 六甲基二硅氮烷 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 trimethylsilyl (Z)-7-[(1R,2R,3R,5S)-3,5-bis(trimethylsilyloxy)-2-[(E,3S)-3-trimethylsilyloxyoct-1-enyl]cyclopentyl]hept-5-enoate
  参考文献：
  名称：

  Prostaglandin fluorides in synthesis of natural prostaglandin derivatives at carboxyl group

  摘要：

  Methods of synthesis of prostaglandin fluorides were developed and their properties were investigated. These compounds were shown to be convenient synthetic precursors for obtaining esters and amides of natural prostaglandins and their fluorodeoxy analogues.

  DOI：

  10.1134/s1068162009010142

文献信息

• CIUCANU, JONEL;POP, DORINA;TIMOCEANU, VIOREL, J. CHROMATOGR., 436,(1988) N 2, 219-228
  作者：CIUCANU, JONEL、POP, DORINA、TIMOCEANU, VIOREL

  DOI：——

  日期：——
• Prostaglandin fluorides in synthesis of natural prostaglandin derivatives at carboxyl group
  作者：I. V. Serkov、V. V. Bezuglov

  DOI：10.1134/s1068162009010142

  日期：2009.1

  Methods of synthesis of prostaglandin fluorides were developed and their properties were investigated. These compounds were shown to be convenient synthetic precursors for obtaining esters and amides of natural prostaglandins and their fluorodeoxy analogues.