2-[2-(3-Methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]ethyl methanesulfonate | 647005-87-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[2-(3-Methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]ethyl methanesulfonate
• 英文别名: 2-[2-(3-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]ethyl methanesulfonate
• CAS: 647005-87-6
• 化学式: C₁₄H₁₇NO₅S
• 分子量: 311.359
• InChiKey: RTIBYEGQQIGHIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  87
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[2-(3-Methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]ethyl methanesulfonate 、 tert-butyl (2S,3S)-1-(4-tert-butylphenyl)-3-[(3-hydroxyphenyl)methyl]-4-oxoazetidine-2-carboxylate 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists

  摘要：

  A novel class of azetidinone acid-derived dual PPAR alpha/gamma agonists has been synthesized for the treatment of diabetes and dyslipidemia. The preferred stereochemistry in this series for binding and functional agonist activity against both PPAR alpha and PPAR gamma receptors was shown to be 3S,4S. Synthesis, in vitro and in vivo activities of compounds in this series are described. A high-yielding method for N-arylation of azetidinone esters is also described. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.01.126

文献信息

• US7951793B2
  申请人：——

  公开号：US7951793B2

  公开（公告）日：2011-05-31
• Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists
  作者：Wei Wang、Pratik Devasthale、Dennis Farrelly、Liqun Gu、Thomas Harrity、Michael Cap、Cuixia Chu、Lori Kunselman、Nathan Morgan、Randy Ponticiello、Rachel Zebo、Litao Zhang、Kenneth Locke、Jonathan Lippy、Kevin O’Malley、Vinayak Hosagrahara、Lisa Zhang、Pathanjali Kadiyala、Chiehying Chang、Jodi Muckelbauer、Arthur M. Doweyko、Robert Zahler、Denis Ryono、Narayanan Hariharan、Peter T.W. Cheng

  DOI：10.1016/j.bmcl.2008.01.126

  日期：2008.3

  A novel class of azetidinone acid-derived dual PPAR alpha/gamma agonists has been synthesized for the treatment of diabetes and dyslipidemia. The preferred stereochemistry in this series for binding and functional agonist activity against both PPAR alpha and PPAR gamma receptors was shown to be 3S,4S. Synthesis, in vitro and in vivo activities of compounds in this series are described. A high-yielding method for N-arylation of azetidinone esters is also described. (C) 2008 Elsevier Ltd. All rights reserved.