Serin-Natriumsalz

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Serin-Natriumsalz
• 英文别名: Sodium serinate；sodium;(2S)-2-amino-3-hydroxypropanoate
• 化学式: C₃H₆NO₃*Na
• 分子量: 127.075
• InChiKey: SOKFOILSVPHVCU-DKWTVANSSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -5.94
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  86.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Serin-Natriumsalz 、 氯化(1-丁基-3-甲基咪唑) 以 丙酮 为溶剂， 反应 24.0h， 以83%的产率得到[bmim][Ser]
  参考文献：
  名称：

  手性离子液体存在下对甲基苯硫醚的立体选择性氧化

  摘要：

  已经制备了几种在阳离子或阴离子中包含手性中心的离子液体。它们已被用作甲基苯硫醚的立体选择性氧化以获得相应亚砜的催化剂和溶剂。

  DOI：

  10.1134/s1070363214070093
• 作为产物：
  描述：

  L-丝氨酸 在 sodium hydroxide 作用下， 生成 Serin-Natriumsalz
  参考文献：
  名称：

  Hydration of Amino Acids from Ultrasonic Measurements

  摘要：

  In this paper the results of compressibility of aqueous solutions of amino acids in water and in aqueous HCl and NaOH solutions at 25 degrees C are presented. The effect of the charged protonated amino groups and deprotonated carboxylic groups on the hydration number was tested. The idea of additivity of the hydration number with the constituents of the solute molecule was successfully applied and discussed.

  DOI：

  10.1021/jp105255b
• 作为试剂：
  描述：

  N-((1E,3S,4S,5E)-7-(benzyloxy)-1-iodo-3,5-dimethylhepta-1,5-dien-4-yl)-N-methyl-7-oxoheptanamide 在 nickel dichloride chromium dichloride 、 水 、 Serin-Natriumsalz 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 13.0h， 生成 (11S,12S,E)-12-((E)-4-(benzyloxy)but-2-en-2-yl)-8-hydroxy-1,11-dimethylazacyclododec-9-en-2-one
  参考文献：
  名称：

  12 MEMBERED-RING MACROLACTAM DERIVATIVES

  摘要：

  提供了一种具有抗肿瘤活性的12-成员环大环内酰胺衍生物：由化学式（1）表示的化合物或其盐。在该化学式中，R1是氢原子、C1-6烷基基团、C1-6烷基羰基基团或C6-14芳基羰基基团；R2是氢原子或C1-6烷基基团；R3是氢原子或羟基；R4是氢原子或羟基；R5是氢原子或C1-6烷基基团；R6是氢原子或羟基；R7是乙酰基或类似物。

  公开号：

  US20080312317A1

文献信息

• Reactions of amino-acids co-ordinated to metal ions. Part 1. Investigation of the condensation of formaldehyde and metal-co-ordinated glycine
  作者：Luigi Casella、Alessandro Pasini、Renato Ugo、Mario Visca

  DOI：10.1039/dt9800001655

  日期：——

  The condensation reaction of formaldehyde with glycine or glycine Schiff bases co-ordinated to CoIII, CuII, and NiII has been studied. The reaction leads invariably to α-hydroxymethylserine. The influence of the metal ion, the charge of the complex, pH, and the ratio of the reactants are discussed, together with the effect of Schiff-base formation. With [Cu(glyO)2](glyO = glycinate) the condensation

  研究了甲醛与与Co III，Cu II和Ni II配位的甘氨酸或甘氨酸席夫碱的缩合反应。反应总是导致α-羟甲基丝氨酸。讨论了金属离子，配合物的电荷，pH和反应物比例的影响，以及席夫碱形成的影响。对于[Cu（glyO）2 ]（glyO =甘氨酸盐），甲醛在α-碳原子上的缩合先于氨基上的缩合，然后环化生成恶唑烷型环。在[Co（en）2（glyO）] 2+（en =乙二胺）的情况下，尚未获得这种机制的证据。
• α-Glucosidase inhibitory activities of phenolic acid amides with <scp>l</scp>-amino acid moiety
  作者：Bin Liu、Ji-Mei Ma、Hang-Wei Chen、Zi-Long Li、Lin-Hao Sun、Zhen Zeng、Hong Jiang

  DOI：10.1039/c6ra08330g

  日期：——

  control postprandial hyperglycemia. In this study, a series of phenolic acids with the L-amino acid moiety were synthesized and their inhibitory activities against α-glucosidase from Saccharomyces cerevisiae (EC 3.2.1.20) were evaluated. The results suggested that all these compounds showed strong α-glucosidase inhibitory activities. In particular, N-(4-hydroxyl-phenylpropenoyl)-L-alanine (c2) and N-

  α-葡萄糖苷酶抑制剂可有效控制餐后高血糖。在这项研究中，合成了一系列具有L-氨基酸部分的酚酸，并评估了它们对酿酒酵母（EC 3.2.1.20）对α-葡萄糖苷酶的抑制活性。结果表明所有这些化合物均显示出强的α-葡萄糖苷酶抑制活性。尤其是，N-（4-羟基-苯基丙烯酰基）-L-丙氨酸（c2）和N-（4-羟基-苯基丙烯酰基）-L-蛋氨酸（c8）的效能（IC 50值为0.04 mM）远高于阳性。控制，阿卡波糖（IC 50值1.70 mM）。建立了用于比较分子场分析（CoMFA）的三维定量构效关系（3D-QSAR）模型，结果表明氨基酸残基上的本体基团和高电子密度基团对其活性有所帮助。此外，在苯环的对位上具有低电子密度和小的位阻的取代基有助于改善活性。动力学分析表明，化合物（C2充当与混合型抑制剂）ķ我0.0124毫值。对接分析表明，它们可以通过氢键和π-π堆积与催化位点的α-葡萄糖苷酶结合。
• Boron compounds and complexes as anti-inflammatory agents
  申请人：——

  公开号：US06696419B1

  公开（公告）日：2004-02-24

  Inflammation is affected by topical application of a boron containing compound/complex in which a central tetrahedral boron atom is covalently bound to four ligands. At least one of the ligands preferably includes an oxygen, nitrogen, carbon, or sulfur atom, and preferably all four ligands include at least one such atom. Preferred ligands are saccharides and amino acids, including fructose, sorbitol, mannitol, xylitol, sorbose, serine and threonine. Especially preferred ligands have a conformation with at least two hydroxyl groups, or one hydroxyl group and one amino group in a 1,2- and a 1,3-position relative to each other, providing a high association constant in the range of about 3,000 and about 20,000. The compounds/complexes are preferably provided in formulations which provide good transdermal delivery, including appropriate solvent systems, microemulsions, liposomes. Particularly targeted inflammations are those of the joints and skin, including bums such as sunburn.

  一种含硼化合物/复合物的局部应用会影响炎症，其中一个中心四面体硼原子与四个配体共价结合。至少一个配体最好包括氧、氮、碳或硫原子，而且最好所有四个配体都包含至少一个这样的原子。优选的配体是糖类和氨基酸，包括果糖、山梨醇、甘露醇、木糖醇、山梨糖、丝氨酸和苏氨酸。特别优选的配体具有至少两个羟基或一个羟基和一个氨基在1,2-和1,3-位置相对排列的构象，提供约3,000至约20,000范围内的高关联常数。这些化合物/复合物最好以提供良好经皮递送的配方形式提供，包括适当的溶剂体系、微乳液、脂质体。特别针对的炎症是关节和皮肤的炎症，包括晒伤等。
• Enzyme inhibitors and methods therefor
  申请人：——

  公开号：US20040110724A1

  公开（公告）日：2004-06-10

  An enzyme is inhibited by presenting the enzyme with a boron containing structure having a tetrahedral boron atom covalently bound to four ligands. Particularly preferred enzymes include prostaglandin endoperoxide synthase (COX-1 and COX-2), and particularly preferred structures include a ligand that confers at least 80-fold selectivity of COX-2 inhibition over COX-1 inhibition. Consequently, further methods are directed towards induction of apoptosis in a cell and methods of reducing pain.

  一种酶可以通过提供一个含有四个配体共价结合的四面体硼原子的硼结构来被抑制。特别优选的酶包括前列腺素内过氧化物合酶（COX-1和COX-2），特别优选的结构包括一个配体，其使COX-2抑制比COX-1抑制至少高80倍。因此，进一步的方法是针对诱导细胞凋亡和减轻疼痛的方法。
• Boron compounds/complexes to control hair growth, and methods of use
  申请人：——

  公开号：US05985842A1

  公开（公告）日：1999-11-16

  Hair growth is affected by topical application of a boron containing compounds/complexes in which a central tetrahedral boron atom is covalently bound to four ligands. At least one of the ligands preferably includes an oxygen, nitrogen, carbon, or sulfur atom, and preferably all four ligands include at least one such atom. Preferred ligands are saccharides and amino acids, including fructose, sorbitol, mannitol, xylitol, sorbose, serine and threonine. Especially preferred ligands have a conformation with at least two hydroxyl groups, or one hydroxyl group and one amino group in a 1,2- and a 1,3- position relative to each other, providing a high association constant in the range of about 3,000 and about 20,000. The compounds/complexes are preferably provided in formulations which provide good transdermal delivery, including appropriate solvent systems, microemulsions, liposomes.

  使用含硼化合物/配合物的局部应用会影响头发生长，其中一个中心四面体硼原子与四个配体共价结合。至少一个配体最好包括一个氧、氮、碳或硫原子，而且最好所有四个配体都包括至少一个这样的原子。优选的配体是糖类和氨基酸，包括果糖、山梨醇、甘露醇、木糖醇、山梨糖、丝氨酸和苏氨酸。特别优选的配体具有至少两个羟基，或一个羟基和一个氨基在1,2-和1,3-位置相对于彼此，提供约3,000至20,000的高关联常数。这些化合物/配合物最好以提供良好的经皮递送的制剂形式提供，包括适当的溶剂系统、微乳液和脂质体。