N-butyl-stearoyl amide | 4219-50-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-butyl-stearoyl amide
• 英文别名: octadecanamide, N-butyl-；N-butylstearamide；N-butyl-stearamide；N-Butyl-stearamid；Stearinsaeure-butylamid；N-Butyl-stearinamid；n-Butyloctadecanamide
• CAS: 4219-50-5
• 化学式: C₂₂H₄₅NO
• 分子量: 339.605
• InChiKey: OHOPIZUOANPWQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  24
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  N-butyl-stearoyl amide 生成 4,5-二氢-2-十七烷基-1H-咪唑
  参考文献：
  名称：

  BUTLER, R. N.;THORNTON, J. D.;OREGAN, C. B., J. CHEM. SOC. PERKIN TRANS., 1983, N 9, 2197-2200

  摘要：

  DOI：
• 作为产物：
  描述：

  硬脂酸 在 六甲基二硅氧烷 、 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 作用下， 以 乙酸乙酯 为溶剂， 反应 48.0h， 生成 N-butyl-stearoyl amide
  参考文献：
  名称：

  HMDO-Promoted Peptide and Protein Synthesis in Ionic Liquids

  摘要：

  Hexamethyldisiloxane (HMDO) has been developed to efficiently promote the metal-free direct coupling of an amino function of one cysteine-free peptide or protein and a C-terminal thioester of the second peptide in ionic liquids. The amide-coupling reaction proceeds smoothly under mild conditions to afford the corresponding products in good to excellent yields (63-94%). Peptide couplings were also achieved using in-situ-generated thioesters by the thioesterification of oxo esters.

  DOI：

  10.1021/jo400797t

文献信息

• [EN] IMIDAZO [4, 5 - B] PYRIDINE DERIVATIVES AS ALK AND JAK MODULATORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS<br/>[FR] DÉRIVÉS IMIDAZO [4,5-B] PYRIDINE COMME MODULATEURS D'ALK ET DE JAK POUR LE TRAITEMENT DE TROUBLES PROLIFÉRATIFS
  申请人：CEPHALON INC

  公开号：WO2013116291A1

  公开（公告）日：2013-08-08

  This application relates to compounds of the Formula I as defined herein, and/or salts thereof. This application further relates to compositions and methods of using these compounds and/or salts thereof. The compounds of Formula I are useful as ALK and JAK modulators for the treatment of proliferative disorders.

  这项申请涉及到本文所定义的Formula I化合物及/或其盐。此申请进一步涉及到使用这些化合物和/或其盐的组合物和方法。Formula I化合物可用作ALK和JAK调节剂，用于治疗增殖性疾病。
• Thermochromic microencapsulated pigments
  申请人：THE PILOT INK CO., LTD.

  公开号：EP1084860A2

  公开（公告）日：2001-03-21

  Disclosed is a thermochromic microencapsulated pigment which comprises as four essential components (a) an electron-donating chromatic organic compound, (b) an electron-accepting compound, (c) a reaction medium determining the temperatures at which the color reactions of component (a) with component (b) take place, and (d) a color change temperature regulator, the color change temperature regulator (d) comprising one or more compounds selected from the group consisting of esters, alcohols, ketones, acid amides, hydrocarbons, and fatty acids and having a melting point Y (°C) satisfying the relationship (X+30)°C≤Y≤200°C, wherein X (°C) is the melting point of component (c), and the four essential components being microencapsulated.

  本发明公开了一种热致变色微胶囊颜料，它由四种基本成分组成：(a) 一种电子供色有机化合物；(b) 一种电子受色化合物；(c) 一种决定成分(a)与成分(b)发生颜色反应的温度的反应介质；(d) 一种变色温度调节剂、变色温度调节剂(d)包括一种或多种从酯、醇、酮、酸酰胺、烃和脂肪酸组成的组中选出的化合物，其熔点 Y(℃)满足(X+30)℃≤Y≤200℃的关系，其中 X(℃)是组分(c)的熔点，四种基本组分被微胶囊化。
• Composition comprising a sulfur-containing, phosphorus-containing compound, and/or its salt, and uses thereof
  申请人：Afton Chemical Corporation

  公开号：EP1785470A2

  公开（公告）日：2007-05-16

  There is disclosed herein an additive composition including a compound of formula (III): wherein R1, R2, R3, R4, R5, R6, R7, R8, and R9 are independently selected from the group consisting of hydrogen, cyano, and hydrocarbyl groups comprising from about 1 to about 30 carbon atoms.

  本文公开了一种添加剂组合物，其中包括式（III）化合物： 其中 R1、R2、R3、R4、R5、R6、R7、R8 和 R9 独立地选自氢、氰基和包含约 1 至约 30 个碳原子的烃基组成的组。
• Lubricant composition
  申请人：Afton Chemical Corporation

  公开号：EP1785474A1

  公开（公告）日：2007-05-16

  There is disclosed a composition including a boron-containing compound, and at least one of a sulfur-containing, phosphorus-containing compound and its salt. Methods of making and using the composition are also disclosed.

  本发明公开了一种组合物，包括一种含硼化合物和至少一种含硫、含磷化合物及其盐。还公开了制造和使用该组合物的方法。
• A gear additive composition
  申请人：Afton Chemical Corporation

  公开号：EP1785475A1

  公开（公告）日：2007-05-16

  There is disclosed herein a gear additive composition including a nitrogen-containing compound and a phosphorus-containing compound, wherein the ratio of total base number to total acid number of the gear additive composition is greater than about 0.94. There is also disclosed a gear lubricant composition having the disclosed gear additive and a reaction product of a sulfur-containing compound, a phosphorous-containing compound, and a nitrogen-containing compound. Methods of using both compositions are also disclosed.

  本文公开了一种齿轮添加剂组合物，包括一种含氮化合物和一种含磷化合物，其中齿轮添加剂组合物的总碱数与总酸数之比大于约 0.94。还公开了一种齿轮润滑剂组合物，该组合物具有所公开的齿轮添加剂以及含硫化合物、含磷化合物和含氮化合物的反应产物。还公开了使用这两种组合物的方法。