(4-amino-5,7-dibromopyrrolo[2,1-f][1,2,4]triazin-6-yl)methanol | 1443531-74-5

分子结构分类

有机化合物 - 有机杂环化合物 - 吡咯并三嗪类

中文名称

——

中文别名

——

英文名称

(4-amino-5,7-dibromopyrrolo[2,1-f][1,2,4]triazin-6-yl)methanol

英文别名

4-Amino-5,7-dibromopyrrolo[2,1-f][1,2,4]triazine-6-methanol

(4-amino-5,7-dibromopyrrolo[2,1-f][1,2,4]triazin-6-yl)methanol化学式

CAS

1443531-74-5

化学式

C₇H₆Br₂N₄O

mdl

——

分子量

321.959

InChiKey

NSDFGGPKCWFCSL-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

0.9
重原子数：

14
可旋转键数：

1
环数：

2.0
sp3杂化的碳原子比例：

0.14
拓扑面积：

76.4
氢给体数：

2
氢受体数：

4

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	(4-aminopyrrolo[2,1-f][1,2,4]triazin-6-yl)methanol	939807-71-3	C₇H₈N₄O	164.167
——	ethyl 4-aminopyrrolo[2,1-f][1,2,4]triazine-6-carboxylate	939808-08-9	C₉H₁₀N₄O₂	206.204
4-氨基吡咯并[1,2-f][1,2,4]三嗪-6-甲腈	4-aminopyrrolo[2,1-f][1,2,4]triazine-6-carbonitrile	937049-27-9	C₇H₅N₅	159.15

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	5,7-dibromo-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine	1443531-99-4	C₁₃H₂₀Br₂N₄OSi	436.221
——	(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-6-yl)methanol	1443531-75-6	C₇H₇BrN₄O	243.063
——	4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde	1443616-55-4	C₇H₅BrN₄O	241.047
——	4-[(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-6-yl)methyl]piperazin-2-one	1443616-56-5	C₁₁H₁₃BrN₆O	325.168
——	2-[4-amino-5-bromo-6-(hydroxymethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]propan-2-ol	1443532-01-1	C₁₀H₁₃BrN₄O₂	301.143
——	2-[4-amino-5-bromo-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-propan-2-ol	1443532-00-0	C₁₆H₂₇BrN₄O₂Si	415.405
——	6-(ethoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine	1443531-78-9	C₁₉H₂₀N₄O₂S	368.459
——	US9598416, Example 40	1443616-99-6	C₁₉H₁₇N₅O₂S	379.442
——	6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine	1443531-77-8	C₁₈H₁₈N₄O₂S	354.433
——	[4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methanol	1443531-76-7	C₁₇H₁₆N₄O₂S	340.406
——	4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid	1443616-93-0	C₁₇H₁₄N₄O₃S	354.389
——	{[4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)-7-(piperazin-1-ylmethyl)pyrrolo[2,1-f]-[1,2,4]triazin-6-yl]methoxy}acetic acid	1443530-54-8	C₂₄H₂₈N₆O₄S	496.59
——	1-(4-{[4-amino-6-(ethoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f]-[1,2,4]triazin-7-yl]methyl}piperazin-1-yl)ethanone	1443530-35-5	C₂₆H₃₂N₆O₃S	508.644
——	1-(4-{[4-amino-6-(hydroxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f]-[1,2,4]triazin-7-yl]methyl}piperazin-1-yl)ethanone	1443530-78-6	C₂₄H₂₈N₆O₃S	480.591
——	6-(ethoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)-7-(piperazin-1-ylmethyl)-pyrrolo[2,1-f][1,2,4]triazin-4-amine	1443530-33-3	C₂₄H₃₀N₆O₂S	466.607
——	6-[(cyclobutyloxy)methyl]-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)-7-(piperazin-1-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine	1443530-45-7	C₂₆H₃₂N₆O₂S	492.645
——	methyl {[4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)-7-(piperazin-1-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methoxy}acetate	1443530-53-7	C₂₅H₃₀N₆O₄S	510.617
——	2-({7-[(4-acetylpiperazin-1-yl)methyl]-4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}methoxy)acetamide	1443530-56-0	C₂₆H₃₁N₇O₄S	537.643
——	[4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)-7-(morpholin-4-ylmethyl)pyrrolo-[2,1-f][1,2,4]triazin-6-yl]methanol	1443530-73-1	C₂₂H₂₅N₅O₃S	439.538
——	4-{[4-amino-6-(ethoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f]-[1,2,4]triazin-7-yl]methyl}piperazin-2-one	1443530-13-9	C₂₄H₂₈N₆O₃S	480.591
——	2-[4-amino-6-(hydroxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f]-[1,2,4]triazin-7-yl]propan-2-ol	1443531-00-7	C₂₀H₂₂N₄O₃S	398.486
——	2-{[4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)-7-(piperazin-1-ylmethyl)pyrrolo-[2,1-f][1,2,4]triazin-6-yl]methoxy}acetamide	1443530-55-9	C₂₄H₂₉N₇O₃S	495.605
——	tert-butyl 4-{[4-amino-6-(hydroxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl}piperazine-1-carboxylate	1443531-79-0	C₂₇H₃₄N₆O₄S	538.671
——	tert-butyl 4-({4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)-6-[(2-methoxy-2-oxoethoxy)methyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}methyl)piperazine-1-carboxylate	1443531-80-3	C₃₀H₃₈N₆O₆S	610.734
——	4-{[4-amino-6-(hydroxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f]-[1,2,4]triazin-7-yl]methyl}piperazin-2-one	1443530-27-5	C₂₂H₂₄N₆O₃S	452.537
罗加替尼	4-{[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl}piperazin-2-one	1443530-05-9	C₂₃H₂₆N₆O₃S	466.564
——	1-(4-{[4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methyl}piperazin-1-yl)ethanone	1443616-80-5	C₂₃H₂₆N₆O₂S	450.564
——	5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)-6-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine	1443616-83-8	C₂₁H₂₃N₅O₂S	409.512
——	N-{[4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methyl}acetamide	1443616-67-8	C₁₉H₁₉N₅O₂S	381.458
——	4-{[4-amino-5-(7-methoxy-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methyl}piperazin-2-one	1443616-90-7	C₂₀H₂₀N₆O₂S	408.484
——	N²-{[4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methyl}-N-methylglycinamide	1443616-71-4	C₂₀H₂₂N₆O₂S	410.5
——	6-(azidomethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine	1443616-53-2	C₁₇H₁₅N₇OS	365.418
——	N²-{[4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methyl}glycinamide	1443616-75-8	C₁₉H₂₀N₆O₂S	396.473
——	4-{[4-amino-7-(2-hydroxypropan-2-yl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo-[2,1-f][1,2,4]triazin-6-yl]methyl}piperazin-2-one	1443531-01-8	C₂₄H₂₈N₆O₃S	480.591
——	N-({7-[(4-acetylpiperazin-1-yl)methyl]-4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}methyl)acetamide	1443530-93-5	C₂₆H₃₁N₇O₃S	521.643
——	N²-{[4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6yl]methyl}-N²-methylglycinamide	1443616-72-5	C₂₀H₂₂N₆O₂S	410.5
——	US9598416, Example 46	1443617-05-7	C₂₁H₂₂N₆OS	406.511
——	4-{[4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methyl}piperazin-2-one	1443616-69-0	C₂₁H₂₂N₆O₂S	422.511
——	1-(4-{[4-amino-6-{[(2-hydroxy-2-methylpropyl)amino]methyl}-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl}piperazin-1-yl)ethanone	1443530-80-0	C₂₈H₃₇N₇O₃S	551.713
——	tert-butyl 4-{[6-(acetamidomethyl)-4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl}piperazine-1-carboxylate	1443531-88-1	C₂₉H₃₇N₇O₄S	579.723