4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione | 55172-52-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
• CAS: 55172-52-6
• 化学式: C47H78N4O16S
• 分子量: 987.2
• InChiKey: WKIHVYGNGMGRQZ-YZPBMOCRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.15
• 重原子数：
  68
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  301
• 氢给体数：
  7
• 氢受体数：
  20

文献信息

• Pharmaceutical combinations comprising a fungicide, a bacteriostatic sulphonamide and an antibacterial compound for topical application
  申请人：Lukacs Karoly

  公开号：US20050043222A1

  公开（公告）日：2005-02-24

  Medical combination and its method of topical use comprising active ingredients which are sparingly soluble in water, preferably in one single composition against microbes which are pathogenic in humans and animals and which usually appear together. It comprises at least one active ingredient which is effective against several of the opportunally pathogenic strains of the group consisting of fungi Candida, Aspergillus , and/or Fusarium , and aerobic bacteria: Gram-negative bacilli such as Proteus, Pseudomonas, enterobacter species, Escherichia coli, Klebsiella, Serratia marcescens, Citrobacter, Aeromonas ; Gram-negative cocci such as Neisseria, Acinetobacter species; Gram-positive bacilli such as Corynebacterium speies, Bacillus sphaericus , Gram-positive cocci such as Streptococcus species; anaerobic bacteria: Gram-negative cocci such as Bacteroides, Fusobacteria ; Gram-positive cocci such as Peptococcus, Peptostreptococcus species; Gram-positive bacilli such as Clostridium, Propionibacterium, Eubacterium species and Mycobacterium species suh as Mycobacterium ulcerans , microbes similar to bacteria of the Chlamydia species such as Chlamydia trachomatis . To be used for treatment of the skin or mucous membranes bearing epithelial lesions, deficiency or injuries and to be used in body cavities to prevent or cure infections and deficiencies. The composition contains-dispersed in a carrier which is pharmaceutically acceptable on the site of treatment-at least one fungicide, which is preferably azole or polyene type and at least one antibacterial compound preferably of the erythromycin, azalide, linkozamide, polypeptide type and at least one bacteriostatic sulphonamide. Additionals mainly for use on skin may include zinc oxide and asulene. Useful in forms of ointment, tablet, effervescent tablet, suppository, foam.

  医用复方制剂及其局部使用方法，其有效成分易溶于水，最好为单一成分，可防治通常同时出现在人和动物体内的致病微生物。它包含至少一种活性成分，这种活性成分对真菌类中的几种机会致病菌株有效，包括 念珠菌、曲霉 和/或 镰刀菌 和需氧细菌：革兰氏阴性杆菌，如 变形杆菌、假单胞菌、肠杆菌 菌种、 大肠杆菌、克雷伯氏菌、肉豆蔻沙雷氏菌、柠檬酸杆菌、气单胞菌 革兰氏阴性球菌，如 奈瑟氏菌、醋酸杆菌 革兰氏阳性杆菌，如 革兰氏阳性杆菌，如 芽孢杆菌 芽孢杆菌 革兰氏阳性球菌，如 链球菌 厌氧菌：革兰氏阴性球菌，如 厌氧细菌：革兰氏阴性球菌，如乳酸杆菌、镰刀菌 革兰氏阳性球菌，如 革兰氏阳性球菌，如肽球菌、肽链球菌 革兰氏阳性杆菌，如 梭状芽孢杆菌、丙酸杆菌、优杆菌等革兰氏阳性杆菌 种和 分枝杆菌 种，如 溃疡分枝杆菌 等微生物类似于 衣原体 类细菌相似的微生物，如 沙眼衣原体 .用于治疗皮肤或粘膜上皮病变、缺损或损伤，也可用于体腔内预防或治疗感染和缺损。该组合物包含--分散在治疗部位药学上可接受的载体中--至少一种杀真菌剂，最好是唑类或多烯类；至少一种抗菌化合物，最好是红霉素类、氮芥类、链脲类、多肽类；至少一种抑菌磺酰胺。主要用于皮肤的添加剂可包括氧化锌和asulene。可用软膏、片剂、泡腾片、栓剂、泡沫剂等形式。
• US7811599B2
  申请人：——

  公开号：US7811599B2

  公开（公告）日：2010-10-12