N-(1-benzoyl-5-chloro-2-phenylindol-3-yl)benzamide | 1284218-87-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(1-benzoyl-5-chloro-2-phenylindol-3-yl)benzamide
• CAS: 1284218-87-6
• 化学式: C₂₈H₁₉ClN₂O₂
• 分子量: 450.924
• InChiKey: CBFCUGNPLIDIJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基-5-氯苯腈 在 indium 、 N,N-二异丙基乙胺 、 3-溴丙烯 作用下， 以 四氢呋喃 、 乙醇 、 甲苯 为溶剂， 反应 30.67h， 生成 N-(1-benzoyl-5-chloro-2-phenylindol-3-yl)benzamide
  参考文献：
  名称：

  Synthesis of 3-aminoindole derivatives: combination of Thorpe–Ziegler cyclization and unexpected allylindium-mediated decyanation

  摘要：

  alpha-Anilinonitriles were unexpectedly converted to 3-iminodihydroindoles via the Thorpe-Ziegler cyclization during the benzoylation. 3-Iminodihydroindoles were transformed to 3-aminoindoles in good yields via an allylindium-mediated decyanative aromatization. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.085

文献信息

• Synthesis of 3-aminoindole derivatives: combination of Thorpe–Ziegler cyclization and unexpected allylindium-mediated decyanation
  作者：Yu Mi Kim、Ko Hoon Kim、Sunhong Park、Jae Nyoung Kim

  DOI：10.1016/j.tetlet.2011.01.085

  日期：2011.3

  alpha-Anilinonitriles were unexpectedly converted to 3-iminodihydroindoles via the Thorpe-Ziegler cyclization during the benzoylation. 3-Iminodihydroindoles were transformed to 3-aminoindoles in good yields via an allylindium-mediated decyanative aromatization. (C) 2011 Elsevier Ltd. All rights reserved.