2-cyclopropyl-4-isopropoxy-6-methoxy-5-pyrimidinecarbaldehyde | 552881-08-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-cyclopropyl-4-isopropoxy-6-methoxy-5-pyrimidinecarbaldehyde
• 英文别名: 2-Cyclopropyl-4-methoxy-6-propan-2-yloxypyrimidine-5-carbaldehyde；2-cyclopropyl-4-methoxy-6-propan-2-yloxypyrimidine-5-carbaldehyde
• CAS: 552881-08-0
• 化学式: C₁₂H₁₆N₂O₃
• 分子量: 236.271
• InChiKey: RSDUEIIFCVUXMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  61.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-cyclopropyl-4-isopropoxy-6-methoxy-5-pyrimidinecarbaldehyde 在 sodium chlorite 、 氨基磺酸 作用下， 以 水 、 叔丁醇 为溶剂， 反应 2.5h， 生成 2-cyclopropyl-4-isopropoxy-6-methoxy-5-pyrimidinecarboxylic acid
  参考文献：
  名称：

  [EN] PIPERIDYL DERIVATIVES AND THEIR USE AS TACHYKININ ANTAGONISTS
  [FR] DERIVES DE PIPERIDYLE

  摘要：

  公开号：

  WO2004111000A3

文献信息

• Benzhydryl derivatives
  申请人：Take Kazuhiko

  公开号：US20050171350A1

  公开（公告）日：2005-08-04

  A compound of the formula (I): in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.

  一种化合物的公式(I)：其中R1、R2、R3、R4、R5、R6、R7、R8和R9分别如描述中所定义，或其盐。本发明的目标化合物具有Tachykinin拮抗作用等药理活性，可用于制造用于治疗或预防Tachykinin介导疾病的药物。
• BENZHYDRYL DERIVATIVES
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1456201A1

  公开（公告）日：2004-09-15
• [EN] BENZHYDRYL DERIVATIVES<br/>[FR] DERIVES DE BENZHYDRYLE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2003053957A1

  公开（公告）日：2003-07-03

  A compound of the formula (I): wherein in which R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.
• [EN] PIPERIDYL DERIVATIVES<br/>[FR] DERIVES DE PIPERIDYLE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2004111000A2

  公开（公告）日：2004-12-23

  A compound of the formula (I): wherein R1, R2, R8, R9 and R10 are each as defined in the description, and -X- is -NH or -O-,Y is (II), (III), (IV), etc., and -Z- is bond or (V) in which R3, R4, R5, R6, R7, and R11 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.
• [EN] PIPERIDINE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS<br/>[FR] DÉRIVÉS DE PIPÉRIDINE COMME ANTAGONISTES DES RÉCEPTEURS DES TACHYKININES
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2007089031A1

  公开（公告）日：2007-08-09

  [EN] A novel piperidine derivative represented by the formula (I) (I) wherein Ar is a phenyl group optionally having substituent(s), R¿1? is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group or a heterocyclic group optionally having substituent(s), Z is a methylene group optionally having C?1-6#191 alkyl group(s), ring A is a piperidine ring optionally further having substituent(s), and B is a monocyclic aromatic heterocyclic group optionally having substituent(s) (substituents of monocyclic aromatic heterocycle may be bonded to each other to form a ring), or a salt thereof has a superior tachykinin receptor antagonistic action and the like, and is useful as an agent for the prophylaxis or treatment of lower urinary tract disease and the like.
  [FR] L'invention concerne un nouveau dérivé de pipéridine représenté par la formule (I) (I) dans laquelle Ar est un groupe phényle ayant le cas échéant un ou plusieurs substituants, R₁ est un atome d'hydrogène, un groupe hydrocarbure ayant le cas échéant un ou plusieurs substituants, un groupe acyle ou un groupe hétérocyclique ayant le cas échéant un ou plusieurs substituants, Z est un groupe méthylène ayant le cas échéant un ou plusieurs groupes alkyles en C₁ à C₆, le noyau A est un noyau pipéridine ayant le cas échéant un ou plusieurs autres substituants, et B est un groupe hétérocyclique aromatique monocyclique ayant le cas échéant un ou plusieurs substituants (les substituants de l'hétérocycle aromatique monocyclique peuvent être liés les uns aux autres pour former un noyau cyclique), ou un de ses sels, ayant une action d'antagoniste des récepteurs des tachykinines supérieure et autres, et étant utile comme agent de prévention ou de traitement d'une maladie du système urinaire inférieur et similaire.