disodium salt of 1-sulfomethyl-tetrazol-5-yl-thiol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: disodium salt of 1-sulfomethyl-tetrazol-5-yl-thiol
• 英文别名: disodium salt of 1-sulphomethyltetrazol-5-thiol；1-sulfomethyltetrazole-5-thiol disodium salt；5-mercapto-1-sulfomethyltetrazole disodium salt；1-sulphomethyl-1,2,3,4-tetrazole-5-thiol disodium salt；1-Sulphomethyl-5-mercapto-1,2,3,4-tetrazole disodium salt；1-sulfomethyltetrazol-5-thiol disodium salt；sodium;(5-sulfanylidene-2H-tetrazol-1-yl)methanesulfonate
• 化学式: 2C₂H₃N₄O₃S₂*2Na
• 分子量: 436.385
• InChiKey: ICDOJLHGNRCMRX-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.16
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  138
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  disodium salt of 1-sulfomethyl-tetrazol-5-yl-thiol 、 头孢噻吩 生成 3-(((1-(sulfomethyl)-1H-tetrazol-5-yl)thio)methyl)-7-(2-(2-thienyl)acetamido)-3-cephem-4-carboxylic acid
  参考文献：
  名称：

  Cephalosporin displacement reaction

  摘要：

  本发明涉及一种在有机溶剂和基本无水条件下，通过硫亲核试剂取代头孢菌酸中的乙酰氧基的过程。

  公开号：

  US04144391A1

文献信息

• Ketoiminocephalosporin derivatives
  申请人：ISF S.p.A.

  公开号：US04465831A1

  公开（公告）日：1984-08-14

  There is described a new class of ketohydroxyimino derivatives of cephalosporins of the formula ##STR1## wherein: R is an alkyl radical having from 2 to 4 carbon atoms, a phenyl, or a 5-membered heterocyclic radical which may be substituted, containing nitrogen, oxygen and/or sulphur; R.sup.1 is an acetoxy, carbamoyloxy or S-heterocyclic group, which may be substituted, and the heterocyclic ring is a 5- or 6-membered ring containing one or more nitrogen atoms, alone or combined with sulphur; R.sup.2 is hydrogen, alkyl or acetyl. The present compounds have an interesting broad-spectrum antibacterial activity.

  描述了头孢菌素的新类羰基羟亚胺衍生物，化学式为##STR1##其中：R是具有2至4个碳原子的烷基基团，苯基或可能被取代的含氮、氧和/或硫的5元杂环基团；R.sup.1是乙酰氧基、氨基甲酰氧基或S-杂环基团，可能被取代，杂环环是含有一个或多个氮原子的5-或6-成员环，单独或与硫结合；R.sup.2是氢、烷基或乙酰基。这些化合物具有广谱抗菌活性。
• 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)
  申请人：SmithKline Corporation

  公开号：US04159373A1

  公开（公告）日：1979-06-26

  The compounds of this invention are cephalosporins having a 3- or 4-aminomethylphenylacetamido substituent at the 7-position and a sulfonic acid substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus. The compounds have antibacterial activity.

  本发明的化合物是头孢菌素，其在7位具有3-或4-氨甲基苯乙酰胺基取代基，并且在头孢菌素核的3位具有磺酸取代的四唑硫甲基基团。这些化合物具有抗菌活性。
• Cephalosporin displacement reaction
  申请人：Eli Lilly and Company

  公开号：US04144391A1

  公开（公告）日：1979-03-13

  The present invention is directed to a process for the displacement of the acetoxy group of a cephalosporanic acid by a sulfur nucleophile, in an organic solvent and under essentially anhydrous conditions.

  本发明涉及一种在有机溶剂和基本无水条件下，通过硫亲核试剂取代头孢菌酸中的乙酰氧基的过程。