glucosamine hydrogen malate | 544455-29-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: glucosamine hydrogen malate
• 英文别名: (2R,3R,4S,5R)-2-amino-3,4,5,6-tetrahydroxyhexanal;2-hydroxybutanedioic acid
• CAS: 544455-29-0
• 化学式: C₄H₆O₅*C₆H₁₃NO₅
• 分子量: 313.262
• InChiKey: WLQJDYKLCGCCBP-BTVCFUMJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.51
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  219
• 氢给体数：
  8
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  苹果酸 、 氨基葡萄糖 以 水 为溶剂， 反应 1.0h， 生成 glucosamine hydrogen malate
  参考文献：
  名称：

  [EN] USE OF ORGANIC GLUCOSAMINE SALTS
  [FR] UTILISATION DE SELS ORGANIQUES DE GLUCOSAMINE

  摘要：

  本发明涉及使用从氨基葡萄糖葡萄糖醛酸盐、氨基葡萄糖抗坏血酸盐、氨基葡萄糖苹果酸盐、氨基葡萄糖氢苹果酸盐、氨基葡萄糖柠檬酸盐、氨基葡萄糖氢柠檬酸盐和氨基葡萄糖二氢柠檬酸盐中选择的有机氨基葡萄糖盐，用于制备治疗关节炎、关节炎相关的炎症和疼痛的药物。本发明还涉及使用上述所述的有机氨基葡萄糖盐制备营养补充剂，作为软骨保护剂，滋养软骨，保护关节，预防组成关节的组织中的水分缺乏，改善关节的功能能力，弹性和灵活性，并预防和逆转运动员的过度运动综合症及其相关影响。

  公开号：

  WO2006012951A1

文献信息

• Ion-pair delivery system for cosmetic and pharmaceutical compositions
  申请人：——

  公开号：US20040228884A1

  公开（公告）日：2004-11-18

  This invention relates to a novel ion-pair delivery system useful for cosmetic, pharmaceutical, and topical nutraceutical applications in which the functional performance and consumer aesthetics of an electron donor composition and an electron acceptor composition, or a proton donor composition and a proton acceptor composition, are synergistically enhanced when such compositions are combined in an ion-pair mode. During ion-pair bonding process, the electron donor composition or the proton acceptor composition become positively charged and the electron acceptor composition or proton donor composition become negatively charged and thus bind together in an ionic manner. Such ion-pair compositions release their electronically bound components in their original state when such compositions are absorbed into skin and reach physiological pH conditions.

  本发明涉及一种新型离子对传递系统，可用于化妆品、药品和局部营养品应用中，其中当电子给体组成物和电子受体组成物，或质子给体组成物和质子受体组成物以离子对模式结合时，其功能性能和消费者美学效果得到协同增强。在离子对键合过程中，电子给体组成物或质子受体组成物变为带正电荷，而电子受体组成物或质子给体组成物则变为带负电荷，从而以离子方式结合在一起。这样的离子对组成物在吸收到皮肤并达到生理pH条件时，释放其电子结合的成分。
• Use of Organic Glucosamine Salts
  申请人：Escaish Ferrer Jose

  公开号：US20070244070A1

  公开（公告）日：2007-10-18

  The present invention relates to the use of an organic glucosamine salt selected from glucosamine glucuronate, glucosamine ascorbate, glucosamine malate, glucosamine hydrogen malate, glucosamine citrate, glucosamine hydrogen citrate, and glucosamine dihydrogen citrate for the preparation of a medicament for the treatment of arthrosis and inflammation and pain associated with arthrosis. The present invention also relates to the use of an organic glucosamine salt, selected from the ones mentioned above, for the preparation of a nutritional supplement acting as a chondroprotector, to nourish the cartilage, protect the joints, prevent water deficit in the tissues that form the joint, improve the joints' functional capacity, elasticity, and flexibility, and prevent and revert the physical overexertion syndrome in athletes, and the effects associated therewith.

  本发明涉及使用从葡萄糖胺葡萄糖醛酸盐、葡萄糖胺抗坏血酸盐、葡萄糖胺苹果酸盐、葡萄糖胺氢苹果酸盐、葡萄糖胺柠檬酸盐、葡萄糖胺氢柠檬酸盐和葡萄糖胺二氢柠檬酸盐中选择的有机葡萄糖胺盐，用于制备治疗关节炎、与关节炎相关的炎症和疼痛的药物。本发明还涉及使用从上述盐中选择的有机葡萄糖胺盐，用于制备营养补充剂，作为软骨保护剂，滋养软骨，保护关节，防止形成关节组织的水分不足，改善关节的功能能力、弹性和灵活性，并预防和逆转运动员的身体过度疲劳综合征及其相关影响。
• Neutrophil function inhibitors which contain glucosamine
  申请人：Dainichiseika Color & Chemicals Mfg. Co., Ltd.

  公开号：EP1238669A2

  公开（公告）日：2002-09-11

  Glucosamine salts are effective for the inhibition of neutrophil functions, and hence, are useful for the prevention and/or treatment of diseases, caused as a result of an excessive extracellular release of active oxygen and antibiotic proteins by neutrophils, such as respiratory disease syndrome and adult respiratory disease syndrome. Use of glucosamine salts can, therefore, provide neutrophil function inhibitors, preventives and/or remedies for diseases caused as a result of an excessive extracellular release of active oxygen and antibiotic proteins by neutrophils, and also methods for the prevention and/or treatment of such diseases.

  葡萄糖胺盐可有效抑制中性粒细胞功能，因此可用于预防和/或治疗因中性粒细胞在细胞外过度释放活性氧和抗生素蛋白而引起的疾病，如呼吸系统疾病综合征和成人呼吸系统疾病综合征。因此，使用葡萄糖胺盐可以提供中性粒细胞功能抑制剂，预防和/或治疗由于中性粒细胞在细胞外过度释放活性氧和抗生素蛋白而引起的疾病，以及预防和/或治疗此类疾病的方法。
• Neutrophil function inhibitors
  申请人：Koyo Chemical Co., Ltd.

  公开号：US20020128230A1

  公开（公告）日：2002-09-12

  Glucosamine salts are effective for the inhibition of neutrophil functions, and hence, are useful for the prevention and/or treatment of diseases, caused as a result of an excessive extracellular release of active oxygen and antibiotic proteins by neutrophils, such as respiratory disease syndrome and adult respiratory disease syndrome. Use of glucosamine salts can, therefore, provide neutrophil function inhibitors, preventives and/or remedies for diseases caused as a result of an excessive extracellular release of active oxygen and antibiotic proteins by neutrophils, and also methods for the prevention and/or treatment of such diseases.

  葡萄糖胺盐可有效抑制中性粒细胞功能，因此可用于预防和/或治疗因中性粒细胞在细胞外过度释放活性氧和抗生素蛋白而引起的疾病，如呼吸系统疾病综合征和成人呼吸系统疾病综合征。因此，使用葡萄糖胺盐可以提供中性粒细胞功能抑制剂，预防和/或治疗由于中性粒细胞在细胞外过度释放活性氧和抗生素蛋白而引起的疾病，以及预防和/或治疗此类疾病的方法。
• Hydroxy acids based delivery systems for skin resurfacing and anti-aging compositions
  申请人：——

  公开号：US20040092482A1

  公开（公告）日：2004-05-13

  This invention relates to in-situ preparation of the derivatives of various hydroxy acids (HA), such as &agr;-(Alpha) Hydroxy Acids (AHA), &bgr;-(Beta) Hydroxy Acids (BHA), and Poly-Hydroxy Acids (PHA) with certain skin beneficial organic hetero-atom bases and their application in skin resurfacing (exfoliation), and in the synergistic treatment and regulation of topical disorders of skin such as skin aging, wrinkles, acne, rosacea, age-spots, canker sores, striae distensae (stretch marks), pimples, skin redness, and dry skin conditions of cracking, flaking, and scaling. Most HA derivatives produced by the in-situ method do not cause skin irritation and skin redness effects that are commonly experienced with AHA and BHA, yet there is no loss of their skin beneficial effects. These compositions can be traditional water and oil emulsions, liposomes, suspensions, colloids, solutions, masks, muds, serums, sprays, gels, lotions, creams, cleansers, and anhydrous systems, thus offering a wide choice of formulations to meet their consumer appeal and acceptance requirements.

  本发明涉及原位制备各种羟基酸（HA）的衍生物，如&agr;-（α）羟基酸（AHA）、&bgr；-(β)羟基酸 (BHA)、聚羟基酸 (PHA) 与某些对皮肤有益的有机杂原子基团的衍生物，并将其应用于焕肤（去角质）、协同治疗和调节皮肤局部疾病，如皮肤老化、皱纹、痤疮、红斑痤疮、老年斑、口腔溃疡、妊娠纹、丘疹、皮肤发红以及干性皮肤皲裂、脱皮和脱屑等。通过原位法生产的大多数 HA 衍生物不会造成 AHA 和 BHA 常见的皮肤刺激和皮肤发红现象，同时也不会失去对皮肤有益的功效。这些组合物可以是传统的水和油乳剂、脂质体、悬浮液、胶体、溶液、面膜、泥浆、精华液、喷雾剂、凝胶、乳液、膏霜、清洁剂和无水体系，因此可提供多种配方选择，以满足消费者的吸引力和接受度要求。