α-Propyloxy-propionsaeure-aethylester | 41918-10-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: α-Propyloxy-propionsaeure-aethylester
• 英文别名: 2-Propoxy-propionic acid ethyl ester；ethyl 2-propoxypropanoate
• CAS: 41918-10-9
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: KGPIFKMWQYGTAU-UHFFFAOYSA-N

物化性质

• 沸点：
  203.9±13.0 °C(Predicted)
• 密度：
  0.937±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  α-Propyloxy-propionsaeure-aethylester 在 lithium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 生成 2-propoxy-propionic acid
  参考文献：
  名称：

  Synthesis of probes for the active site of leucine dehydrogenase

  摘要：

  A series of novel 3-substituted 2-oxobutanoic acids were prepared and incubated with leucine dehydrogenase giving in one case both a kinetic resolution at C-3 and reductive amination of the ketone. This is the first example of an amino acid dehydrogenase catalysed kinetic resolution and reductive amination. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00297-8
• 作为产物：
  描述：

  ethyl 2-(allyloxy)propanoate 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 α-Propyloxy-propionsaeure-aethylester
  参考文献：
  名称：

  Synthesis of probes for the active site of leucine dehydrogenase

  摘要：

  A series of novel 3-substituted 2-oxobutanoic acids were prepared and incubated with leucine dehydrogenase giving in one case both a kinetic resolution at C-3 and reductive amination of the ketone. This is the first example of an amino acid dehydrogenase catalysed kinetic resolution and reductive amination. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00297-8

文献信息

• Modulators of peroxisome proliferator activated receptors
  申请人：Brooks Alisa Dawn

  公开号：US20050020684A1

  公开（公告）日：2005-01-27

  Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH 2 — or —CH 2 CH 2 —; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R 1 and W, R 2 is (CH 2 ) n —CH(OR 2 )—(CH 2 ) n E, —(CH)═C(OR 2 )—(CH 2 ) n E, —(CH 2 ) n —CH(Y)—(CH 2 ) m E or (CH)═C(Y)(CH 2 ) m E; wherein E is COOR 3 , C 1 -C 3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C 1 -C 6 alkyl, haloalkyl and aryl-C o - 4 -alkyl; R 2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR 4 , —COOR 4 , —CONR 5 R 6 , —C(S)R 4 , —C(S)OR 4 or C(S)NR 5 R 6 , R 3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O—, CH 2 —, CH 2 CH 2 — or CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R 1 . R 4 -R 6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2.

  本发明公开了一种由结构式（I）表示的化合物：其中Ar是取代或未取代的芳香基团。Q是共价键，-CH2-或-CH2CH2-; W是取代或未取代的烷基或取代或未取代的异烷基连接基，长度为两到十个原子，优选长度为两到七个原子。苯环A可选地与R1和W以外的最多四个取代基取代，R2是（CH2）n-CH（OR2）-（CH2）nE，-（CH）=C（OR2）-（CH2）nE，-（CH2）n-CH（Y）-（CH2）mE或（CH）=C（Y）（CH2）mE;其中E是COOR3，C1-C3烷基腈，羧酰胺，磺酰胺，酰基磺酰胺或四唑，磺酰胺，酰基磺酰胺和四唑可选地与一个或多个取代基取代，独立地选自：C1-C6烷基，卤代烷基和芳基-Co-4-烷基; R2是H，脂肪基，取代脂肪基，卤代烷基，芳基，取代芳基，-COR4，-COOR4，-CONR5R6，-C（S）R4，-C（S）OR4或C（S）NR5R6，R3是H，脂肪基，取代脂肪基，芳基或取代芳基。Y是O-，CH2-，CH2CH2-或CH═CH-，并与Phenyl环A中与R1相邻的碳原子键合。R4-R6独立地是H，脂肪基，取代脂肪基，芳基或取代芳基。n和m独立地为0、1或2。
• Alpha-substituted-propionic acid esters
  申请人：Chisso Corporation

  公开号：EP0267758A2

  公开（公告）日：1988-05-18

  An optically active compound exhibiting high speed response properties when used as a component of liquid crystal materials used in a liquid crystal display mode utilizing ferroelectricity, and a liquid crystal compo­sition containing the compound are provided, which compund is expressed by the formula wherein R¹ represents alkyl, alkoxy or alkoxycarbonyl each of 2 to 18 C, R² represents alkyl of 3 to 18C or alkoxy of 1 to 18C and A represents a member selected from a group of two directly bonded six-membered rings having a halogen atom, cyano group, methyl group or trifluoromethyl group attached thereonto and * represents an unsymmetric carbon atom.

  本发明提供了一种在用作利用铁电性的液晶显示模式中所用液晶材料的成分时具有高速响应特性的光学活性化合物，以及一种含有该化合物的液晶组合物，该组合物由式表示 其中，R¹分别代表 2 至 18C 的烷基、烷氧基或烷氧基羰基，R²代表 3 至 18C 的烷基或 1 至 18C 的烷氧基，A 代表选自两个直接结合的六元环的成员，该组环上连接有卤素原子、氰基、甲基或三氟甲基，*代表不对称碳原子。
• Radiation sensitive resin composition for forming a protective film, method of forming a protective film from the composition, liquid crystal display device and solid-state image sensing device
  申请人：JSR Corporation

  公开号：EP1972673A1

  公开（公告）日：2008-09-24

  A radiation sensitive resin composition for forming a protective film, comprising: [A] a copolymer of (a1) an unsaturated carboxylic acid and/or an unsaturated carboxylic anhydride, (a2) an epoxy group-containing unsaturated compound and (a3) an unsaturated compound different from the components (a1) and (a2) ; [B] a monofunctional polymerizable unsaturated compound having a molecular weight of 180 or more and a carboxyl group; [C] a polyfunctional polymerizable unsaturated compound; and [D] a photopolymerization initiator, a method of forming a protective film from the above composition and a protective film formed from the above composition. The composition can provide a cured film having high flatness, has high developability and heat resistance, is advantageously used to form a protective film for liquid crystal display devices and solid-state image sensing devices, and has high storage stability as a composition.

  一种用于形成保护膜的辐射敏感树脂组合物，包括 [A] (a1) 不饱和羧酸和/或不饱和羧酸酐、(a2) 含环氧基团的不饱和化合物和(a3) 不同于组分(a1)和(a2)的不饱和化合物的共聚物； [B] 单官能团可聚合不饱和化合物，分子量大于或等于 180，含有一个羧基； [C] 多官能团可聚合的不饱和化合物；以及 [D] 一种光聚合引发剂、 由上述组合物形成保护膜的方法，以及由上述组合物形成的保护膜。 该组合物可以提供具有高平整度、高显影性和耐热性的固化膜，可用于形成液晶显示设备和固态图像传感设备的保护膜，并且作为一种组合物具有高储存稳定性。
• TAKEHXARA, SADAO;TOKAJRIN, TADAO;ODZAVA, MASASI;OGAVA, XIROSI;FUDZISAVA, +
  作者：TAKEHXARA, SADAO、TOKAJRIN, TADAO、ODZAVA, MASASI、OGAVA, XIROSI、FUDZISAVA, +

  DOI：——

  日期：——
• RADIATION SENSITIVE RESIN COMPOSITION FOR FORMING A PROTECTIVE FILM, METHOD OF FORMING A PROTECTIVE FILM FROM THE COMPOSITION, LIQUID CRYSTAL DISPLAY DEVICE AND SOLID-STATE IMAGE SENSING DEVICE
  申请人：ITO Yukiko

  公开号：US20080233515A1

  公开（公告）日：2008-09-25

  A radiation sensitive resin composition for forming a protective film, comprising: [A] a copolymer of (a1) an unsaturated carboxylic acid and/or an unsaturated carboxylic anhydride, (a2) an epoxy group-containing unsaturated compound and (a3) an unsaturated compound different from the components (a1) and (a2); [B] a monofunctional polymerizable unsaturated compound having a molecular weight of 180 or more and a carboxyl group; [C] a polyfunctional polymerizable unsaturated compound; and [D] a photopolymerization initiator, a method of forming a protective film from the above composition and a protective film formed from the above composition. The composition can provide a cured film having high flatness, has high developability and heat resistance, is advantageously used to form a protective film for liquid crystal display devices and solid-state image sensing devices, and has high storage stability as a composition.