2-amino-N-dodecyl-3-(1H-imidazole-4-yl)propanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-N-dodecyl-3-(1H-imidazole-4-yl)propanamide
• 英文别名: 2-amino-N-dodecyl-3-(1h-imidazol-5-yl)propanamide
• 化学式: C₁₈H₃₄N₄O
• 分子量: 322.494
• InChiKey: CXYGRDSHYNQUQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  83.8
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-amino-N-dodecyl-3-(1H-imidazole-4-yl)propanamide 在 钯 叠氮磷酸二苯酯 、 氢气 作用下， 生成 6-[(2-Amino-ethylamino)-methyl]-pyridine-2-carboxylic acid [1-dodecylcarbamoyl-2-(1H-imidazol-4-yl)-ethyl]-amide
  参考文献：
  名称：

  Enantiomeric bleomycin model compounds bearing long alkyl-chain

  摘要：

  Enantiomeric bleomycin model compounds bearing long alkyl-chain were synthesized and the physicochemical properties of their metal complexes were studied. The Fe complexes of these compounds exhibited a strong DNA cleaving activity in a chiral discriminative manner.

  DOI：

  10.1016/0040-4039(91)80429-a
• 作为产物：
  描述：

  D,L-histidine 在 钯 叠氮磷酸二苯酯 、 氢气 作用下， 生成 2-amino-N-dodecyl-3-(1H-imidazole-4-yl)propanamide
  参考文献：
  名称：

  Enantiomeric bleomycin model compounds bearing long alkyl-chain

  摘要：

  Enantiomeric bleomycin model compounds bearing long alkyl-chain were synthesized and the physicochemical properties of their metal complexes were studied. The Fe complexes of these compounds exhibited a strong DNA cleaving activity in a chiral discriminative manner.

  DOI：

  10.1016/0040-4039(91)80429-a

文献信息

• Syntheses and Catalytic Actions of Self-Micelle-Forming Hydrolase Models
  作者：Kazuo Kawaguchi、Yasukazu Ohkatsu、Tom Kusano

  DOI：10.1246/bcsj.63.442

  日期：1990.2

  Hydrolase model catalysts, N-alkyl-Nα-[2-(d-polyhydroxypentyl)-3-acetyl-4-thiazolidinylcarbonyl]-l-histidinamide (acyclic-type catalyst) and N-(N-alkanoyl-l-nistidyl)-β-d-glucosamine (cyclic-type catalyst), which easily form micelles in water by themselves, have been designed and the stereostructural effects of sugar moieties examined on stereoselective hydrolyses of p-nitrophenyl N-benzyloxycarbonyl-l-(or d-)phenylalaninates. An acyclic-type catalyst is l-selective, while a cyclic-type catalyst is l-selective. The stereorecognition of acyclictype catalysts was found to be performed by a sugar moiety, rather than the histidyl type. Comparisons of the activities of three acyclic-type catalysts having different sugar moieties show that a mannose-derived catalyst is the most stereoselective. Judging from kinetic data, it is concluded that the configuration of OH on C-3 of the sugar moiety takes a significant part in the stereorecognition of a catalyst.
• Enantiomeric bleomycin model compounds bearing long alkyl-chain
  作者：Kazuo Shinozuka、Hiromasa Morishita、Tsutomu Yamazaki、Yukio Sugiura、Hiroaki Sawai

  DOI：10.1016/0040-4039(91)80429-a

  日期：1991.11

  Enantiomeric bleomycin model compounds bearing long alkyl-chain were synthesized and the physicochemical properties of their metal complexes were studied. The Fe complexes of these compounds exhibited a strong DNA cleaving activity in a chiral discriminative manner.