(R)-2-butyl-piperidine | 132883-85-3

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: (R)-2-butyl-piperidine
• 英文别名: (R)-2-Butyl-piperidin；(2R)-2-butylpiperidine
• CAS: 132883-85-3
• 化学式: C₉H₁₉N
• 分子量: 141.257
• InChiKey: PCNXNSPEWIRGJO-SECBINFHSA-N

物化性质

• 沸点：
  193.3±8.0 °C(Predicted)
• 密度：
  0.816±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (3S)-5-(benzotriazol-1-yl)-3-phenyl-3,5,6,7,8,8a-hexahydro-2H-[1,3]oxazolo[3,2-a]pyridine 在 palladium on activated charcoal 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， -95.0~25.0 ℃ 、137.9 kPa 条件下， 反应 36.0h， 生成 (R)-2-butyl-piperidine
  参考文献：
  名称：

  Efficient Routes to Chiral 2-Substituted and 2,6-Disubstituted Piperidines

  摘要：

  The syntheses of chiral 2-substituted and 2,6-disubstituted piperidines, and piperidin-2-ylphosphonates, via benzotriazole methodology are described.

  DOI：

  10.1021/jo980719d

文献信息

• Loeffler; Ploecker, Chemische Berichte, 1907, vol. 40, p. 1312
  作者：Loeffler、Ploecker

  DOI：——

  日期：——
• [EN] ANTIINFECTIVE COMPOUNDS<br/>[FR] COMPOSÉS ANTI-INFECTIEUX
  申请人：SUMMIT CORP PLC

  公开号：WO2010029313A1

  公开（公告）日：2010-03-18

  Described are various compounds and methods for the treatment of infections. In particular, alkaloids and imino sugars with antiviral activity are described, including those with activity against HCV and RSV.
• [EN] COMPOUNDS FOR THE TREATMENT OF FLAVIVIRAL INFECTIONS<br/>[FR] COMPOSÉS POUR LE TRAITEMENT D'INFECTIONS FLAVIVIRALES
  申请人：SUMMIT CORP PLC

  公开号：WO2010015815A2

  公开（公告）日：2010-02-11

  Described are various compounds and methods for the treatment of flaviviral infections. In particular, alkaloids and imino sugars in arabinose and/or lyxose stereochemical configuration with antiflaviviral activity are described.
• [EN] TREATMENT OF ENERGY UTILIZATION DISEASES<br/>[FR] TRAITEMENT DE MALADIES UTILISANT DE L'ÉNERGIE
  申请人：SUMMIT CORP PLC

  公开号：WO2010049678A2

  公开（公告）日：2010-05-06

  Described are various compounds, in particular iminosugars, for the treatment of energy utilization diseases, in particular diabetes (including type 1 diabetes, type 2 diabetes and insulin resistance) and metabolic syndrome (including any disease or disorder associated therewith, for example central obesity and elevated levels of triglycerides).
• Efficient Routes to Chiral 2-Substituted and 2,6-Disubstituted Piperidines
  作者：Alan R. Katritzky、Guofang Qiu、Baozhen Yang、Peter J. Steel

  DOI：10.1021/jo980719d

  日期：1998.9.1

  The syntheses of chiral 2-substituted and 2,6-disubstituted piperidines, and piperidin-2-ylphosphonates, via benzotriazole methodology are described.