pregabalin p-toluenesulfonate | 1165805-07-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: pregabalin p-toluenesulfonate
• 英文别名: (3S)-3-(aminomethyl)-5-methylhexanoic acid;4-methylbenzenesulfonic acid
• CAS: 1165805-07-1
• 化学式: C₇H₈O₃S*C₈H₁₇NO₂
• 分子量: 331.433
• InChiKey: WVCAECDIQLHFNY-FJXQXJEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.32
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对甲苯磺酸 、 普瑞巴林 以 水 、 异丙醚 、 丙酮 为溶剂， 反应 24.0h， 生成 pregabalin p-toluenesulfonate
  参考文献：
  名称：

  PREGABALIN SALTS

  摘要：

  Pregabalin besylate和pregabalin tosylate是pregabalin的药物可接受酸盐，可在固态中分离，尤其是晶体状态，水溶性足够，且在固态和溶液中都很稳定。

  公开号：

  US20090170945A1

文献信息

• LINEAR POLYSACCHARIDE BASED FILM PRODUCTS
  申请人：MonoSol Rx LLC

  公开号：EP3229778A1

  公开（公告）日：2017-10-18
• [EN] PREGABALIN SALTS<br/>[FR] SELS DE PRÉGABALINE
  申请人：SYNTHON BV

  公开号：WO2009080365A1

  公开（公告）日：2009-07-02

  Pharmaceutically acceptable acid addition salts of pregabalin that are isolatable in solid state, particularly crystalline state, sufficiently soluble in water, and stable both in the solid state and in the solution, as well as methods of making the salts and pharmaceutical compositions comprising the salts.
• [EN] PREGABALIN COMPOSITIONS<br/>[FR] COMPOSITIONS DE PRÉGABALINE
  申请人：SYNTHON BV

  公开号：WO2010115612A2

  公开（公告）日：2010-10-14

  The invention relates to a solid pharmaceutical blend which comprises 100 parts of a pregabalin compound and at least 15 parts of a pregelatinized starch, wherein said blend is substantially free of lactose, and to a pharmaceutical capsule filling composition, which comprises a pregabalin compound, pregelatinized starch, and a lubricant; wherein said composition does not contain lactose, mannitol, or microcrystalline cellulose.
• [EN] LINEAR POLYSACCHARIDE BASED FILM PRODUCTS<br/>[FR] PRODUITS DE FILM À BASE DE POLYSACCHARIDE LINÉAIRE
  申请人：MONOSOL RX LLC

  公开号：WO2016094567A1

  公开（公告）日：2016-06-16

  Film products, especially suitable for oral delivery, which can be formed during manufacture in the form of large and/or heavy film strips or sheets and subsequently cut into uniform dosage units, each dosage unit being uniform in content and having distributed therein a linear polysaccharide, such as pullulan, a plasticizer, and an active component.
• PREGABALIN SALTS
  申请人：Westheim Raymond J. H.

  公开号：US20090170945A1

  公开（公告）日：2009-07-02

  Pregabalin besylate and pregabalin tosylate are pharmaceutically acceptable acid addition salts of pregabalin that are isolatable in solid state, particularly crystalline state, sufficiently soluble in water, and stable both in the solid state and in the solution.

  Pregabalin besylate和pregabalin tosylate是pregabalin的药物可接受酸盐，可在固态中分离，尤其是晶体状态，水溶性足够，且在固态和溶液中都很稳定。