(+/-)-8-hydroxy-6-mercapto-octanoic acid | 101567-87-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: (+/-)-8-hydroxy-6-mercapto-octanoic acid
• 英文别名: (+/-)-8-Hydroxy-6-mercapto-octansaeure；8-Hydroxy-6-sulfanyloctanoic acid
• CAS: 101567-87-7
• 化学式: C₈H₁₆O₃S
• 分子量: 192.279
• InChiKey: HEWOAJYAACUECT-UHFFFAOYSA-N

物化性质

• 熔点：
  45-47.5 °C
• 沸点：
  356.7±37.0 °C(Predicted)
• 密度：
  1.150±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  58.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (+/-)-8-hydroxy-6-mercapto-octanoic acid 、 硫脲 在 氢溴酸 作用下， 生成 (+/-)-二氢硫辛酸
  参考文献：
  名称：

  Synthesis of (+)-α-Lipoic Acid and its Optical Antipode¹

  摘要：

  DOI：

  10.1021/ja01624a057
• 作为产物：
  描述：

  (+/-)-3-acetylsulfanyl-octanedioic acid-8-ethyl ester-1-chloride 在 1,4-二氧六环 、 硼酸三钠 作用下， 生成 (+/-)-8-hydroxy-6-mercapto-octanoic acid
  参考文献：
  名称：

  Synthesis of (+)-α-Lipoic Acid and its Optical Antipode¹

  摘要：

  DOI：

  10.1021/ja01624a057

文献信息

• Novel antibacterial agents
  申请人：Christensen G. Burton

  公开号：US20070196859A1

  公开（公告）日：2007-08-23

  This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked ) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, penicillinase enzyme, cephalosporinase enzyme, a transglycosylase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.
• Synthesis of (+)-α-Lipoic Acid and its Optical Antipode¹
  作者：Edward Walton、Arthur F. Wagner、Frank W. Bachelor、Louis H. Peterson、Frederick W. Holly、Karl Folkers

  DOI：10.1021/ja01624a057

  日期：1955.10