2-(2-imino-thiazol-3-yl)-1-(3-nitro-phenyl)-ethanone | 802834-15-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-imino-thiazol-3-yl)-1-(3-nitro-phenyl)-ethanone
• 英文别名: 2-(2-iminothiazol-3(2H)-yl)-1-(3-nitrophenyl)ethanone；2-(2-Imino-1,3-thiazol-3-yl)-1-(3-nitrophenyl)ethanone
• CAS: 802834-15-7
• 化学式: C₁₁H₉N₃O₃S
• 分子量: 263.277
• InChiKey: DHFVWJLZKXODRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(2-imino-thiazol-3-yl)-1-(3-nitro-phenyl)-ethanone 在 sodium tetrahydroborate 作用下， 以 异丙醇 为溶剂， 反应 1.0h， 生成 2-(2-imino-thiazol-3-yl)-1-(3-nitro-phenyl)-ethanol
  参考文献：
  名称：

  新型广谱驱虫药。4-咪唑并咪唑[2,1-b]噻唑的四咪唑及其相关衍生物。

  摘要：

  DOI：

  10.1021/jm00322a023
• 作为产物：
  描述：

  2-氨基噻唑 、 2-溴-3'-硝基苯乙酮 以 异丙醇 为溶剂， 反应 1.5h， 生成 2-(2-imino-thiazol-3-yl)-1-(3-nitro-phenyl)-ethanone
  参考文献：
  名称：

  新型广谱驱虫药。4-咪唑并咪唑[2,1-b]噻唑的四咪唑及其相关衍生物。

  摘要：

  DOI：

  10.1021/jm00322a023

文献信息

• HETEROCYCLIC COMPOUNDS AS SWEETENER ENHANCERS
  申请人：Redpoint Bio Corporation

  公开号：EP2061321A2

  公开（公告）日：2009-05-27
• Heterocyclic Compounds as Sweetener Enhancers
  申请人：ATWAL Karnail S.

  公开号：US20100197813A1

  公开（公告）日：2010-08-05

  The present invention is directed to the use of a compound of Formula I and physiologically acceptable salts thereof wherein G 1 , G 2 , G 3 , R 1 , R 2 , R 7 , R 3 , R 4 , and R 5 are defined herein. Compounds according to Formula I can be used to enhance a sweet taste produced by a tastant. The invention is also directed to compositions comprising a compound according to the above formula. Other aspects of the invention provide methods, compounds, and compositions for improved food products wherein the food product comprises a compound according to Formula I and a reduced amount of a sweet tastant.
• US7674831B2
  申请人：——

  公开号：US7674831B2

  公开（公告）日：2010-03-09
• [EN] HETEROCYCLIC COMPOUNDS AS SWEETENER ENHANCERS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES EN TANT QU'AMPLIFICATEURS D'ÉDULCORANTS
  申请人：REDPOINT BIO CORP

  公开号：WO2008024364A2

  公开（公告）日：2008-02-28

  [EN] The present invention is directed to the use of a compound of Formula, ( I ) and physiologically acceptable salts thereof wherein G^1, G^2, G^3, R¹, R², R⁷, R³, R⁴, and R⁵ are defined herein. Compounds according to Formula I can be used to enhance a sweet taste produced by a tastant. The invention is also directed to compositions comprising a compound according to the above formula. Other aspects of the invention provide methods, compounds, and compositions for improved food products wherein the food product comprises a compound according to Formula, ( I ) and a reduced amount of a sweet tastant.
  [FR] La présente invention concerne l'utilisation d'un composé de formule (I) et de ses sels physiologiquement acceptables, G¹
• Novel Broad-Spectrum Anthelmintics. Tetramisole¹ and Related Derivatives of 6-Arylimidazo[2,1-b]thiazole
  作者：Alfons H. M. Raeymaekers、Fernand T. N. Allewijn、Jan Vandenberk、Paul J. A. Demoen、Theo T. T. Van Offenwert、Paul A. J. Janssen

  DOI：10.1021/jm00322a023

  日期：1966.7