lysidiside W | 1340542-84-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: lysidiside W
• 英文别名: 1-[3-[(2S,3S,4R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-methylbutan-1-one
• CAS: 1340542-84-8
• 化学式: C₃₂H₃₆O₁₅
• 分子量: 660.629
• InChiKey: FCLBDWCAWGPSLA-GFJLKBKBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  47
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  267
• 氢给体数：
  11
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  lysidiside W 在 helicase 、 水 作用下， 反应 12.0h， 生成 D-葡萄糖 、
  参考文献：
  名称：

  Antioxidative acylphloroglucinols from the roots of Lysidice rhodostegia

  摘要：

  Four new acylphloroglucinols, lysidicins I and J (1 and 2), and lysidisides V and W (3 and 4), were isolated from the roots of Lysidice rhodostegia. Among them, compound 1 is a novel acylphloroglucinol, and compound 2 is the first naturally occurring acylphloroglucinol derivative with an uncommon spiro(benzofuran-[2H]pyran) skeleton. Their structures were elucidated by spectroscopic and chemical methods. The absolute configuration of 1 was assigned by employing dimolybdenum tetraacetate-induced CD spectrum method, and that of 2 was determined by analysis of their experimental and theoretically calculated CD spectra. Compounds 3 and 4 exhibited potent antioxidative activity with IC(50) values of 3.29 and 3.39 mu M, respectively. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.08.034

文献信息

• Antioxidative acylphloroglucinols from the roots of Lysidice rhodostegia
  作者：Xian-Fu Wu、Ya-Dan Wang、Shi-Shan Yu、Nan Jiang、Jing Ma、Ren-Xiang Tan、You-Cai Hu、Jing Qu

  DOI：10.1016/j.tet.2011.08.034

  日期：2011.10

  Four new acylphloroglucinols, lysidicins I and J (1 and 2), and lysidisides V and W (3 and 4), were isolated from the roots of Lysidice rhodostegia. Among them, compound 1 is a novel acylphloroglucinol, and compound 2 is the first naturally occurring acylphloroglucinol derivative with an uncommon spiro(benzofuran-[2H]pyran) skeleton. Their structures were elucidated by spectroscopic and chemical methods. The absolute configuration of 1 was assigned by employing dimolybdenum tetraacetate-induced CD spectrum method, and that of 2 was determined by analysis of their experimental and theoretically calculated CD spectra. Compounds 3 and 4 exhibited potent antioxidative activity with IC(50) values of 3.29 and 3.39 mu M, respectively. (C) 2011 Elsevier Ltd. All rights reserved.